Treatment Of Uncomplicated Gonorrhea Research Articles

Treatment of gonorrhea: comparison of cefotaxime and penicillin

Ninety-seven patients with 118 sites infected with Neisseria gonorrhoeae were treated with a single dose of either procaine penicillin G (4.8 x 10(6) U) or cefotoxime (1.0 g) intramuscularly. Only the penicillin group took 1 g of probenecid orally. The numbers of infected sites in each treatment group were as follows: penicillin-urethra, 37; rectum, 9; cervix, 8; and pharynx, 4; cefotaxime-urethra, 42; rectum, 9; cervix, 5; and pharynx, 4. The cure rates in each treatment group were 100%. No adverse reactions were noted in either group. beta-Lactamase-positive N. gonorrhoeae strains were not found. Ninety-five percent of clinical isolates were inhibited by less than or equal to 0.007 micrograms of cefotaxime and less than or equal to 0.25 micrograms of penicillin per ml. In this study cefotaxime was as effective as procaine penicillin in the treatment of uncomplicated gonorrhea.

Comparison of Ampicillin plus Probenecid with Amoxicillin plus Probenecid for Treatment of Uncomplicated Gonorrhea

The efficacy of 3 g of amoxicillin plus 1 g of probenecid was compared with the efficacy of 3.5 g of ampicillin plus 1 g of probenecid for the treatment of uncomplicated gonorrhea. In a clinical trial no therapeutic failure was seen among 60 patients who were treated with the former regimen. The combination of ampicillin plus probenecid resulted in two therapeutic failures (3.6%) among the 55 patients given it. It was concluded that amoxicillin plus probenecid is as effective as ampicillin plus probenecid for the treatment of uncomplicated gonorrhea.

Treatment of uncomplicated gonorrhoea with spectinomycin hydrochloride (Trobicin).

110 patients with uncomplicated gonococcal urethritis were treated with 2 g spectinomycin (Trobicin) intramuscularly. Seventy-five patients were available for follow-up and there was only one treatment failure, giving a cure rate of 98-6%. Of the 99 gonococcal isolates, 59 were sensitive to 5 microng/ml of spectinomycin or less and 40 were sensitive to 10 microng/ml. In a small sample of patients 2 g spectinomycin intramuscularly produced a serum concentration averaging 100 microng/ml after one hour.

Oral talampicillin in the treatment of gonorrhoea.

Talampicillin was effective in eradicating the causitive organism in uncomplicated gonorrhoea, with only four treatment failures (1-6%) in 245 patients seen at least once after treatment. Symptoms, such as discharge, were seen in 61 patients at some stage after treatment but 31 of these cases were clear after one or two follow-up visits. The anitbiotic was well tolerated. One patient developed a maculopapular rash, penicillin allergy was reported in two patients, and a generalised itch (possibly penicillin allergy) in one further patient. A total of 241 out of 245 (98%) cases had the urethral gonococcus successfully eradicated with talampicillin. Talampicillin given in single doses appears to be an extremely good choice of antibiotic in the treatment of uncomplicated gonorrhoea in men.

Treatment of gonorrhea with cefazolin plus probenecid.

The cephalosporin group of antibiotics has a poor record in therapy of gonorrhea. In this study a new parenteral cephalosporin C derivative, cefazolin, was examined alone and with probenecid, and the two regimens were compared with aqueous procaine penicillin G plus probenecid in the treatment of uncomplicated gonorrhea. Two grams of cefazolin resulted in nine t ailures among 31 patients (29%). The same dose of cefazolin plus 1.0 g of probenecid resulted in six failures among 31 patients (19.3%). The control schedule of 4.8 X 106 units of aqueous procaine penicillin G plus 1.0 g of probenecid resulted in only one failure among 30 patients (3.3%). Levels of cefazolin were determined in sera of 10 patients; at 6 hr the mean serum level in patients who had received cefazolin plus probenecid was twice that in those who had received cefazolin alone. Serum levels of cefazolin were at least 10 times the mean minimal inhibitory concentration of cefazolin of 2.76 p[g/ml at 6 hr in eight of 10 subjects.

Spectinomycin hydrochloride in the treatment of uncomplicated gonorrhoea in males and females.

Spectinomycin hydrochloride in the treatment of uncomplicated gonorrhoea in males and females.

Treatment of Uncomplicated Gonorrhea in Women with a Single Oral Dose of Amoxicillin

Amoxicillin was used to treat acute uncomplicated gonorrhea; 89 women were given a single oral dose of either 3.0 g of amoxicillin or 2.0 g of amoxicillin plus 0.5 g of probenecid. The cervix, pharynx, and rectum of each patient were cultured, and the patients were asked to return for follow-up visits after three to five and seven to 10 days, when all three sites were again cultured. There was at least one follow-up examination on 82 of the 89 patients. The failure rate in patients denying reexposure to gonorrhea were 4.6% in those treated with the 3-g regimen and 10.5% in those receiving the 2-g regimen with probenecid. There were also three patients in each treatment group in whom the reisolations of gonococci at follow-up were felt to be due to reexposure to gonorrhea. Although 40% initially had positive rectal cultures, there were no failures at the rectal site. In contrast, two of four patients with pharyngeal gonorrhea were failures. It is concluded that the two single-dose oral regimens of amoxicillin are adequate therapy for uncomplicated genital and rectal gonorrhea in women but may not be adequate for pharyngeal gonorrhea. Amoxicillin has an antibacterial spectrum comparable to that of ampicillin [1]. The superior oral absorption of amoxicillin [2, 3] might allow oral treatment regimens for uncomplicated gonorrhea at least as effective as established single-dose oral ampicillin regimens. Possibly, the inconvenience and minor side effects of high-dose oral ampicillin regimens might be ameliorated by using lower doses of amoxicillin to achieve comparable serum levels of antibiotic. We decided to test the efficacy

Pivampicillin HCl-probenecid combination in the treatment of uncomplicated gonorrhoea.

Pivampicillin HCl-probenecid combination in the treatment of uncomplicated gonorrhoea.

A Comparison between Pivampicillin, Ampicillin and Penicillin G in the Treatment of Acute Uncomplicated Gonorrhoea

In the treatment of uncomplicated gonorrhoea pivampicillin, a recently introduced ampicillin derivative with improved oral absorption, has been compared with oral ampicillin and parenteral penicillin

Triple tetracycline ('Deteclo') as a single dose oral treatment of uncomplicated gonorrhoea in the male.

SummaryTwo hundred and sixty-nine patients suffering from acute gonococcal urethritis were treated with single oral doses (variable) of a triple tetracycline preparation (‘Deteclo’).In acute uncomplicated gonorrhoea, it was found that a single-session treatment with 1.2g. 'Deteclo' gave a failure rate of 6.2%. Side-effects were of a gastrointestinal nature and were not a serious hazard at that particular dosage. They were minimised by an antiemetic, viz. promazine hydrochloride or metaclopramide mono-hydrochloride.It would appear, therefore, that 'Deteclo' has all the advantages of any oral preparation which can be used in a single-session treatment of acute uncomplicated gonorrhoea. It should, therefore, be considered in this light as an effective, convenient, alternative treatment in uncomplicated male gonorrhoea.Because of frequent and often distressing side-effects, it was not possible to arrive at an acceptable single-session regime using 'Deteclo' in non-specific urethritis.

Penicillin in the Treatment of Gonorrhea?

To the Editor.— This is in answer to letters by Cobey, Handsfield, Riggs (220:419, 1972), Caldwell (219:620, 1972), and Hinman (220:589, 1972). Some clinic staffs may not mind the occasional risk of anaphylaxis in the treatment of uncomplicated gonorrhea, from injection of 4.8 million units of penicillin, or following Caldwell's advice of having these patients observed by resuscitation-trained and equipped personnel for 30 minutes. For private practitioners who see probably three fourths of all gonorrhea cases, the malpractice picture—guilt or no guilt—makes this an unattractive procedure. There are diseases in which such risks are justifiable; it is doubtful whether uncomplicated gonorrhea is one of them. How much syphilis is aborted by the liberal use of penicillin in gonorrhea? A clue to this can be found in the incidence of syphilis in gonorrhea cases in prenatal clinics. The chances are that most of these women, when examined, would be past the

Recommended treatment schedules for gonorrhea.

Diagnosis and Treatment1 June 1972Recommended Treatment Schedules for GonorrheaVENEREAL DISEASES BRANCH, STATE AND COMMUNITY SERVICES DIVISION, CENTER FOR DISEASE CONTROLVENEREAL DISEASES BRANCH, STATE AND COMMUNITY SERVICES DIVISION, CENTER FOR DISEASE CONTROLSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-76-6-991 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe preferred drug for Neisseria gonorrhoeae infection is penicillin or ampicillin. Physicians are cautioned to use no less than the recommended doses of antibiotics.For Treatment of Uncomplicated Gonorrhea (Urethral, Cervical, Pharyngeal, or Rectal)PARENTERALMen or women: aqueous procaine penicillin G, 4.8 million units intramuscularly divided into at least two doses and injected at different sites at one visit, together with 1 g of oral probenecid, preferably given at least 30 minutes before the injection.ORALMen or women: ampicillin, 3.5 g, with probenecid, 1 g, administered simultaneously.Treatment of ContactsPatients with known exposure to gonorrhea should receive... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Atlanta, Georgia▸Released in Morbidity and Mortality Weekly Report, 11 March 1972. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMale urethritis in King County, Washington, 1974-75: II. Diagnosis and treatment.Gonococcal and Nongonococcal Urethritis in Men Clinical and Laboratory DifferentiationNORMAN F. JACOBS Jr., M.D., STEPHEN J. KRAUS, M.D.Single Oral Dose of Ampicillin-Probenicid as Gonorrhoea Treatment: Antibiotic Levels in Urethral ExudateInfectious diseases: annual review of significant publications. 1 June 1972Volume 76, Issue 6Page: 991-991KeywordsAntibioticsDrugsGonorrheaMorbidityMortalityPenicillin Issue Published: 1 June 1972 PDF downloadLoading ...

Treatment of Gonorrhea

Broad spectrum antibiotics, given orally, were compared with penicillin for treatment of uncomplicated gonorrhea in male patients at the New Haven Health Department VD Clinic. Treatment success appeared more favorable with doxycycline than with penicillin, although the differences between the two drugs were not statistically significant. In addition to the acceptable therapeutic results, several public health considerations suggest the broad spectrum antibiotics as the drugs of first choice in the routine care of uncomplicated gonorrhea. Penicillin appears too valuable a drug to be used injudiciously for a disease which is as widespread and as likely to recur as gonorrhea.

Gonorrhea in women: treatment with sulfamethoxazole and trimethoprim.

After publication of a study describing the successful oral treatment of men suffering from uncomplicated gonorrhea with sulf amethoxazole-trimethoprim, this combination of drugs was used to treat women suffering from gonococcal urethritis and cervicitis. In every case, the diagnosis was confirmed by culture of Neisseria gonorrhoeae. Sulfamethoxazole-trimethoprim was given in the form of Bactrim (Roche) ; two tablets (each one containing 400 mg of sulf amethoxazole and 80 mg of trimethoprim) were taken night and morning for five days. One hundred and sixteen infections in 115 women were treated. Only two therapeutic failures were observed, and another two women were reinfected within a month of treatment, one on two occasions. Skin reactions to treatment were mild and infrequent. Hematologic investigation did not reveal any evidence of blood dyscrasias. This oral preparation can be recommended for the treatment of uncomplicated gonorrhea in women who can be relied upon to take it as directed.

Treatment of uncomplicated gonorrhoea with a single oral dose of doxycycline

No abstract available

Spectinomycin hydrochloride in the treatment of uncomplicated gonorrhoea.

Spectinomycin hydrochloride in the treatment of uncomplicated gonorrhoea.