Treatment Of Skin Diseases Research Articles

Artificial keloid skin models: understanding the pathophysiological mechanisms and application in therapeutic studies.

Keloid is a type of scar formed by the overexpression of extracellular matrix substances from fibroblasts following inflammation after trauma. The existing keloid treatment methods include drug injection, surgical intervention, light exposure, cryotherapy, etc. However, these methods have limitations such as recurrence, low treatment efficacy, and side effects. Consequently, studies are being conducted on the treatment of keloids from the perspective of inflammatory mechanisms. In this study, keloid models are created to understand inflammatory mechanisms and explore treatment methods to address them. While previous studies have used animal models with gene mutations, chemical treatments, and keloid tissue transplantation, there are limitations in fully reproducing the characteristics of keloids unique to humans, and ethical issues related to animal welfare pose additional challenges. Consequently, studies are underway to create in vitro artificial skin models to simulate keloid disease and apply them to the development of treatments for skin diseases. In particular, herein, scaffold technologies that implement three-dimensional (3D) full-thickness keloid models are introduced to enhance mechanical properties as well as biological properties of tissues, such as cell proliferation, differentiation, and cellular interactions. It is anticipated that applying these technologies to the production of artificial skin for keloid simulation could contribute to the development of inflammatory keloid treatment techniques in the future.

Principles and clinical applications of transcutaneous laser-assisted drug delivery: A narrative review.

Transcutaneous laser-assisted drug delivery (LADD) is recognized as a developing therapy for skin disorders. Current literature was reviewed to summarize current applications for LADD. 12 clinical applications for this therapy are currently reported. LADD has potential for wide application in skin disorder treatment. Laser assisted drug delivery improves drug bioavailability for treatment of skin disorders. This technique is being assessed clinically in disorders ranging from skin cancers to alopecia.

Essential Oil of Matricaria chamomilla Alleviate Psoriatic-Like Skin Inflammation by Inhibiting PI3K/Akt/mTOR and p38MAPK Signaling Pathway.

The traditional Matricaria chamomilla L. has been used to treat dermatitis for thousands of years. Due to emerging trends in alternative medicine, patients prefer natural remedies to relieve their symptoms. Therefore, finding safe and effective plant medicines for topical applications on the skin is an important treatment strategy for dermatologists. German chamomile (Matricaria chamomilla L.) from the Compositae family is a famous medicinal plant, often known as the "star of medicinal species."However, the function of Matricaria chamomilla essential oil on skin inflammation has not been thoroughly examined in earlier research. GC-MS analyzed the components of MCEO, and this study explored the anti-inflammation effects of MCEO on psoriasis with network pharmacological pathway prediction. Following this, we used clinical samples of psoriasis patients to confirm the secretory characteristic of relative inflammatory markers. The therapeutic effect of MCEO on skin inflammation was detected by examination of human keratinocytes HaCaT. At the same time, we prepared imiquimod-induced psoriatic-like skin inflammation in mice to investigate thoroughly the potential inhibition functions of MCEO on psoriatic skin injury and inflammation. MCEO significantly reduced interleukin-22/tumor necrosis factor α/lipopolysaccharide-stimulated elevation of HaCaT cell inflammation, which was correlated with downregulating PI3K/Akt/mTOR and p38MAPK pathways activation mediated by MCEO in HaCaT cells treated with IL-22/TNF-α/LPS. Skin inflammation was evaluated based on the PASI score, HE staining, and relative inflammatory cytokine levels. The results showed that MCEO could significantly contribute to inflammatory skin disease treatment. MCEO inhibited inflammation in HaCaT keratinocytes induced by IL-22/TNF-α/LPS, the potential mechanisms associated with inhibiting excessive activation and crosstalk between PI3K/Akt/mTOR and p38MAPK pathways. MCEO ameliorated skin injury in IMQ-induced psoriatic-like skin inflammation of mice by downregulating the levels of inflammatory cytokines but not IL-17A. Thus, anti-inflammatory plant drugs with different targets with combined applications were a potential therapeutic strategy in psoriasis.

ETNOBOTANI TANAMAN OBAT UNTUK PENGOBATAN PENYAKIT KULIT OLEH MASYARAKAT DI KELURAHAN SASA KECAMATAN TERNATE SELATAN

Ethnobotany is a field that studies how people in an area use various types of plants, one of which is for traditional medicine. This treatment is usually used traditionally in Indonesia, such as ointment, but no cure has been found. Sufferers ultimately decide to seek more scientific alternative medicine, which is usually known as traditional medicine, even though they continue to experience pain. treatment carried out by people who have skin diseases and use this plant to treat their skin diseases. This research aims to determine the ethnobotany of medicinal plants in the treatment of skin diseases by the community in Sasa sub-district, South Ternate District. This type of research is exploratory or exploratory descriptive research using survey, interview or questionnaire methods conducted in the Sasa sub-district, South Ternate District. The results of the research show that in Sasa sub-district there are 15 types of plants from 11 families that can be used as medicine for skin diseases. In the interview, the processing method was to mash, cut, and then apply the affected area. Seeds, rhizomes, leaves, fruit, stems and flowers are the parts of the plant used..Keywords : Etnobotani, Tanaman Obat, Penyakit Kulit

Profil Penyakit Kulit pada Pasien Anak yang Berobat di Poliklinik Kulit dan Kelamin RSUD Provinsi Nusa Tenggara Barat Periode Januari 2020–Juni 2023

Skin diseases can affect all ages, children are no exception. Skin diseases in children can cause considerable discomfort, parental anxiety, and embarrassment in children and impact on absenteeism rates in school-age children. The purpose of this study was to determine the statistical epidemiology of pediatric skin diseases so that they could provide information regarding the prevalence of the disease so that it could be a way to evaluate the causes of skin diseases to help prevent and treat skin diseases. This study using descriptive retrospective method from secondary data from medical records of children aged 0 to 18 years undergoing treatment at the Dermatology and Venereology Polyclinic at Nusa Tengara Barat Province Hospital in the period January 2020 - June 2023. Then processed with software for presentation in tabular form. During this period, there were 475 pediatric patients with 448 new patients and 27 old patients. Generally men numbered 282 (59.4%). The most common categories of skin diseases in children were infectious diseases with 288 cases (60.6%), dermato-allergo-immunology with 89 cases (18.7%) and non-infectious diseases with 59 cases (12.5%). Most skin diseases are caused by infections, mainly parasitic infestations (mostly scabies), fungal infections (mostly pityriasis versicolor) and followed by bacterial infections (mostly impetigo crustosa).

Bitter Phytochemicals as Novel Candidates for Skin Disease Treatment.

Skin diseases represent a global healthcare challenge due to their rising incidence and substantial socio-economic burden. While biological, immunological, and targeted therapies have brought a revolution in improving quality of life and survival rates for certain dermatological conditions, there remains a stringent demand for new remedies. Nature has long served as an inspiration for drug development. Recent studies have identified bitter taste receptors (TAS2Rs) in both skin cell lines and human skin. Additionally, bitter natural compounds have shown promising benefits in addressing skin aging, wound healing, inflammatory skin conditions, and even skin cancer. Thus, TAS2Rs may represent a promising target in all these processes. In this review, we summarize evidence supporting the presence of TAS2Rs in the skin and emphasize their potential as drug targets for addressing skin aging, wound healing, inflammatory skin conditions, and skin carcinogenesis. To our knowledge, this is a pioneering work in connecting information on TAS2Rs expression in skin and skin cells with the impact of bitter phytochemicals on various beneficial effects related to skin disorders.

Chitosan and its amphiphilic derivative nanoparticles loaded with Minoxidil for induction of hair growth: In vitro and in vivo evaluation

Minoxidil is widely used for treating Androgenic Alopecia, but its low hydrophilicity promotes the use of co-solvents in commercial formulations, which could then cause skin irritations. Nano-drug delivery systems have been developed to improve the solubility of lipophilic molecules and increase the concentration of drugs in hair follicles, thereby minimizing side effects. Chitosan (CS) and Methylated Aminobenzyl Carboxymethyl Chitosan (MCS) nanoparticles containing Minoxidil were prepared and evaluated for their physicochemical properties, drug release profile, skin permeation, cytotoxicity, and animal hair growth. The results showed that MCS nanoparticles had a 60 % drug release compared to CS nanoparticles, with almost complete release in 2 h. MCS nanoparticles also showed a 20 % drug permeation from skin compared to 70 % for CS nanoparticles in 24 h. In 48 and 72 h, CS and MCS nanoparticles didn't exhibit any significant cytotoxicity. Animal study revealed a significant increase in hair growth from MCS nanoparticles compared to the commercial formulation in fourteen days. However, MCS nanoparticles were less efficient compared to CS nanoparticles. The use of MCS in nano-drug delivery systems is expected to continue to gain importance due to its ability to enhance the solubility of hydrophobic drugs, particularly in the treatment of skin diseases.

Effect of propolis and polymer content on mechanical, bioadhesive and biological properties of nanostructured film forming platforms for topical drug delivery

Film form systems (FFS) composed of thermoresponsive and bioadhesive polymers have shown properties for the improvement of topical application. FFS are easy for administration, can increase the local residence time, control the drug delivery and improve the skin permeation. Propolis displays important biological properties like anticancer, healing, antimicrobial, antioxidant and can improve the structuring of FFS. It is a safe bioactive compound for wound healing and the treatment of skin diseases. However, propolis displays drawbacks for administration. The aim of this work was to evaluate the effect of polymeric and propolis composition on morphological, rheological, bioadhesive, drug release and skin permeation properties of designed FFS. In-vitro cytotoxicity, antitumoral and wound healing activity were also evaluated. Formulations composed of different amounts of polymers and propolis were proposed. The presence of propolis enhanced the bioadhesiveness and structuring of FFS. They displayed excellent capacity to form nanostructured film, displaying controlled propolis delivery and improved skin permeation. FFS were not cytotoxic and displayed in-vitro antitumoral activity and stimulated the cell migration. The selected preparations containing propolis extract (12%, w/w) and carbomer 974P or polycarbophil (0.25%, w/w) indicate a potentially advantageous role to be topically administered and suggest they are promissory formulations for clinical evaluation.

Skin Anti-Inflammatory Potential with Reduced Side Effects of Novel Glucocorticoid Receptor Agonists.

Glucocorticoids (GCs) are commonly used in the treatment of inflammatory skin diseases, although the balance between therapeutic benefits and side effects is still crucial in clinical practice. One of the major and well-known adverse effects of topical GCs is cutaneous atrophy, which seems to be related to the activation of the glucorticoid receptor (GR) genomic pathway. Dissociating anti-inflammatory activity from atrophogenicity represents an important goal to achieve, in order to avoid side effects on keratinocytes and fibroblasts, known target cells of GC action. To this end, we evaluated the biological activity and safety profile of two novel chemical compounds, DE.303 and KL.202, developed as non-transcriptionally acting GR ligands. In primary keratinocytes, both compounds demonstrated anti-inflammatory properties inhibiting NF-κB activity, downregulating inflammatory cytokine release and interfering with pivotal signaling pathways involved in the inflammatory process. Of note, these beneficial actions were not associated with GC-related atrophic effects: treatments of primary keratinocytes and fibroblasts with DE.303 and KL.202 did not induce, contrarily to dexamethasone-a known potent GC-alterations in extracellular matrix components and lipid synthesis, thus confirming their safety profile. These data provide the basis for evaluating these compounds as effective alternatives to the currently used GCs in managing inflammatory skin diseases.

Citrus Flavonones into nanotechnology-based formulations to skin treatment

Introduction: Flavonones show potential application in the treatment of skin disorders, whose performance may be improved by using lipid and polymeric nanocarriers. In this review, a recent approach regarding nanocarriers containing either naringin, naringenin, hesperidin or hesperitin for skin application are discussed. Method: This review approaches the publications from the last 6 years about nanosystems containing Citrus flavonones for cutaneous applications. The articles were selected by searching in Scopus database for nanosystem containing either hesperidin, hesperitin, naringin or naringenin for cutaneous application, research articles written in English and published between 2018 and 2023, and reporting about skin penetration or biological evaluation. Results: Majority of reports employed lipid systems as nanocarriers. Naringenin was the most used flavonone. In relation to skin benefits, improved wound healing, atopic dermatitis treatment and stress oxidative-related diseases are highlighted. Despite the probable benefits, the development of plant-based nanomedicines is complex, which imposes limitations on the development of new pharmaceutical products. Further, the potential of flavonoids in the treatment of skin cancer has been shown. Conclusions: Lipid, polymeric and nanohybrid carriers are employed to deliver flavanones. Due to their antioxidant and anti-inflammatory activities, flavanones bear potential applications in the treatment of different skin disorders. Therefore, there is a promising application of flavanones to the improvement of human health, mainly with their loading into nanocarriers.

Literature review interpretation of novel bacteriophage treatments for skin diseases

The justification for researching novel treatments with bacteriophages for skin diseases lies in the urgent need to overcome the challenges posed by antibiotic resistance. The aim of this study was to interpret, through bibliographic review, novel treatments with bacteriophages in skin diseases. A comprehensive search strategy was developed in highly recognized academic and scientific databases, including PUBMED, MEDLINE, Scopus, Clinical Key, and Web of Science. The selection of key terms was based on an iterative process that included "bacteriophages", "phages", "treatment", "phage therapy", "skin diseases", "dermatology", and "clinical applications". This strategy was complemented by the application of filters to restrict the results to publications between the years 2019 and 2023. The results of the reviewed studies suggested clinical resolution in approximately half of the cases treated with phage therapy, highlighting its effectiveness against resistant bacterial infections. However, it was noted that more rigorous clinical trials were required to establish its long-term efficacy and safety. The emerging bacteriophage therapy industry showed a diversity of companies and strategies, promoting its growth in the medical community. It was concluded that bacteriophages represent a promising addition to the medical arsenal and a hopeful response to antimicrobial resistance. The review reflected how science and medicine collaborated to address a crucial global challenge, offering innovative solutions in the treatment of bacterial infections

Herbal Drugs Used in Treatment of Skin Disease

Skin Affections are severe and a regularly going on fitness trouble affecting every age from the babes to the aged and reason damage in volume of ways. Maintaining healthy pores and skin is critical for a healthy body. numerous mortal beings might also also expand pores and skin affections that have an effect on the pores and skin, similar as cancer, herpes and cellulitis. Some wild foliage and their factors are regularly used to deal with those affections. The use of foliage is as quaint because the humanity. Natural remedy is nicely- priced and claimed to be secure. It's likewise applicable raw fabric for manufacturing of rearmost artificial agents. A estimate of a many foliage for the remedy of pores and skin affections is furnished that summarizes the current specialized advancements which have taken region on this region each through the beyond 17 times. Herbal wares these days are taken into consideration as a unattached line of remedy for lots affections like Cancers, Diabetes, Cardiovascular and Brain diseases, thereby developing recognition concerning chastity, efficacity and protection of natural medicines for fitness care operation. numerous therapeutically lively herbal natural sources like Aloe, Neem, Liquorice, Tulsi, Amla, Papaya, Ginger and Eucalyptus are amazing and secure with inside the remedy of dermatological infections. This estimate composition summarizes the significance of natural foliage for guarding, treating and minimizing pores and skin infections via the operation of natural tradition medicines like creams, decocted excerpts, cataplasm, paste and creams that resource with inside the remedy of pores and skin infections and affections at a fairly drop figure with lower aspect consequences compared to trendy and allopathic medicines. Keywords Ethnomedicine,sauces, medicinal foliage, pores and skin sicknes.

The mechanism of Chebulae Fructus Immaturus promote diabetic wound healing based on network pharmacology and experimental verification

Ethnopharmacological relevanceDiabetic ulcers (DUs) are commonly seen in the lower limbs, especially the feet. Long-term hyperglycaemia in diabetic patients may cause peripheral microvascular damage, which affects local blood flow reconstruction when the skin is ruptured. This results in delayed or even non-healing of skin wounds. Chebulae Fructus Immaturus (CFI) is a traditional Chinese medicine. According to traditional Chinese medicine theory, CFI belongs to the lung channel and large intestine channel. Clinical data confirm a significant clinical effect of CFI in the treatment of skin diseases. CFI can be safely used to treat wounds due to its natural active ingredients. Aim of the studyThis study utilised HPLC-ESI-QTOF-MS/MS combined with network pharmacology to investigate the mechanism of Chebulae Fructus Immaturus extract (CFIE) in the treatment of DU. Moreover, the efficacy of CFIE on DU was verified in vitro and in vivo by constructing cell models and mouse models. Materials and methodsThe main ingredients of CFIE were identified by HPLC-ESI-QTOF-MS/MS. The targets of these ingredients were predicted by database analysis and intersected with the DU targets. Gene ontology (GO) was used for functional enrichment of differential genes, and the Kyoto Encyclopedia of Genes and Genomes (KEGG) was used for enrichment of signalling pathways related to the differential genes. The network pharmacology findings were validated in vivo and in vitro, and the affinity of key targets and active components was assessed using molecular docking. ResultsTwenty-nine compounds of CFIE were identified by HPLC-ESI-QTOF-MS/MS, and their potential targets were predicted. Among these, 41 targets were associated with DU. KEGG enrichment analysis showed that the PI3K/AKT and HIF-1α signalling pathways were significantly enriched, which may be related to the promotion of wound angiogenesis. In vitro cell experiments showed that CFIE promoted the proliferation, migration and angiogenesis of HUVECs, and also affected the expression of pathway-related proteins. In vivo experiments showed that CFIE increased the expression of pathway-related proteins in wound tissue and promoted the formation of blood vessels. ConclusionsIn summary, this study systematically demonstrated the possible therapeutic effects and mechanisms of CFIE on DU through network pharmacology analysis and experimental verification. The results revealed that CFIE can accelerate the angiogenesis of diabetic wounds through the PI3K/AKT and HIF-1α signalling pathways, ultimately promoting the healing of diabetic wounds.

Formulation and Evaluation of Gel Containing Nigella sativa Seed Extract Loaded Transferosomes for Effective Treatment of Psoriasis

Background: Psoriasis vulgaris is an autoimmune associated skin disease causing plaques or scales formation where the skin cells form quicker than in their typical life cycle. The phenolic phytoconstituents reported in Nigella sativa are effective for the treatment of skin disorders. Transfersomes is an emerging nanoencapsulation drug delivery approach which can squeeze themselves due to its elastic nature as an intact vesicle across narrow pores. It improves the potency of topical formulations with higher permeation efficiencies compared to other vesicular drug delivery systems. Objective: This research work focused to prepare Nigella sativa or black seed extract loaded transfersomes as nanoformulation and further incorporating them in the gel system to give improved therapeutic efficacy due to their self-regulating and self-optimizing capabilities. Methods: The phenolic content of Nigella sativa or black seed was extracted in ethanol and the solvent was removed using a vacuum with suitable storage conditions at 22ºC. Transfersomes of ethanol extract were prepared by thin layer hydration method and further incorporated into gel formulations. The ant-psoriasis activity of prepared gel formulation was performed with histopathology study in the Imiquimod induced albino rat model. Results: A nanoformulation prepared with 0.85 mg lecithin and 0.10 mg tween 80 has the highest entrapment efficiency. The entrapment efficiency, vesicle size, polydispersity index and zeta potential of optimized transferosomes batch were found to be 69.3 ± 2.6%, 178 ± 11 nm, 1.1 ± 0.2, -29.4 mV, respectively. Anti-psoriatic activity of N. sativa seed extract loaded transfersomes showed a more significant reduction in thickness of the epidermis and less elongation of rete ridges with capillary loop dilation as compared to conventional gel formulation. Conclusion: We concluded that the Nigella sativa seed ethanolic extract loaded transfersomes gel formulation showed significant ant-psoriasis activity in an albino rat model.

Uric acid–reducing efficacy of Plectranthus amboinicus (Lour.) Spreng in mice with potassium oxonate-induced hyperuricemia

Plectranthus amboinicus (Lour.) Spreng is a type of Lamiaceae perennial herb that is widely used in folk treatments for respiratory and skin diseases. Notably, research on the hypouricemic effect of P. amboinicus is limited. This study investigated the uric acid–reducing efficacy of P. amboinicus in mice with potassium oxonate-induced hyperuricemia by performing an in vitro xanthine-oxidase-inhibition-activity-guided test of P. amboinicus extract (PAE) and its fractions. The ethyl acetate fraction (EAF) of PAE exhibited optimal efficacy in terms of the phenolic content, DPPH scavenging activity, and xanthine oxidase inhibition. We further demonstrated the uric acid–reducing activity of EAF in a mouse model of potassium bromate–induced hyperuricemia. The results can serve as a useful preclinical reference for researching the gout prevention effects of functional foods.
 Keywords: Plectranthus amboinicus (Lour.) Spreng, hyperuricemia, uric acid–reducing activity

Potential of Mushrooms Bioactive for the Treatment of Skin Diseases and Disorders

Potential of Mushrooms Bioactive for the Treatment of Skin Diseases and Disorders

Assessment of owner perceptions of caregiver burden, veterinarian-client relationship and satisfaction with the provider in canine pruritus: An experimental vignette study.

Complicated treatments for skin disease are linked to owner-caregiver burden and poorer perception of the veterinarian-client relationship, regardless of disease severity. Using experimental vignettes, we explored the impact on owner perception of the interaction of treatment complexity and skin disease outcomes. We hypothesised that: (i) vignette conditions involving injection therapy would result in lower burden, better veterinary-client relationship and greater satisfaction relative to multimodal therapy conditions; (ii) the vignette condition of injection therapy with a completely effective outcome would be superior to all other conditions; (iii) ineffective vignette conditions would be inferior to all other conditions; and (iv) the vignette condition injection with a mostly effective outcome would be similar or superior to the multimodal therapy with a completely effective outcome condition. Three hundred and nine owners of pruritic dogs recruited from a general veterinary practice, pet-related podcast, or social media dog allergy group. Participants were presented with six counterbalanced online vignettes representing three levels of treatment effectiveness (Completely Effective, Mostly Effective, Ineffective) and two treatment regimens (Multimodal, Injection). Measurements of participant perceptions of caregiver burden, veterinarian-client relationship and satisfaction were recorded. Injection with perfect outcome was superior to other conditions (p < 0.001). Conditions with poor effectiveness were inferior (p < 0.001). Comparison of Injection with a mostly effective outcome to Multimodal treatment with perfect outcome yielded small-to-medium effects of preference for the latter in veterinarian-client relationship and satisfaction (p < 0.01); no difference was observed for caregiver burden. When good effectiveness was assured, injection was preferred (p < 0.001). Owners preferred a Completely Effective outcome and were prepared to select the Injection regimen or Multimodal therapy to achieve this; Injection was preferred when effectiveness was assured.

Pharmaceutico-Analytical and Antimicrobial Study on Pruthvisar Tailam

Pruthvisar Tailam is one of the herbal preparations mentioned in Bhaishajya Ratnavali for the treatment of skin diseases. This is one of the rare formulations prepared by different and unique pharmaceutical process. This oil is prepared by Suryapakam process (oil and ingredients are mixed and subjected to strong sunlight till desired resultant is obtained). Sneha is a best media which can pass easily through the lipid membrane present in the skin. However very few research work has been done on this oil and oil based on Suryapakam process, also there is lack of enough analytical, anti-microbial and clinical evidences on the efficacy of the oil in skin ailments. Hence Pruthvisar Tailam is emerged as better and efficacious option for skin ailments with unique pharmaceutical procedure.

Medicinal Plants for Dermatological Diseases: Ethnopharmacological Significance of Botanicals from West Africa in Skin Care

Skin disease is a severe health issue that affects a lot of people in Africa and is vastly underreported. Because of their availability, affordability, and safety, medicinal plants represent a major source of treatment for various skin diseases in West Africa. This review presents the medicinal plants used in treating skin diseases in West Africa and their available biological activities that have lent credence to their skin care usage. A total of 211 plant species from 56 families are implicated to be used in West Africa for several skin conditions such as aphthous ulcers, burns, eczema, scabies, sores, and wounds. Fabaceae is the most-implicated family (30 species) for the treatment of skin diseases, followed by Combretaceae (14 species) and Asteraceae (13 species). Most of the medicinal plants used are trees (93); leaves (107) were the most-used plant part, and decoction (73) was the preferred preparation method for the medicinal plants. The biological activities related to the pathology of skin diseases, such as antimicrobial and anti-inflammatory properties of 82 plants, have been evaluated. Based on their minimum inhibitory concentration, the most active antimicrobial plant is Brillantaisia lamium. Among the isolated phytochemicals, betulenic acid and lespedin were the most active, while plants such as Kigelia africana and Strophanthus hispidus showed significant wound-healing activities. This review highlights research gaps in the ethnobotanical studies of many West African countries, the biological activities of plants used to treat skin diseases, and the cosmetic potential of these plants.

Pharmacological Effects of Shikonin and Its Potential in Skin Repair: A Review.

Currently, skin injuries have a serious impact on people's lives and socio-economic stress. Shikonin, a naphthoquinone compound derived from the root of the traditional Chinese medicine Shikonin, has favorable biological activities such as anti-inflammatory, antibacterial, immunomodulatory, anticancer, and wound-healing-promoting pharmacological activities. It has been reported that Shikonin can be used for repairing skin diseases due to its wide range of pharmacological effects. Moreover, the antimicrobial activity of Shikonin can play a great role in food and can also reduce the number of pathogenic bacteria in food. This paper summarizes the research on the pharmacological effects of Shikonin in recent years, as well as research on the mechanism of action of Shikonin in the treatment of certain skin diseases, to provide certain theoretical references for the clinical application of Shikonin, and also to provides research ideas for the investigation of the mechanism of action of Shikonin in other skin diseases.