Treatment Of Postacne Scars Research Articles

Nanofat Injection versus Platelet Rich Plasma with Glutathione Injection in the Treatment of Post-Acne Scars

Nanofat Injection versus Platelet Rich Plasma with Glutathione Injection in the Treatment of Post-Acne Scars

Unlocking the potential of microbotox compared with fractional carbon dioxide laser in the treatment of postacne scars: a comparative split-face study

Unlocking the potential of microbotox compared with fractional carbon dioxide laser in the treatment of postacne scars: a comparative split-face study

Microneedling with platelet-rich plasma versus microneedling with vitamin C in treatment of acne scars: comparative study

Background and aim Postacne scars may affect about 95% of patients with past history of acne that is related to its duration and severity of. Treatment of acne scarring is challenging. Microneedling with platelet-rich plasma (PRP) or vitamin C is a new, simple, and effective treatment modality for such scars. The authors aimed to compare between microneedling plus PRP versus microneedling plus vitamin C in treatment of postacne scars. Patients and methods This is a comparative study that was carried out on 20 patients (their ages ranged from 22 to 37 years). They are four males and 16 females, they presented with postacne scars. The patients were divided randomly to receive microneedling plus PRP on one side of the face, and microneedling plus vitamin C on the other side. Results The authors found a significant improvement of atrophic acne scars, with significant reduction in the number of acne scars as well as Goodman score after treatment by microneedling plus PRP as well as microneedling plus vitamin C, moreover, most of the patients were satisfied after treatment with no significant difference between both treatment methods. Microneedling with PRP and vitamin C was well-tolerated with no major adverse events that were observed. Conclusion PRP as well as vitamin C combined with microneedling is a safe, effective, and promising option in treatment of acne scars.

MULTITHERAPY PROTOCOL FOR THE TREATMENT OF ACNE SCARS - CASE REPORT

Acne scars are one of the most common skin diseases and can affect people’s quality of life, so it has increased the search for treatments that can reduce or solve this imperfection. Several studies have been proposed with different onliest or combined therapies, including microneedling associated with PRP. The main objective of this study was to describe a clinical case of a treatment of post acne scars through the microneedle associated with PRP and iPRF activated with oZônio. The results showed improvement in texture and softening in post acne scars. It can be concluded that microneedle treatment associated with ozone-activated PRP and is safe and efficient in the treatment of post-acne scars.

A prospective study on the efficacy and safety of fractional carbon dioxide laser in the treatment of post-acne scars

Introduction Acne scars can play havoc with the social functioning of the patient leading to severe depression with reduced quality of life. Fractional CO2 laser provides a fine balance between the undesirable side effects of ablative lasers and the limited efficacy of nonablative lasers. Objective The present study was conducted to evaluate the efficacy and safety of fractional CO2 laser in the treatment of acne scars. Patients and methods Fractional CO2 laser treatment performed on 30 patients with atrophic acne scar by different protocols depending on the type and its depth. Results were assessed based on serial photographs, clinical improvement, and physician’s global assessment scale. Results Of the 30 participants, 27 completed all three sessions. Out of the 27 patients in the final follow-up, three (10%) had excellent improvement of which two had mild acne scar and one had moderate scar before treatment; 16 (59.2%) had good response of which 13 had moderate acne scar and three had mild scar and eight (29.7%) had fair response of which six had moderate scars and two had mild scars. Conclusion Fractional CO2 laser as monotherapy in the treatment of mild-to-moderate post-acne scars seems to be effective with good patient satisfaction and reduced side effect profile. In case of severe acne scars, fractional CO2 laser can be used as a combined procedure along with other therapeutic modalities like subcision, platelet-rich plasma, and TCA CROSS (chemical reconstruction of skin scars using trichloroacetic acid) techniques.

Comparative study between the efficacy of botulinum toxin type A versus carboxytherapy in the treatment of postacne scars

Background Acne scarring remains a challenge to treat. Both botulinum toxin type A (BTX-A) and carboxytherapy (CXT) are considered novel treatment modalities for acne scars. Aim This study aimed to compare the efficacy and safety of BTX-A versus CXT in the treatment of postacne scars. Patients and methods Forty patients aged 18–50 years, with mild to severe postacne scars, were enrolled in this study and were divided randomly and equally into two groups: group A included 20 patients who underwent three sessions of an intralesional injection into postacne scars by BTX-A at a 3-week interval and group B included 20 patients who underwent three sessions of CXT on postacne scars at a 3-week interval. Evaluation of the clinical response to treatment was performed every 3 weeks and 1 month after the last session by photos and the global scarring grading system and patient satisfaction was assessed. Results There was a significant improvement in the degree of scar severity before and after treatment in both groups. There was no significant difference between improvements in both groups, indicating that both modalities of treatment yielded similar net results. Conclusion Both BTX-A and CXT can be effective and safe therapeutic options for the treatment of postacne scars with no significant side effects.

Split-face comparative study of fractional Er:YAG laser versus microneedling radiofrequency in treatment of atrophic acne scars, using optical coherence tomography for assessment.

Efficacy and safety of ablative fractional laser used for treatment of acne scars have been described in several studies. Recently, microneedling radiofrequency treatment has been showing promising results with low risk of side effects and rapid healing time. To study efficacy and safety of ablative fractional Er:YAG laser 2940nm and microneedling radiofrequency for facial atrophic acne scar. 21 patients with atrophic postacne scars were randomized to MRF for one half of the face and laser for the other half. Four sessions were performed monthly. For evaluation, the validated scale "Quantitative Global Grading System for Postacne Scarring" and patient's satisfaction were used before and 3months after treatment. Optical coherence tomography imaging of the skin was used as an objective tool for assessment. Both sides showed significant improvement on clinical evaluation with no significant difference. Optical coherence tomography assessment showed significant increase of both epidermal and dermal thickness compared to baseline. Both MRF and ablative fractional Er. YAG laser 2940nm are effective in the treatment of post acne scars. Microneedling radiofrequency is better tolerated, with lower downtime and fewer side effects.

Анализ современного состояния перспектив использования косметических средств для борьбы с последствиями акне содержащих муцин

In the course of research of scientific literature and patent documentation, a comparative analysis was carried out to identify the most effective, competitive cosmetic product containing snail mucin for the treatment of post-acne scars.

Split-face Comparative Study of Efficacy of Platelet-rich Plasma Combined with Microneedling versus Microneedling alone in Treatment of Post-acne Scars.

Context:Skin conditions contribute substantial burden toward global morbidity and mortality. Acne vulgaris, with its rising prevalence, has become a cause of concern among researchers as well as dermatologists due to scarring.Aims:The aim of this study was to compare the efficacy of microneedling alone versus microneedling combined with platelet-rich plasma (PRP) in post-acne scars using a split-face method.Materials and Methods:Thirty patients with atrophic post-acne facial scars were offered four sittings of treatment monthly once. As a standard protocol, the right side of the face was subjected to microneedling with PRP (Group A) and the left side of the face with microneedling alone (Group B). Objective evaluation of improvement was performed by the physician recording the acne scar assessment score at baseline and thereafter at every visit using Goodman and Baron scale. Alongside patients also graded the improvement in acne scars at the end of the study.Statistical Analysis Used:The collected information was entered in MS Excel (Bellevue, WA, USA) and analyzed using appropriate statistical methods with Statistical Package for the Social Sciences software (IBM Corp., Armonk, NY). The significance of the outcomes of the study was assessed by calculating the P value and the value of P < 0.05 was considered statistically significant.Results:The mean age of patients was 25 years. Thirteen (43%) patients in Group A had an excellent response as compared to 6 (20%) patients in Group B according to physician assessment. Patient’s satisfaction was more in Group A as compared to Group B as 11 (36%) patients had more than 75% improvement in Group A as compared to 1 (3%) patient in Group B.Conclusion:The study showed a decrease in scar severity grade in all the patients enrolled for treatment. However, the combined use of microneedling and PRP was found to be more effective than a single method used for treatment of acne scars.

Comparison of the efficacy of Subcision with Fractional Carbon Dioxide Laser versus Subcision with Microneedling Fractional Radiofrequency in the Treatment of Atrophic Post acne Scars

Background: Many interventions have been used to treat post-acne scars, with various degrees of efficacy and adverse reactions. Multimodal approach can achieve better results for improving the physical appearance that even if minor may result in significant distress and reduced quality of life. Objective: To compare the efficacy of subcision with fractional carbon dioxide (CO2) laser and subcision with microneedling fractional radiofrequency (RF) in treating post-acne scars and to study their adverse effects. Methods: In this prospective, interventional clinical study, a total of 64 patients with post-acne scars were enrolled. The patients were randomly allocated into two groups of 32 patients each, in which group A was treated with subcision plus fractional carbon dioxide laser (CO2) and group B was treated with subcision plus microneedling fractional radiofrequency (RF) every 6 weeks for a total of four sittings. An objective score was calculated for each patient using the Goodman and Baron scale to evaluate the outcome every visit during treatment and then 3 months after completion of therapy. Results: In group A, the percentage reduction in the mean objective scores was found to be 64%. In group B, the percentage reduction in mean objective scores was found to be 42%. Most of the changes were seen in the boxcar and rolling types of scars. Conclusions: Subcision and fractional CO2 laser were considered superior over subcision with microneedling fractional (RF) technique for the treatment of post-acne scars. Boxcar and rolling types of scars showed a high response to treatment than icepick scars

Micro Needling with Platelet Rich Plasma Versus Fractional CO2 Laser with Platelet Rich Plasma in Patients with Post Acne Scars

Background: Facial scaring has always been challenged to treat and there are many treatments available to decrease the appearance of scars like topical retinoids, chemical peeling, microneedling, dermabrasion, soft tissue fillers, botulinum toxoid injection and laser resurfacing The aim of this study was to evaluate and compare the efficacy of microneedling and fractional CO2 laser in the treatment of post acne scars. A comparative studyOf thirty patients (12 males and 18 females) aged 19 – 36 years with atrophic acne scars were devided into Group (A): treated with Fractional Co2 laser combined with topical platelet rich plasma. Group (B): treated with skin microneedling combined with topical platelet rich plasma. Platelet rich plasma can improve the quality of atrophic acne scars treated with ablative fractional CO2 laser or microneedling and decrease the duration of related side effects including oedema and erythema. Regarding patient’s satisfaction grades there was an improvement after both treatment modalities with insignificant differences between both treatment modalities. PRP can improve the quality of atrophic acne scars treated with ablative fractional CO2 laser or microneedling and decrease the duration of laser-related side effects including oedema and erythema.

A comparative study of efficacy of resurfacing with fractional carbon dioxide laser versus derma roller in the treatment of post acne scars

&lt;p class="abstract"&gt;&lt;strong&gt;Background:&lt;/strong&gt; Acne vulgaris is a chronic skin disease which can present as non-inflammatory lesions, inflammatory lesions, or a mixture of both, resulting in distressing and difficult to treat scars. The objective of this study is to compare the efficacy of fractional carbon dioxide (CO&lt;sub&gt;2&lt;/sub&gt;) laser technique (FCLT) versus derma roller therapy (DT) with respect to post-acne scars and to study their respective side effects.&lt;/p&gt;&lt;p class="abstract"&gt;&lt;strong&gt;Methods:&lt;/strong&gt; A total of 200 patients of post acne scars were enrolled for this study from the outpatient Department of Dermatology, Venereology and Leprology, Navodaya Medical College Hospital and Research Centre, Raichur. The patients were randomly allocated into two groups of 100 patients each in which one group was treated with derma roller therapy and the other group was treated with fractional CO&lt;sub&gt;2&lt;/sub&gt; laser every 4 weeks over a period of 24 weeks each.&lt;strong&gt;&lt;/strong&gt;&lt;/p&gt;&lt;p class="abstract"&gt;&lt;strong&gt;Results:&lt;/strong&gt; In the derma roller group, 89 patients completed the treatment with 11 drop out cases. The percentage reduction in the mean objective scores was found to be 37.63%. In the fractional CO&lt;sub&gt;2 &lt;/sub&gt;laser group, 93 patients completed the treatment with 7 drop out cases. The percentage reduction in mean objective scores was found to be 41.22%.&lt;/p&gt;&lt;p class="abstract"&gt;&lt;strong&gt;Conclusions:&lt;/strong&gt; Comparing the efficacy of derma roller therapy and fractional CO&lt;sub&gt;2&lt;/sub&gt;laser resurfacing method in the treatment of post acne scars, both the modalities were found to be equally efficacious.&lt;/p&gt;

Efficacy of autologous platelet-rich plasma combined with microdermabrasion compared with platelet-rich plasma alone on postacne scars

Background Acne is an inflammatory disorder of the pilosebaceous units. The severity of acne scarring depends on delays in treating acne patients. Objective To assess the effect of platelet-rich plasma (PRP) in cases of postacne scar and compare the effect of PRP alone and in combination with microdermabrasion on postacne scars. Patients and methods Twenty adult facial postacne scar patients were enrolled. Goodman and Baron's scale and ECCA scale were used to determine the severity of acne scars. PRP was injected after microdermabrasion on the right side of the face, while PRP was injected alone on the left side of the face. This was done regularly each month for three sessions. Evaluation of improvement was assessed by Goodman and Baron qualitative scale and ECCA scale for each patient both at the baseline and 1 month after the last session, along with photography. Results There was an increase in the scar outcome in the side treated with combined therapy, but it did not reach a significant level between both sides of the face by all objective methods of assessment. Conclusions PRP alone or in combination with microdermabrasion is an effective modality for the treatment of postacne scars.

Curative effect of autologous platelet rich plasma on facial acne scars

Objective To compare the efficacy and safety of two administration modes of autologous platelet-rich plasma (PRP), intradermal injection (ID) and microneedle technique in the treatment of facial post acne scars. Methods From March 2017 to March 2018, 32 patients (8 male, 14 female) with facial acne scars were included. They were randomly divided into two groups (group A and group B) and both underwent splitface therapy. Each group was randomly divided into two subgroups. Group A was administered by microneedle + PRP (A1) on one side and by microneedle + saline (A2) on the other. In group B, one cheek was treated with ID PRP (B1) and the other received ID saline (B2). Each patient received overall 3 treatments per session with 28 days intervals. Patients were followed-up six months after their last treatment and clinical evaluation was assessed by 2 independent plastic surgeons and patients themself. Results The results were obvious difference between each group. The score of evaluation by physicians and patients in A1 group (2.565±0.504) point showed significantly better results compared with other groups. B1 group (1.820±0.592) point was significantly higher than B2 group (1.345±0.483) point (P 0.05). The total effective rate in A1 group was 100%, which was higher than B1 group (43.75%), A2 group (81.25%) and B2 group (25%), with statistical significance (P<0.05). Conclusions The current study introduces the combination of autologous PRP and microneedle technique as an effective and safe modality in the treatment of facial post acne scars with short recovery time and easy operation. Any concerns of immunogenic reactions or disease transfer are eliminated because PRP is prepared from autologous blood. Therefore, the method is suitable to be widely used in clinic. Key words: Platelet-rich plasma; Acne vulgaris; Cicatrix; Atrophy; Microneedle acupuncture therapy

Comparison of Complications that Arise after DT and FCLT in the Treatment of Post-Acne Scars

Background: Acne vulgaris is a common chronic skin disease involving blockage and/or inflammation of pilosebaceous units (hair follicles and their accompanying sebaceous gland). Acne can present - non-inflammatory lesions (open and closed comedones), inflammatory lesions (papules, pustules, and nodules), and varying degrees of scarring or a mixture of both, affecting mostly the face but also the back and chest. Acne leads to significant morbidity that is associated with residual scarring and psychological disturbances such as poor self-image, depression, and anxiety, which leads to a negative impact on quality of life. Subjects and Methods: Total 200 patients divided into two groups of 100 each. One group was treated with dermaroller every four weeks for a period of 24 weeks and the other group was treated with fractional CO2 laser again every four weeks for a period of 24 weeks. Results: Six patients in dermaroller and nine patients in fractional CO2 laser group developed hyperpigmentation post procedure. Conclusion: Itching is not seen as a complication in the treatment with derma-roller, but in case of fractional CO2 laser group, a very small percentage of patients experienced itching a few days after the treatment due to peeling off of the scab that was formed after treatment.

A comparative study of efficacy and safety of platelet rich plasma versus fractional co2 laser in the treatment of post acne scars

&lt;p class="abstract"&gt;&lt;strong&gt;Background:&lt;/strong&gt; Facial scars prompt restorative issues and have mental impacts, for example, humiliation, poor confidence, and social isolation. This study intends to assess efficacy and safety of platelet rich plasma (PRP) versus CO&lt;sub&gt;2&lt;/sub&gt; laser in post acne scar treatment.&lt;/p&gt;&lt;p class="abstract"&gt;&lt;strong&gt;Methods:&lt;/strong&gt; It is an outpatient based comparative study. All patients enlisted in this study were separated into two groups, ten in each treatment group. In group A, patients received PRP month to month for 3 sittings and followed up eight weeks after the third sitting. In group B, patients received fractional CO&lt;sub&gt;2&lt;/sub&gt; laser month to month for 3 sittings and followed up eight weeks after the third sitting. Improvement of acne scars was assessed utilizing digital photographs with identical camera settings and Goodman and Baron’s qualitative grading system at beginning, after each sitting and followed up eight weeks after the third sitting. Patients subjectively evaluated clinical improvement eight weeks after the last sitting. Software (SPSS, version 16.0 statistical packages) was used.&lt;strong&gt;&lt;/strong&gt;&lt;/p&gt;&lt;p class="abstract"&gt;&lt;strong&gt;Results:&lt;/strong&gt; Assessment using qualitative acne scars grading system prior to and after treatment as well as patient’s subjective assessment 2 months after the third treatment session showed significant improvement in both groups. The baseline scores before treatment for group A and B were similar (p=0.7678) and final scores of both treatment groups showed no significant difference (p=0.8011) after treatment.&lt;/p&gt;&lt;p class="abstract"&gt;&lt;strong&gt;Conclusions:&lt;/strong&gt; This study shows that PRP as well as fractional CO&lt;sub&gt;2&lt;/sub&gt; laser result in significant clinical change in the quality of post acne scars.&lt;/p&gt;

Waardenburg syndrome: when the eyes speak the truth

A 30-year-old woman presented to us for the treatment of post acne scars. On examination, she was observed to have broad nasal root and unusually large intercanthal distance (dystopia canthorum,...

Clinical and histopathological evaluation of percutaneous collagen induction (dermaroller) in the treatment of postacne scars

Clinical and histopathological evaluation of percutaneous collagen induction (dermaroller) in the treatment of postacne scars

Commentary on “Comparison of a Fractional Microplasma Radiofrequency Technology and Carbon Dioxide Fractional Laser for the Treatment of Atrophic Acne Scars: A Randomized Split-Face Clinical Study”

I read with interest the article by Zhang and colleagues. The treatment of postacne scars is difficult, as many of us have said over the years. I think we were feeling sorry for ourselves over our inability to have a substantial effect on this seemingly insurmountable problem. We still are unable to reverse scars; we can only make them look less noticeable, maybe not as deep or less colored or more easily covered with make-up.

Hair transplant for acne scars: an innovative approach

Postacne scarring is a common entity that affects patients both physically and psychologically. Treatment of facial scarring is rarely a mono-dimensional process. Various modalities of treatments from cheaper subcision, punch techniques and excision to expensive laser resurfacing techniques are available. Treatment of postacne scars in a particular case has to be individualized, taking into consideration many factors like age, gender, types of scarring, Fitzpatrick skin type, and socioeconomic status of the patient. In this article, we describe an innovative method of simply doing hair transplantation in acne scars and hence making them less visible and cosmetically well acceptable to the patient.