Despite current advances in minimally invasive surgery, the diagnosis and treatment of liver cysts of non-parasitic genesis remains a controversial issue.
 The aim of the study is to improve the results of surgical treatment of patients with liver cysts of non-parasitic genesis by complex application of mini-invasive diagnostic and surgical methods.
 Materials and methods: patients were carried out clinical, laboratory, instrumental methods of examination, during which liver cysts were identified. Patients were prescribed painkillers before and after puncture to prevent pain syndrome. Puncture was performed under local anesthesia. After the evacuation of the contents, 96 % ethyl alcohol was injected into the cavity. Pig tail 6 F catheters were used for drainage. The average drainage time for liver cysts is (22 ± 1.6) days. Indications were determined for performing the puncture under the control of sonography, laparoscopic method of treatment. Puncture-draining interventions were performed in 53 patients with non-parasitic liver cysts, of which ultrasound-controlled drainage was performed in 30 patients, and video laparoscopic drainage was performed in 23 patients.
 Results and discussion: postoperative period was more favorable in patients who used percutaneous puncture interventions. Immediately after percutaneous interventions under ultrasound control and from the second day after video laparoscopic operations and patients returned to their usual diet and volume of physical activity.
 Conclusions: thus, minimally invasive methods of surgical treatment of non-parasitic liver cysts have significantly improved the rehabilitation of this group of patients.