Introduction: It is standard to observe acute ischemic stroke (AIS) patients under high intensity monitoring (HIM) for the first 24 hours after intravenous thrombolysis (IVT). However, HIM is resource intensive and may not be necessary for every AIS patient. This study evaluates the safety and efficacy of low-intensity monitoring (LIM) for a subset of low-risk AIS patients who received IVT. Methods: Data from patients discharged from 2 hospitals between April 2020-April 2022 admitted to LIM post-IVT were retrospectively abstracted from patient records. Patients under age 18, arrival NIHSS ≥17, presence of large vessel occlusion, need for endovascular therapy, uncontrolled high blood pressure or unstable neuro exam (change in NIHSS of 4 or more within the 1st hour) were excluded. Primary outcomes were transfer back to HIM, instances and treatment of high blood pressure (HBP), in-hospital stroke mortality, discharge disposition and 90-day mRS. Population characteristics of age, sex, race, medical history, transfers to hub prior to LIM admission, discharge mRS and door-to-needle times were also examined. Results: Among 173 patients who met inclusion criteria, 1 (.6%) patient was transferred back to HIM and no patients died from in-patient stroke-related causes. Most patients were discharged home (80.9%) with a median 90-day mRS score of 1 (IQR: 0, 2, Table 1). Conclusion: LIM can reduce resource intensity of stroke care and free up critical care beds, which can result in less cost for the hospital and the patient. We conclude that LIM is safe and effective and could be the standard of care for low-risk AIS patients treated with IVT.