Treatment Of Pneumococcal Infections Research Articles

TREATMENT OF PNEUMONIA IN CHILDREN WITH A SINGLE DOSE OF SULFAPYRIDINE

The effectiveness of sulfapyridine in the treatment of pneumococcic infections has now been accepted generally. There still remains the problem of determining the best method of administration. Since the introduction of sulfapyridine for the treatment of pneumonia in children the recommended duration of treatment has steadily decreased, and the estimates of effective levels in the blood have been revised downward. At present the commonly accepted daily dosage is approximately 0.2 Gm. per kilogram of body weight, in divided doses, and the drug is usually given for from two to four days. A level of 4 mg. of free sulfapyridine per hundred cubic centimeters of blood has been accepted as satisfactory, and favorable therapeutic results have been obtained with levels as low as 2 mg. per hundred cubic centimeters. 1 The experimental work of Long and Feinstone 2 has shown that the excretion of sulfapyridine is slower than that of sulfanilamide.

The Use of Serum, Sulfanilamide, and Sulfapyridine in the Treatment of Pneumococcic Infections

The Use of Serum, Sulfanilamide, and Sulfapyridine in the Treatment of Pneumococcic Infections

Treatment of Pneumococcal Infections in Rabbits with Sulfanilamide

A number of studies have been made to show the curative effect of sulfanilamide in rats, mice, guinea pigs and rabbits, infected with pneumococci by various routes. Because of the difference of opinion concerning the efficacy of the drug in the treatment of infections caused by this microorganism, it was considered timely to investigate further its effects on controlled pneumococcal infection. For this purpose, infection was induced in rabbits by injecting Type I pneu-mococci endermally according to the method of Goodner,1 which permits accurate observations of the fever, bacteremia and of the lesion produced locally.The inoculum consisted of 0.1 cc. of a 1:1000 dilution of an 18-hour blood-broth culture injected endermally in the shaved skin of the abdomen. Rectal temperature was recorded twice daily and blood cultures were made daily until the animal died or recovered. In each of 6 sets of experiments, 4 rabbits were studied; 2 animals were treated and 2 served as controls.For treatment, sulfanilamide (...

The Immunological Types of the Pneumococcus in their Relation to the Prevention and Treatment of Pneumococcal Infections, by D. G. S. MCLACHLAN, M.B., Ch.B., Assistant in the Department of Bacteriology, Edinburgh University

The Immunological Types of the Pneumococcus in their Relation to the Prevention and Treatment of Pneumococcal Infections, by D. G. S. MCLACHLAN, M.B., Ch.B., Assistant in the Department of Bacteriology, Edinburgh University

The Varieties of Pneumococci Causing Lobar Pneumonia, with Especial Reference to Their Biologic Differences

Experimental evidence now at hand indicates that during the course of lobar pneumonia there is a definite biologic reaction characterized by the formation of antipneumococcic substances in the body of the patient. These antibodies are of primary importance in bringing about a favorable termination of the disease. Attempts to utilize this fact in the treatment of pneumococcal infections have led to the important observation that pneumococci vary widely in their serologic reactions.