Treatment Of Superficial Wounds Research Articles

Chitosan-Clay Mineral Nanocomposites with Antibacterial Activity for Biomedical Application: Advantages and Future Perspectives.

Polymers of natural origin, such as representatives of various polysaccharides (e.g., cellulose, dextran, hyaluronic acid, gellan gum, etc.), and their derivatives, have a long tradition in biomedical applications. Among them, the use of chitosan as a safe, biocompatible, and environmentally friendly heteropolysaccharide has been particularly intensively researched over the last two decades. The potential of using chitosan for medical purposes is reflected in its unique cationic nature, viscosity-increasing and gel-forming ability, non-toxicity in living cells, antimicrobial activity, mucoadhesiveness, biodegradability, as well as the possibility of chemical modification. The intuitive use of clay minerals in the treatment of superficial wounds has been known in traditional medicine for thousands of years. To improve efficacy and overcome the ubiquitous bacterial resistance, the beneficial properties of chitosan have been utilized for the preparation of chitosan-clay mineral bionanocomposites. The focus of this review is on composites containing chitosan with montmorillonite and halloysite as representatives of clay minerals. This review highlights the antibacterial efficacy of chitosan-clay mineral bionanocomposites in drug delivery and in the treatment of topical skin infections and wound healing. Finally, an overview of the preparation, characterization, and possible future perspectives related to the use of these advancing composites for biomedical applications is presented.

Loeselia mexicana: Antioxidant and antimicrobial properties by Soxhlet differential extraction

Loeselia mexicana or “Espinosilla” commonly known in Mexico is a plant with a great diversity of traditional medicinal uses, especially as an aid in the treatment of superficial wounds, however, said use lacks a scientific basis beyond ethnobotany, so studies of differential extraction that allowed to separate the secondary metabolites according to their polarity to carry out antioxidant tests, associated with the healing process and antimicrobial, associated with avoiding wound infection. The antioxidant potential is divided into two polarities with better results for those extracted by Ethanol (59.38% DPPH and 456.7 mg/kg Folin) and ethyl acetate (63.83% DPPH and 340.1 mg/kg Folin), indicating that both oily and alcoholic has metabolites that prevent skin oxidation; coinciding with the best inhibition halos in Gram negative bacteria. The use of medicinal plants in a traditional way cannot be stopped without affecting the traditions of the Mexican peoples and the world, however, with studies of differential extraction and evaluation of biological activity, it allows to establish scientific bases for its use and to continue to standardize it.

Maggot Therapy for Snakebite Necrotic Wound in a Horse

Maggot therapy is the use of sterile fly larvae in the treatment of superficial wounds in humans and animals. Lucilia sericata (Diptera: Calliphoridae) larvae are most commonly used for this purpose. Nowadays, larval therapy is widely used in the treatment of diabetic and infectious human wounds. Larval therapy in veterinary medicine has been used in dogs, cats, horses, and even ruminants. A 5-year-old crossbreed (Arabian and Kurdish) stallion was referred to a veterinary private sector in Tabriz city that suffered from a necrotic wound on its forelimb skin following a snakebite injury. The owner had seen the snake in the horse stable. Skin necrosis was observed on the dorsal of the right forelimb which extended to the ventral of the adjacent neck and chest. Despite this extensive skin injury, the horse was alert with a normal appetite and no sign of lameness was detected. Intravenous fluid therapy, systemic anti-inflammatory, and antibiotics were used for the horse's general condition support and topical oxytetracycline and zinc oxide were administered but had no effect on healing of necrotic wounds. Maggot therapy was performed on the necrotic skin. Unfortunately, the larvae died after inserting less than 24 hours. The maggot therapy was unsuccessful in the treatment of skin necrosis in this experience and the larvae died in this short time. However, more clinical trials on the efficacy of maggot therapy for extensive skin necrosis and studies on the effects of snake venom on the maggots are needed.

Synthesis of colloidal silver nanoparticles and their stabilization in several ways for external applications

Background . Today, many studies reflect an increase in the antibacterial effect of drugs through the use of a colloidal solution of silver nanoparticles. Creation of the various forms of drugs for an external use with a slow-release active component and antibacterial activity is relevant and promising for use in the treatment of superficial wounds and injuries. Objective . Synthesis and stabilization of quasispherical silver nanoparticles for external applications. Design and methods . The citrate method was used for the synthesis of colloidal silver. Dosage forms of external use were prepared by several methods: reaction with albumin, liposomal form, thickening with Aerosil and incorporation into microspheres. Results . Several methods of possible preparation of finished dosage forms based on colloidal silver nanoparticles have been demonstrated: reaction with albumin, liposomal form, thickening with Aerosil and incorporation into microspheres. Conclusion . Further investigation of both antimicrobial activity and cytotoxicity will reveal dosage forms with optimal efficiency/safety ratio.

Fundamentals of tissue viability, 1. Introduction

British Journal of Healthcare AssistantsVol. 11, No. 1 ClinicalFundamentals of tissue viability, 1. IntroductionMenna Lloyd JonesMenna Lloyd JonesSearch for more papers by this authorMenna Lloyd JonesPublished Online:12 Jan 2017https://doi.org/10.12968/bjha.2017.11.1.12AboutSectionsView articleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareShare onFacebookTwitterLinked InEmail View article References Butcher M, White R (2005) The structure and functions of the skin. In: White R (ed), Skin Care in Wound Management: Assessment and Treatment. Wounds UK, Aberdeen Google ScholarJones ML (2006) Treatment of superficial wounds and management of associated pain. http://tinyurl.com/jfyno3z (accessed 5 December 2016) Google ScholarJones ML (2014) Fundamental Care in Practice, Personal Hygiene. Series 3.2: anatomy and physiology of the skin. British Journal of Healthcare Assistants 8(8): 374–6 Link, Google ScholarPagnamenta F (2014) The role of the tissue viability nurse. Wound Essentials 9(2): 65–7 Google ScholarTimmons J (2006) Skin Function and Healing Physiology: Wound Essentials. http://tinyurl.com/lvjl4km (accessed 15 November 2016) Google ScholarTissue Viability Society (2014) Our Mission. http://tvs.org.uk/ (accessed 15 November 2016) Google ScholarVoegeli D (2007) Factors that exacerbate skin breakdown and ulceration. In: Skin Breakdown, The Silent Epidemic. Smith and Nephew Foundation, Hull. 17–21 Google ScholarVuolo J (2009) Wound care fundamentals. In: Vuolo J, Wound Care Made Incredibly Easy. Lippincott, Williams & Wilkins, London Google ScholarWounds UK (2012) Best Practice Statement: Care of the Older Person's Skin. 2nd edn. http://tinyurl.com/lfpmkmt (accessed 15 November 2016) Google Scholar FiguresReferencesRelatedDetailsCited byFundamentals of tissue viability, 1.5. Skin care: preventing skin tearsMenna Lloyd Jones11 May 2017 | British Journal of Healthcare Assistants, Vol. 11, No. 5Fundamentals of tissue viability, 1.2. Skin care: assessmentMenna Lloyd Jones8 February 2017 | British Journal of Healthcare Assistants, Vol. 11, No. 2 2 January 2017Volume 11Issue 1ISSN (print): 1753-1586ISSN (online): 2052-4420 Metrics History Published online 12 January 2017 Published in print 2 January 2017 Information© MA Healthcare LimitedPDF download

Honey as a promising treatment for diabetic foot ulcers (DFU)

Diabetic Foot Ulcers (DFUs) are complex, chronic wounds, which have a major long-term impact on the morbidity, mortality and quality of patients' lives. Individuals who develop a DFU are at greater risk of premature death, myocardial infarction, and fatal stroke than those without a history of DFU. Unlike other chronic wounds, the development and progression of DFU is often complicated by wide-ranging diabetic changes, such as neuropathy and vascular disease. These, along with the altered neutrophil function, diminished tissue perfusion, and defective protein synthesis that frequently accompany diabetes, present practitioners with specific and unique management challenges.Honey has been used for centuries in wound care. Its therapeutic properties are largely attributed to its antimicrobial and anti-inflammatory activities. This review provides an insight on the mechanisms by which honey affects wound healing. Honey is being used to treat many types of wound, including: traumatic wounds, surgical incision sites, burns, sloughy wounds, and pressure ulcers.The number of publications reporting the use of honey has increased. A great number of studies haves concluded that clinical evidence to support the use of honey in the treatment of superficial wounds and burns was of low quality. Other studies suggested that honey improved healing times in mild to moderate superficial and partial thickness burns when compared to conventional dressings.This was supported by a meta-analysis of systematic reviews of topical and systemic antimicrobial interventions for wounds. Of 109 evidence based conclusions, robust evidence was found to support the use of topical honey to reduce healing times in burns.Yet, there are many studies which did not indicate the positive result on using honey to treat DFU's. Therefore, more studies should be carried out in order to make a solid proof for using honey in treatment of DFU's.

Treatment of superficial wounds and management of associated pain

Treatment of superficial wounds and management of associated pain