Synthesis of colloidal silver nanoparticles and their stabilization in several ways for external applications

Abstract

Background . Today, many studies reflect an increase in the antibacterial effect of drugs through the use of a colloidal solution of silver nanoparticles. Creation of the various forms of drugs for an external use with a slow-release active component and antibacterial activity is relevant and promising for use in the treatment of superficial wounds and injuries. Objective . Synthesis and stabilization of quasispherical silver nanoparticles for external applications. Design and methods . The citrate method was used for the synthesis of colloidal silver. Dosage forms of external use were prepared by several methods: reaction with albumin, liposomal form, thickening with Aerosil and incorporation into microspheres. Results . Several methods of possible preparation of finished dosage forms based on colloidal silver nanoparticles have been demonstrated: reaction with albumin, liposomal form, thickening with Aerosil and incorporation into microspheres. Conclusion . Further investigation of both antimicrobial activity and cytotoxicity will reveal dosage forms with optimal efficiency/safety ratio.