The observance of time-dose prescription is an important parameter of irradiation effect. Adequate patient support about acute reactions improves compliance to treatment. E-communication could represent an effective tool in addition to already given verbal and written information. An Internet advising project was designed for larynx cancer patients on radiotherapy involving survivors as a support group and health professionals as a monitoring team. This pilot study aims to assess the feasibility and to define the methodology of the project. All larynx cancer patients irradiated during the last two years were considered as a reliable image of the future target population, namely recently diagnosed cases entering their radiotherapy course. The 65 patients treated in 2002 and 2003 were included: 44 males and 21 females, aged 90 to 37 years (mean 65). Most of these cases were of poor socio-economic status. The help group consists of 15 survivors selected on a voluntary basis. Owing to the same diagnosis as the target population they received the same treatment. By comparison they are better educated and have a higher income. They use to be on Internet and are well aware of e-mailing, instant messaging and chat rooms. Hospital professionals constitute the electronic support team: head and neck radiation oncologist, nurses for health and psycho-social problems and an executive secretary in charged of e-communication aspects. Feasibility study addressed patients capabilities to communicate electronically from technical points of view as well as their personal needs and motivations. A questionnaire was designed to evaluate 14 major items with a total of 76 response opportunities by interview method. Physical accessibility to the Web is present among 71% of patients likely to be concerned by the project. 10% have no phone connection and 19% use a mobile only. 56% of cases have not any personal computer at their disposal, 20% could be direct users and 24% would be indirect ones through family and friends. Some extent of voice impairment is found once over four times. There is no French language difficulties nor misunderstanding even in Italian and Spanish speaking persons. 27% of patients need more cancer and treatment related information and 17% phoned to the caring team during irradiation period. The potential benefit is confirmed by 67% of the population and 64% would have been very interested in participating if the project had been operational at the time of their radiotherapy. Most of the patients (93%) give equal importance to communicate with health professionals as with the virtual community of survivors. 3% seek moral encouragement and exchange of personal experiences, 45% information only and 52% have both motivations. Among disinterested patients, number one reason (73%) is intimacy preservation while 20% of patients prefer face-to-face interactions and only 6% are unwilling to cope with technical aspects of computers because they do not feel comfortable. Interestingly, age does not seem to influence the decision to join the project. A project of rendering patients who undergo radiotherapy able to communicate electronically with both a help group of survivors and a team of health professionals is favourably considered by a majority of the target population. Physical accessibility to the Web is however far from being generalized. Providing free microcomputers constitutes a prerequisite and Internet training lessons are mandatory. E-mailing, instant messaging and chat rooms are thought as valuable tools to improve an insufficient information about cancer and treatment. When existing, disinterest is not linked to age nor technicality but to a preference for face-to-face interactions. If the requirements pointed out by the pilot study are fulfilled, e-communication could correlate to patients better compliance and quality of life. Without excluding the use of conventional modalities, our research will try to maximize the benefits of this challenging new area