Introduction. In connection with the emergence of a new coronavirus infection COVID-19, since 2020, a set of measures has been carried out in Moscow to ensure the identification, isolation and organization of the treatment process of patients with tuberculosis combined with COVID-19. Based on the data of the TB/COVID-19 co-infection monitoring system created in Moscow, the study analyzed all 430 confirmed cases of COVID-19 among TB patients registered or followed up in Moscow in 2021 in groups I and II of dispensary observation. Aim. To study the incidence of COVID-19 in tuberculosis patients in 2021 and to identify epidemiological features among tuberculosis patients in the second year of the pandemic. Results. The analysis showed that with an increase in the territorial incidence and an increase in the total number of newly diagnosed TB patients in the capital in 2020–2021, the number of confirmed cases of TB/COVID-19 co-infection decreased by 212 cases. Among all 430 patients, 52.3% are permanent residents of the city, 22.3% are residents of other subjects of the Russian Federation, 12.3% are homeless persons and 13.1% are foreign citizens. In 80.5% of cases, the diagnosis of coronavirus infection caused by the COVID-19 virus was established based on the results of etiological laboratory diagnostics (detection of SARS-CoV-2 RNA by PCR in smears with mucosa from the nasopharynx and oropharynx), and in other cases - only according to radiation diagnostics (computed tomography of the chest). More than half of those with combined tuberculosis/COVID-19 infection – 59.8% were unemployed and 14.4% were old-age pensioners. In 2021 in among tuberculosis/ COVID-19 patients, 63.3% (272 people) were newly diagnosed tuberculosis patients, of which: – 53.3% were permanent residents of Moscow, – 19.1% residents of other subjects of the Russian Federation, – 14.7% are homeless, – 9.9% are foreign citizens. For new tuberculosis cases, the maximum number of patients, co-infected with a new coronavirus infection was at the age of 31–45 years, which was somewhat different from the age characteristics of the incidence for other patients. Because of treatment of coronavirus infection, 84% of patients cured of COVID-19 already in 2021, 12.1% (52 people) died. The created tuberculosis/COVID-19 co-infection monitoring system in Moscow allows for a full assessment of the course of a new coronavirus infection in tuberculosis patients, patient routing, analysis of the incidence of COVID-19 among tuberculosis patients, the effectiveness of their treatment and the causes of mortality.