Prototypes of SARS-CoV-2 virus “traps” based on enterosorbents

Abstract

Background. Despite the ongoing mutations of the SARS-CoV-2 virus, the causative agent of the COVID-19 disease, its mechanism of entry into the cell remains unchanged, which can be used to create virus “traps”. Intravenous medications aggravate the symptoms of the disease. An alternative means of combating the virus could be enterosorbents synthesized on nanosized carriers that intercept SARS-CoV-2 directly at the site of its introduction into the body, namely in the gastrointestinal tract. Objective. To study and refine the methods of synthesis of different spacer types on the surface of aerosil nanoparticles, immobilization of model protein with the possibility of using the compounds as enterosorbents of SARS-CoV-2 virus. Design and method. Aerosil A-200 grade was used as carrier nanoparticles. The chemical composition of the obtained compounds was studied by FTIR spectroscopy. The absorption spectra of the samples were studied using a spectrophotometer. The dimensions of nano-objects were determined by dynamic light scattering. Qualitative and quantitative determination of protein chemisorption on the synthesized particles was carried out. Results. Prototypes of SARS-CoV-2 enterosorbents on aerosil particles were developed. The efficacy of the spacers was tested on the model protein, albumin. Conclusion. Further research may be directed to the development of an oral drug that reduces the viral load of SARS-CoV-2.