Aging Treatment Research Articles

Study of fluoroquinolonesresistance in rifampicin-resistant tuberculosis patients in Beijing: Characteristics, trends, and treatment outcomes.

China is a high-burden country for multidrug-resistant tuberculosis/rifampin-resistant tuberculosis (MDR/RR-TB). Fluoroquinolones (FQs) are key drugs for the treatment of patients with MDR/RR-TB. However, research on the resistance of FQs in Beijing is limited. We collected clinical isolates from all patients with pulmonary TB in Beijing from January 2016 to December 2021, conducted drug-sensitivity tests and sequencing for levofloxacin (LFX) and moxifloxacin (MFX), and collected the treatment plans and outcomes of the patients. A total of 8512 clinical isolates were collected from patients with pulmonary TB, and 261 RR-TB strains were screened. The proportions of drug-sensitive and drug-resistant strains significantly differed by age group and treatment history. The rates of LFX and MFX resistance were 27.6% (72/261) and 36.4% (95/261), respectively. The detection rates of MDR-TB and pre-extensively drug-resistant TB (pre-XDR-TB) were 73.2% (191/261) and 36.4% (95/261), respectively, and the trends were significant (χ2 trend = 9.995, p = 0.002; χ2 trend = 12.744, p = 0.026). Among the 261 RR-TB strains, 14.9% (24/261) were sensitive to LFX but resistant to MFX. Among the four patients with LFX-resistant TB who received LFX treatment failed in three patients(Fisher's exact test, p = 0.009). The common mutation sites were 94and 90 in gyrA. A novel mutation Ala90Ser was discovered. FQs resistance trends in RR-TB patients in Beijing are striking. Strains showed incomplete cross-resistance to LFX and MFX. Testing for FQs resistance and developing a reasonable treatment plan are recommended. Attention should be given to the changing trends in MDR-TB and pre-XDR-TB.

Can the aging process necessarily weaken the effect of biochar on cadmium-contaminated soil remediation: considering biochar at different pyrolysis temperatures and aging treatment.

Biochar has widely used to immobilize soil heavy metals in recent years, while the properties of biochar varied with environmental conditions. The influence of biochar aging on fixation and speciation transformation of Cd in soil remains unclear. This study explores how biochar aging affects the fixation and speciation transformation of Cd in soil. Rice straw biochar (RBC) prepared at different pyrolysis temperatures (300°C, 500°C, and 700°C) was aged under three treatments (drying and watering cycle (DW), H2O2 oxidation (HO), and citric acid acidification (CA)) to investigate the effects of the aging process on the adsorption and passivation capacity for Cd. Results showed that the aging treatment increased Cd adsorption on RBC300 by 73.69% to 216.15%, while adsorption on RBC500 and RBC700 decreased by 11.52% to 74.56% and 7.40% to 75.89%, respectively. The addition of both fresh and aged RBC raised pH, DOC, and TOC in Cd-contaminated soil, aiding in Cd fixation. Either fresh or aged RBC addition enhance the stability of Cd in soil. Compared to CK treatment, residual Cd content rose by 28.63% to 43.71%, while both acid-extractable and reducible Cd contents decreased by 9.144% to 10.95%. Furthermore, the available Cd content in the soil saw a reduction of 10.45% to 30.77%, and high-temperature pyrolytic RBC exhibited a stronger capacity for Cd passivation in the soil. Both fresh and aged RBC indirectly reduced Cd bioavailability by affecting soil pH, DOC, and TOC, and the nature aging process (DW) did not weaken the effect of biochar on Cd-contaminated soil remediation. Thus, biochar has a long-term potential for mitigating Cd pollution in farmland.

The Role of Stratified Cumulative Antibiograms in the (Choice of Appropriate Antibiotics in Urinary Tract Infection) Management of Urinary Tract Infections

Urinary tract infections (UTIs) are one of the most common bacterial diseases both in communities and in hospitalized patients, and at the same, time they are one of the most common indications for the use of antibiotics. UTI guidelines are generally available nationally or internationally, but they do not address all aspects of UTI treatment for different patient cohorts, age, gender, or comorbidities. The aim of the study was to point out the importance of stratified cumulative antibiograms at the level of individual health care facilities and the significant differences between epidemiological data, not only at the national level, but also at the local level. Our study analyses data from 383 patients with UTIs from a hospital department, General University Hospital (GUH), and 272 patients from an outpatient medical facility, Urocentrum (UC). This analysis focuses on the most common UTI causative agent, Escherichia coli, its representation as the causative agent of UTI in patients with complicated acute cystitis (N30), and its representation in complicated acute cystitis in patients with prostate cancer (C61). In addition to the frequency of occurrence, a sub-analysis of the incidence of resistance of E. coli to commonly used antibiotics by age, gender, diagnosis, and medical facility was performed. Results: The most common causative agent of UTI was E. coli. In patients with N30, it was 70% in GUH and 54% in UC, but in oncological patients with UTI, it was only 39% and 35%, respectively. In patients with UTI in C61, there was a significant difference in susceptibility of E. coli between individual health care facilities. Lower resistance was found in UC opposite to GUH isolates in ampicillin, with 29.8% vs. 65%, p = 0.001; amoxicillin/clavulanic acid, with 8.5% vs. 30%, p = 0.01; with 2.1% vs. 17.5% in pivmecillinam, p = 0.01; with 10.6% vs. 37.5% in co-trimoxazole, p = 0.003; and ciprofloxacin, with 10.6% vs. 30%, p = 0.04. The study shows significant differences in the sensitivity of urinary E. coli isolates in patients in relation to age, gender, medical devices, and the presence of comorbidities.

Biochemical Hypogonadism in Aging Testicular Cancer Survivors: A Clinical Challenge.

Few longitudinal studies have described the prevalence and development of biochemical hypogonadism in aging testicular cancer survivors (TCSs) in comparison to men from the general population (control subjects). Serum total and free testosterone (Ttotal, Tfree) were measured in 593 TCSs median11 and 27 years after TC diagnosis (Survey-First; Survey-Last). Post-treatment adverse health outcomes (AHOs) were recorded. The results were compared to those in 578 control subjects. Treatment was stratified as surgery alone, radiotherapy alone, or platinum-based chemotherapy. Biochemical hypogonadism was defined as Ttotal <8nmol/l, or as Ttotal <12nmol/l and Tfree <225pmol/l. We used multivariable logistic regression analysis to explore associations with age and treatment intensity. Statistical significance was set at p<0.05. Between the first and last survey the prevalence of biochemical hypogonadism increased from 12% to 41% in the TSC group and from 5% to 11% in the control group. Three decades after diagnosis, the probability of biochemical hypogonadism was significantly correlated with increasing age and greater treatment intensity. The combined age- and treatment- related probability of hypogonadism was more than threefold higher in the TCS group than in the control group. At the last survey, fewer eugonadal than hypogonadal TCS men reported at least one AHO attributable to androgen deficiency (54% vs 72%; p<0.001). Limitations include the availability of only one blood sample per survey wave. For aging TCSs, the probability of biochemical hypogonadism depends on age and prior treatment intensity and is threefold higher than for control subjects at 30yr after diagnosis. As late hypogonadism is associated with AHO incidence, the development of hypogonadism should be monitored via regular blood tests during TCS follow-up. Depending on the treatment they received, older survivors of testicular cancer (TC) are at persistent risk of lower testosterone levels. Our study revealed low testosterone in 40% of TC survivors older than 60 years compared to 10% of similarly aged men from the general population. Low testosterone is associated with chronic conditions such as diabetes, fatigue, and/or erectile dysfunction. Testosterone should be regularly monitored during follow-up for TC survivors.

A high strength and plasticity Al-Li-Cu alloy with high Li content prepared via large reduction rolling and aging treatment

A high strength and plasticity Al-Li-Cu alloy with high Li content prepared via large reduction rolling and aging treatment

The influences of aging treatment on the serrated flow of a superalloy specially designed for additive manufacturing

The influences of aging treatment on the serrated flow of a superalloy specially designed for additive manufacturing

Tailoring yield strength in Fe-20Mn-9Al-1.5C-3Cr-2Ni austenitic lightweight steels achieved by larger volume and size κ′-Carbide under extended aging

We investigate the microstructural evolution and its effects on mechanical properties of Fe-20Mn-9Al-1.5C-3Cr-2Ni austenitic lightweight steel, with particular emphasis on the intragranular κ’-carbides that are coherent with the austenitic matrix. By varying the aging treatment, we obtained different sizes and volume fractions of these coherent κ′-carbides. Our results reveal that the larger volumes and sizes κ′-carbides significantly contribute to the ultra-high yield strength (YS) of 1269 MPa while maintaining good total elongation (TEL) of 25.0 %. The YS arises from a combination of precipitation strengthening, solid solution strengthening, and grain boundary strengthening. Notably, precipitation strengthening was pivotal, contributing to an increase in strength of 501 MPa as the aging time was extended to 2040 min.

Enhancing the precipitation hardening ability of Al-Mg-Ga-In-Sn alloy through low-temperature aging treatment

Enhancing the precipitation hardening ability of Al-Mg-Ga-In-Sn alloy through low-temperature aging treatment

Use of endolaser associated with fractional CO2 laser for facial rejuvenation: Clinical experience in Brazil

Background: The Endolaser used in aesthetic procedures in Brazil is characterized by the use of equipment that emits wavelengths of 1470 nm and 980 nm. Its main therapeutic action is to generate intense heat in the subcutaneous tissues to damage adipose tissue and heat the skin to stimulate collagen production. The CO2 laser is recommended for different dermatological and aesthetic conditions and is a great resource for skin rejuvenation. The association of these two resources is viable due to their therapeutic actions on the skin. Objective: Considering that the Endolaser is already associated with several therapeutic resources, including fractional lasers, this study aimed to describe the clinical experience of the authors in Brazil regarding its use associated with the fractional CO2 laser for the treatment of facial aging. Material and Methods: This study is characterized by exploratory research presented through a narrative review, to describe the action of the Endolaser associated with the fractional CO2 laser in the treatment of facial aging. In addition to the literature review, some clinical findings obtained through a retrospective analysis of medical records were added to describe the authors' clinical experience in Brazil of using Endolaser associated with fractional CO2 laser in the treatment of facial aging. Results: The association of the Endolaser with the fractional CO2 laser proved to be effective and safe under the conditions described in this work. The Endolaser is the first resource to be applied, followed immediately by the fractional CO2 laser. After using the lasers, drug delivery is carried out with a cosmeceutical solution, and in order to accelerate the product’s drying on the skin, we cooled the skin with a jet of cold air. Then, with the skin dry, we sealed the treated region by applying 10% retinoic acid. The treatment is completed at home with the application of dexamethasone acetate, moisturizing cream and sunscreen. Conclusion: The combined treatment of Endolaser and fractional CO2 Laser proved to be efficient and safe, as long as the parameters and protocols suggested in this study are followed. Mainly respecting dermal tolerance to skin heating in order to enhance the results, as with this laser equipment we can optimize performance in different layers, as we understood that they are complementary therapies.

Aging, cancer, and autophagy: connections and therapeutic perspectives

Aging and cancer are intricately linked through shared molecular processes that influence both the onset of malignancy and the progression of age-related decline. As organisms age, cellular stress, genomic instability, and an accumulation of senescent cells create a pro-inflammatory environment conducive to cancer development. Autophagy, a cellular process responsible for degrading and recycling damaged components, plays a pivotal role in this relationship. While autophagy acts as a tumor-suppressive mechanism by preventing the accumulation of damaged organelles and proteins, cancer cells often exploit it to survive under conditions of metabolic stress and treatment resistance. The interplay between aging, cancer, and autophagy reveals key insights into tumorigenesis, cellular senescence, and proteostasis dysfunction. This review explores the molecular connections between these processes, emphasizing the potential for autophagy-targeted therapies as strategies that could be further explored in both aging and cancer treatment. Understanding the dual roles of autophagy in suppressing and promoting cancer offers promising avenues for therapeutic interventions aimed at improving outcomes for elderly cancer patients while addressing age-related deterioration.

Microstructures and Mechanical Properties of SUS 630 Stainless Steel: Effects of Age Hardening in a Tin Bath and Atmospheric Environments

This study investigates the solution-aging treatment of precipitation-hardening SUS 630 stainless steel, alongside an analysis of the carbon emissions generated by the energy consumed during aging treatments. By employing atmospheric and liquid tin as aging media, the research comprehensively explores the effects of aging treatments on the characteristics of 630 stainless steel. The maximum hardness value for the 630 stainless steel was observed after atmospheric aging at 500 °C for 1 h. The given 630 stainless steel obtained its maximum hardness value after atmospheric aging at 500 °C for 1 h, indicating that the formation of secondary precipitates strengthens the steel’s performance. By leveraging the intrinsic characteristics of liquid tin, using it as an aging medium (Sn bath aging) significantly improves the efficiency of the aging process, achieving mechanical properties comparable to those of atmosphere-aged steel. The 630 stainless steel aged in a Sn bath exhibited a refined martensitic matrix with substantial precipitate formation, contributing to superior impact toughness and dynamic fatigue resistance. With an equivalent mass and performance, Sn bath aging notably reduced the duration of the treatment compared to atmospheric aging, leading to substantial energy savings and reduced carbon emissions. The Sn bath treatment, recognized in metallurgical science and heat treatment for its excellent thermal conductivity and recyclability, shows potential to enhance process efficiency and enable low carbon emissions in the heat treatment industry. By highlighting the differences between aging methods, this study provides solutions for optimizing heat treatment processes and thereby achieving industrial advancement and sustainability goals.

A framework of biomarkers for skeletal muscle aging: a consensus statement by the Aging Biomarker Consortium

Abstract The skeletal muscle is an important organ for movement and metabolism in human body, and its physiological aging underlies the occurrence of muscle atrophy and sarcopenia. China has the largest aging population in the world and is facing a grand challenge with how to prevent and treat skeletal muscle aging-related diseases. To address this difficult problem, the Aging Biomarker Consortium (ABC) of China has reached an expert consensus on biomarkers of skeletal muscle aging by synthesizing literatures and insights from scientists and clinicians. This consensus attempts to provide a comprehensive assessment of biomarkers associated with skeletal muscle aging, and proposes a systematic framework to classify them into three dimensions: functional, structural, and humoral. Within each dimension, the experts recommend clinically relevant biomarkers for skeletal muscle aging. This consensus aims to lay the foundation for future research on skeletal muscle aging, facilitating precise prediction, diagnosis, and treatment of skeletal muscle aging and sarcopenia. It is anticipated to make significant contributions to healthy aging of skeletal muscle in the elderly population in China and around the world as well.

Skin cancer risk in over 200.000 patients with haematologic malignancies in 30 years; a nationwide population-based study in the Netherlands.

Patients with haematologic malignancies are at increased risk of developing skin cancer and often experience worse skin cancer-related outcomes. However, there is a lack of nationwide, population-based data with long-term follow-up on the incidence and risks of different skin cancer types across all haematologic malignancies. To assess population-based risk estimates for cutaneous squamous cell carcinoma (CSCC), malignant melanoma (MM), Merkel cell carcinoma (MCC), and basal cell carcinoma (BCC) among patients with haematologic malignancies, stratified by skin cancer type and haematologic malignancy subgroup. These estimates can serve as a base for surveillance guidelines and patient education. This nationwide population-based epidemiologic cohort study used data on 210,794 patients diagnosed with a haematologic malignancy between 1989 and 2020 from the Netherlands Cancer Registry (NCR). In addition, data on each type of histopathologically confirmed skin cancer per patient after haematologic malignancy diagnosis was retrieved from the NCR. Patients with a history of skin cancer prior to their haematologic malignancy were excluded. Cumulative incidences, standardized incidence ratio's (SIRs), and absolute excess risks for each of the four skin cancers were calculated and stratified by haematologic malignancy subgroup, age, sex, follow-up, and primary treatment. The overall 10-year cumulative incidence of developing a first skin cancer was 2.6% for CSCC, 0.5% for MM, 0.05% for MCC, and 4.8% for BCC. Compared to the general population, nearly all haematologic malignancy subgroups showed more than a twofold increased risk of CSCC, MM, MCC and BCC. Patients with chronic lymphocytic leukemia (CLL) showed the highest risks for each of the four skin cancers, with SIRs of 4.4 for CSCC, 2.7 for MM, 9.3 for MCC, and 2.6 for BCC. These elevated risks persisted for more than 30 years after haematologic malignancy diagnosis. Patients with all types of haematologic malignancies, and especially those with CLL, have a lifetime increased risk of developing different types of skin cancer. These findings highlight the importance of creating awareness among patients and care providers about this increased risk and promoting sun-protective measures and regular skin self-examinations in this high-risk population.

P0981 Comparative efficacy of standard vs enhanced dose treatment with infliximab in the management of acute severe ulcerative colitis: a single centre retrospective cohort study

Abstract Background Acute severe ulcerative colitis (ASUC) often requires rescue therapy with infliximab, typically administered at an initial dose of 5mg/kg or 10mg/kg. There is some uncertainty regarding the optimal dose of infliximab for rescue therapy and current guidance leaves this to the discretion of the treating clinician. A previous multicentre randomised controlled trial (PREDICT-UC) did not find a significant difference in clinical response or colectomy rates between 5mg/kg and 10mg/kg of infliximab in steroid-refractory ASUC 1. This study aimed to compare the clinical outcomes of patients receiving either 5mg/kg or 10mg/kg infliximab in the management of ASUC. Methods This retrospective cohort study examined patients with ASUC who were treated with rescue infliximab between 2019 and 2022. Patients were categorised into two groups based on the dose received; 5mg/kg and 10mg/kg. Demographic and clinical variables, including age, sex, disease extent (Montreal classification), and prior treatments (no prior treatment, 5-ASA, biologics), were recorded. The outcomes measured included remission (defined as sustained remission at 1 year), the need for surgery, the requirement for additional doses of infliximab, or change in biological agent. Outcomes at 1 month, 6 months, and 1 year were also recorded. Chi-square tests were used to analyse differences between the two treatment groups. Results Of the 50 UC patients, 60% received 5 mg/kg, and 40% received 10 mg/kg. No significant differences were found between the 5 mg/kg and 10 mg/kg infliximab treatment groups for outcomes including surgery (p = 1.00), remission (p = 0.22), and biologic switch (p = 0.22). Additionally, no significant differences were observed when categorising patients by pre-existing treatment (p = 0.06) or disease severity subgroups (E1, E2, E3). When assessing the effect of severe disease markers on treatment outcomes, no significant difference in colectomy rates was found between the two groups for CRP &amp;gt; 50 mg/L (p = 0.34) and albumin &amp;lt; 25 g/L (p = 0.13). Conclusion This study showed no significant difference in the clinical outcomes between patients receiving 5mg/kg and 10mg/kg infliximab for the management of ASUC. These findings suggest that escalating the dose to 10mg/kg does not provide a clear clinical advantage in reducing the need for surgery or achieving sustained remission. Larger, multicentre studies with more diverse patient populations are needed to further investigate the potential benefits of higher infliximab dosing in this clinical context.

Gingival margin interfacial microleakage, staining, and push-out strengths of gingival colored composite resins in denture bases.

Staining at the gingival margin could impact denture longevity, but the behavior of gingival colored composite resins (GCCs) in this area remains unclear. This in vitro study evaluated surface staining, microleakage, and push-out bond strength at the gingival margin of artificial teeth, comparing two consistencies of GCCs with two resin base materials. Specimens included artificial teeth (Ivostar; Ivoclar AG) and two acrylic resin base materials: conventional (Ondacryl; Clássico) and high-impact (Diamond D; Keystone Industries) (n=300). Specimens were divided in three groups: control (acrylic resin) and experimental groups, receiving one of the two GCCs consistencies: paste (SR Nexco; Ivoclar AG) or flowable (Gradia Plus Gum; GC Europe)). Initial artificial aging treatment in distilled water (5 days at 55º C) was performed and the specimens were then immersed in 5% methylene blue dye or coffee for 7 days at 37ºC. Staining was visually assessed, and the specimens were sectioned for dye infiltration analysis at the gingival margin using a stereomicroscope. Bond strength was measured with the push-out test in the gingival colored composite resin specimens. Data were analyzed using 2-way and 3-way ANOVA with Bonferroni post hoc test and Kruskal-Wallis test with Dunn post hoc test (α=.05). A significantly higher surface staining and microleakage was observed in experimental groups compared to the control (acrylic resin) (P<.001). Surface staining revealed that paste consistency GCC was more susceptible to discoloration in coffee, while flowable GCC was more affected by methylene blue. Lower microleakage values were observed in the control (acrylic resin) groups (0.11 ±0.13mm for the conventional base and 0.08 ±0.11mm for the high-impact base) in comparison with the experimental groups (P<.05). The flowable GCC showed the highest microleakage with methylene blue (0.98 ±0.21 mm for the conventional base and 0.91 ±0.31 mm for the high-impact base), significantly greater than the paste consistency for both base materials (0.53 ±0.22 mm for the conventional base and 0.66 ±0.34 mm for the high-impact base; P<.001). For coffee immersion, both GCC consistencies displayed similar microleakage values (P>.05). Push-out bond strength was comparable between paste and flowable GCCs (P>.05). Microleakage at the gingival margin was significantly greater when GCC was applied, regardless of the consistency. However, the GCC consistency seems to not affect push-out bond strength. Further clinical studies are needed to better understand the impact of these findings on prosthesis longevity.

Immunosuppression and Outcomes in Patients with Cutaneous Squamous Cell Carcinoma of the Head and Neck.

Cutaneous squamous scell carcinoma (cSCC) is a frequent non-melanoma skin cancer that originates from keratinocytes with increased prevalence. cSCC can be either in situ, as in Bowen's disease, or extended. Advanced age, accumulated sun exposure, light pigmentation, and prior skin cancer diagnosis are all significant risk factors for cSCC. Although most cSCCs can be treated surgically, some recur and metastasize, resulting in death. The role of immune status is not yet determined in the prognosis of these patients. Objective. Immunosuppressed patients are more likely to develop cSCC, which is often characterized by more aggressive, multifocal lesions. This study aimed to determine the risks of mortality in patients with cSCC and immunosuppression versus non immunosuppression and to compare variations in overall survival based on different clinical features. Method. We evaluated clinical cases of patients at "Sfantul Apostol Andrei" Emergency Hospital of Galati, Romania, from 1 March 2018 to 1 April 2024. Subjects in the trial had to be at least 18 years old and have a pathologically confirmed diagnosis of cutaneous head and neck squamous cell carcinoma (cHNSCC). We divided the patients into two different categories based on whether they had immunosuppression. Results. In this cohort of 68 subjects with cSCC, patients with immunosuppression had significantly lower overall survival, as well as lower three- and five-year survival rates compared with those without immunosuppression, even after adjustment for age, sex, stage, and previous surgical treatment. The median survival time for immunosuppressed individuals ranged from 11 to 21 months, varying based on their particular characteristics, and most critically, on the presence of other malignancies, while that of immunocompetent patients ranged from 18 to 51 months. In addition, immune-deficient patients with early-stage disease had a 21-month median survival rate that changed to11 months for advanced-stage cases. In a similar manner, immunocompetent patients with early-stage cancer had a significantly better median survival than those withadvancedstages,43 versus 18months. Our results indicate that immunosuppression is a distinct risk factors associated with a less favorable outcome in patients with cHNSCC.

Genetic Mapping for Seed Aging Tolerance Under Multiple Environments in Sweet Corn

Seed vigor significantly impacts seed production and storage. Enhancing seed vigor is a pivotal goal in sweet corn breeding, as improved seed sowing quality is crucial for agricultural development, aiding in better resilience against storage adversities and facilitating long-term germplasm preservation. In this study, a recombinant inbred line (RIL) population, including 158 families, was derived from the aging-tolerant line K62 and the aging-sensitive line K107. Utilizing SNP arrays, genotypes were identified, and a genetic linkage map was constructed. Composite interval mapping was employed to detect quantitative trait loci (QTLs) associated with five seed vigor traits, namely the seedling fresh weight (SFW), germination potential (GP), germination rate (GR), germination index (GI), and vigor index (VI), at three days after artificial aging treatment. Upon analysis, a total of 42 QTLs affecting seed vigor indices were identified over two years. Of these, six were linked to SFW, while the GP, GR, GI, and VI each comprised nine QTLs. Nine QTL clusters were identified, with significant contributions (&gt;10%) from Loci02.1, Loci05.2, Loci06.1, and Loci10.1, ranging from 9.50% to 24.20%, 8.89% to 11.54%, 9.16% to 15.55%, and 7.54% to 17.77%, respectively. Candidate genes were explored within QTL cluster regions based on the aging-induced transcriptomic sequencing data of K62 and K107. Through Gene Ontology enrichment, gene annotation, and expression profiling clustering analyses, 12 positive candidate genes linked to seed aging tolerance were identified. This study provides a foundational understanding of the genetic mechanisms of seed aging tolerance and the innovation of an elite germplasm for seed aging tolerance in sweet corn.

Study on the Effect of Bee Venom and Its Main Component Melittin in Delaying Skin Aging in Mice.

Bee venom (BV) and its main compound melittin (MLT) have antioxidant, anti-inflammatory, and anti-aging activities; however, very little research has been conducted on their effects on skin aging. In this study, a mouse skin aging model induced by D-galactose was constructed via subcutaneous injection into the scruff of the neck, and different doses of BV and MLT were used as interventions. The anti-aging effects and mechanisms of BV and MLT were explored by detecting the skin morphology and structure, and anti-aging-related factors and performing non-targeted metabolomics of mice. BV and MLT improved dermal and epidermal thickness, boosted the collagen fiber content, increased hydroxyproline and hyaluronic acid levels, and enhanced transcript-level expression of IL-10, Col1a1, and Col3a1, while decreasing that of IL-1β. Metabolomic analysis showed that BV and MLT regulated the levels of some metabolites (compared to those in the skin aging control). BV effectively alleviated skin aging by regulating the pentose phosphate pathway, and pathways associated with carbon, galactose, and β-alanine metabolism, whereas MLT regulated pathways related to lipid metabolism, cholesterol metabolism, and atherosclerosis. This study highlights the potential applicability of BV and MLT in skin aging treatments and cosmetic products.

Cardiovascular Diseases, Vital Organ Fibrosis, and Chronic Inflammation Associated with High-Intensity and/or High-Volume Exercise Training: Double-Edged Sword Effects of Vigorous Physical Activity in Elderly People and/or in Middle-Age Cancer-Therapy-Treated Patients.

Cardiotoxicity, cardiovascular diseases (CVDs), hypertension, hepatotoxicity, and respiratory problems occurring several months to several years post-chemotherapy and/or radiotherapy are increasingly documented by scientists and clinicians. Anthracyclines, for example, were discovered in the late 1960s to be dose-dependently linked to induced cardiotoxicity, which frequently resulted in cardiomyopathy and heart failure. Most of those changes have also been associated with aging. While it is well known that exercise can slow down cellular aging processes, lessen the effects of chemotherapy, improve the effectiveness of cancer treatments, and prevent health problems in the general population, it remains unclear how exercise volume or intensity may affect the overall benefits of physical activity on health. For instance, higher rates of sudden cardiac arrest or coronary artery calcification have been found in marathon and ultra-marathon runners. Several additional pathological consequences have also been reported recently on many organs of those athletes. This review reports the most recent evidence suggesting that excessive intensity and/or volume may have deleterious effects on health. These findings are in clear contrast with the popular belief that all forms of physical activity can generally reduce the pathological changes associated with aging or cancer therapies. In conclusion, high-intensity training (HIT) and/or high-volume training (HVT) should not be recommended for middle-age and elderly people who have had cancer therapies or not in order to avoid an exacerbation of the consequences of aging or long-term cancer treatment effects on vital organ structures and functions.

Effect of Hot Deformation Plus Aging Treatment on the Microhardness of a TC18 Alloy

The effect of hot deformation plus aging treatment on the microhardness of a solid solution TC18 titanium alloy is investigated. First, the microstructure evolution during hot deformation and aging treatment stages is analyzed. Additionally, the influence of deformation parameters on microstructure evolutions of the aged alloy is further studied. After aging treatment, the alloy exhibits a trimodal microstructure, which contributes to its excellent mechanical performance. Aging treatment significantly refines the microstructure, which is also influenced by deformation parameters. The microhardness variations at different stages are subsequently analyzed and how deformation conditions affect the microhardness of the aged alloy is examined. Aging treatment substantially enhances microhardness through the precipitation of acicular α phases. Deformation parameters also have a significant impact. A predictive model for the microhardness of the aged alloy is established using machine learning methods, achieving high accuracy. This research is significant for tailoring the desired microhardness of TC18 alloys during die forging and subsequent aging treatment.