Treatment Of Pulmonary Vascular Disease Research Articles

Lung transplantation.

Solid-organ transplantation has flourished during the last decade, with transplantation of heart and lungs becoming available to patients with end-stage cardiac or pulmonary diseases. The first lung transplant was performed in 1963 on a 58-year-old man with bronchogenic carcinoma. He survived for 18 days. During the next two decades, approximately 40 lung transplant procedures were attempted without success. These early attempts at lung transplantation were unsuccessful because of the development of lung rejection, anastomotic complications, or infection in the transplant recipients. In the early 1980s, human heart-lung transplantation was successfully performed for the treatment of pulmonary vascular disease. After this procedure, single-lung transplantation for the treatment of end-stage interstitial lung disease and obstructive lung disease was developed. More recently, the technique of double-lung transplantation has come into existence. This article reviews various aspects of lung transplantation, including immunosuppression, lung graft preservation, the various surgical techniques and types of lung transplant procedures available, recipient and donor selection criteria, and postoperative care of the transplant recipient. In addition, infectious and noninfectious complications seen in this particular patient population, including acute and chronic rejection, will be discussed.

Birth Defects, Original Article Series: Vol VIII, No. 1 Feb 1972, Congenital Cardiac Defects—Recent Advances

This book consists of 15 articles contributed by 29 authors. Its editors are Daniel Bergsma and Sidney Blumenthal. The contributors have written about subjects in which they have special interest. The topics are presented in random order and are concerned with aspects of congenital heart disease. The diagnosis and treatment of pulmonary vascular disease are discussed by Dr. Julien Hoffman. Dr. Abraham Rudolph relates his observations on coarctation of the aorta in the fetal and neonatal periods. Dr. Norman Talner describes the adjustment in the neonate and young infant to a congenital cardiac defect. Dr. Dan McNamara et al present their experience in the management of total anomalous pulmonary venous return in the young infant. Dr. William Rashkind tells about the natural and unnatural history of transposition of the great vessels. Kiechel, Blumenthal, and Griffiths describe a syndrome of papillary muscle infarction and dysfunction in infants. Techniques in the