Treatment Of Hiccups Research Articles

A Case of Intractable Hiccup Treated by Acupuncture and Moxibustion

Hiccup is a syndrome characterized by continuous sound in the throat, short and frequent sound, and difficult to stop [1]. Although the disease is not life-threatening, it seriously affects the quality of life of patients. Long term intractable hiccup will also have an impact on the psychology of patients and bring great trouble to patients. Hiccup is equivalent to diaphragmatic spasm in western medicine and involves a variety of systemic diseases [2]. At present, the treatment of this disease includes drugs and nerve block, but the curative effect and prognosis are not ideal. Acupuncture and moxibustion, as a green and simple treatment method, has unique curative effect in the treatment of hiccup. Now the test of one case of intractable hiccup caused by ineffective treatment is as follows.

Acupuncture for hiccups: A systematic review protocol of high-quality randomized trials.

Background:A Hiccup is a common disease that often occurs along with other chronic or acute conditions. At present, there is a lack of feasible therapies for hiccups, and acupuncture is a treatment method with enormous clinical practice worldwide.Methods:Based on a pre-defined search strategy, we searched seven databases and screened them by two independent investigators, without language and publication status restriction from inception to date. We use the pre-set form to incorporate data and utilize Revman software to synthesize data. We will evaluate the risk of bias in the inclusion of the study based on the Cochrane ‘Risk of bias’ assessment tool. The quality of the evidence will be evaluated according to the GRADEpro software.Results:This systematic review will evaluate the efficacy and safety of acupuncture treatment for hiccups. The entire process will be referred to the Cochrane handbook recommended by the Cochrane Collaboration.Conclusion:This review will provide systematic evidence to summarize whether acupuncture is an effective intervention in the treatment of hiccup.

A RARE CASE OF SHINGLES WITH PERSISTENT SINGULTUS AND RESPIRATORY FAILURE

SESSION TITLE: Tuesday Medical Student/Resident Case Report Posters SESSION TYPE: Med Student/Res Case Rep Postr PRESENTED ON: 10/22/2019 01:00 PM - 02:00 PM INTRODUCTION: Herpes zoster, also known as shingles, occurs after reactivation of latent varicella-zoster virus in sensory ganglia. There have been few cases reporting intractable singultus as a complication of shingles; however, none has reported a patient such as ours who presented with intractable hiccups along with hematemesis and acute hypoxic and hypercapneic respiratory failure. CASE PRESENTATION: A 53 year old Caucasian male with a history of Hypertension, GERD, and a recent episode of shingles presented to the ED with a 3 day history of worsening persistent singultus. Five days prior, he developed burning back pain followed by an eruption of a herpetiform rash along the T4-T5 dermatome on the right thorax. He was diagnosed with shingles and started on oral valacyclovir. Two days later, he developed progressively intense paroxysmal hiccup attacks with associated dyspnea and retching that was unresponsive to chlorpromazine. In the ED, he denied URI symptoms, recent travel, neurological deficits, trauma, or recent surgeries. On physical exam, he was afebrile and had a vesicular rash overlying the anteroposterior thorax along the T4-T5 dermatome. He had no electrolyte abnormalities. In the ER, he was started on intravenous acyclovir for herpes zoster; however, the hiccups were refractory to haloperidol, metoclopramide, and lorazepam. After several hours, he became encephalopathic, had hematemesis, and was subsequently intubated and placed on mechanical ventilation for acute hypoxic and hypercapneic respiratory failure. The hiccups terminated when he was sedated. Upon extubation the next day, the singultus resolved. The remainder of the hospital course was uneventful and he was discharged after a couple of days. DISCUSSION: Hiccups represent an involuntary spasmodic contraction of the diaphragm followed by rapid closure of the vocal cords involving the reflex arc and are rarely persistent. Potential causes of persistent singultus include infections, metabolic abnormalities, or structural disorders that irritate the branches of the vagus nerve, phrenic nerve, or the CNS. Treatment of hiccups is aimed at symptomatic relief and addressing the underlying cause. Physical maneuvers such as Valsalva can be initiated as empiric treatment. Pharmacological therapies include chlorpromazine, metoclopramide and muscle relaxants. Persistent hiccups due to Herpes Zoster have only been reported in exceptional few cases. In all previously reported cases, none had persistent hiccups associated with hypoxic and hypercapneic respiratory failure and hematemesis secondary to the retching effect of persistent singultus as a result of herpes zoster as which occurred in our patient. CONCLUSIONS: Physicians should closely monitor the respiratory status of patients who present with persistent singultus in the setting of shingles. Reference #1: Brooks WDW. Zoster, hiccup and varicella. Br Med J 1931;2:298-9 Reference #2: Efrati P. Obstinate hiccup as a prodromal symptom in thoracic herpes zoster. Neurology 1956;601-2 Reference #3: Berlin AL, Muhn CY, Billick RC. Hiccups eructation, and other uncommon prodromal manifestations of herpes zoster. J Am Acad Dermatol 2003;49:1121-4 DISCLOSURES: No relevant relationships by Abilio Arrascaeta Llanes, source=Web Response No relevant relationships by Nikita Cadet, source=Web Response No relevant relationships by Edison Gavilanes, source=Web Response No relevant relationships by Hao kee Ho, source=Web Response No relevant relationships by Princess Mark-Adjeli, source=Web Response No relevant relationships by Zubin Tharayil, source=Web Response

Hiccup after chemotherapy for lung cancer

A 54 years old male patient, 5 months ago, cough and expectoration were induced by lung cancer and hiccups were triggered and lasted for 1 day after radiochemotherapy. Firstly, the sensitized points were detected in the region of BL 17. The disposable subcutaneous trocar acupuncture needle was inserted transversely. Afterward, the Zúsānlĭ (足三里 ST 36) was injected by metoclopramide injection, one mL each point, then catgut embedding was carried at ST36. Comprehensive therapy was used, satisfactory effects can be achieved in the treatment of Hiccup after chemotherapy.

Treatment of Hiccups in Patients With Cancer

Treatment of Hiccups in Patients With Cancer

Clinical effect of acupuncture Yingxiang point in the treatment of 60 patients with hiccups

Objective To observe the clinical effect of acupuncture Yingxiang point in the treatment of hiccups. Methods 120 cases with hiccups were selected, and they were randomly divided into treatment group and control group according to the digital table, 60 cases in each group.The control group was given conventional acupoint acupuncture.The treatment group received acupuncture internal Yingxiang acupuncture point.The total effective rate and effective time of treatment were observed. Results The total effective rate of the treatment group was 100.0%, which of the control group was 96.7%, the difference between the two groups was not statistically significant (P>0.05). The effective time between the two groups had statistically significant difference (χ2=10.75, P=0.00). Conclusion Acupuncture Yingxiang point in the treatment of hiccups can enhance the treatment effect and shorten treatment time. Key words: Acupuncture; lnside yingxiang cave; Hiccups

Challenges in the Diagnosis and Treatment of Hiccup in Neurological Patients

Hiccup is a prevalent event in the general population and can be found from milder, (so-called benign) to persistent and intractable forms. Hiccups have several causes, but stimulation of the phrenic nerve with compression, deformation and traction are among the most prevalent which could be consequence of mediastinal or lung cancer, gastric and/or esophageal distention, gastroesophageal reflux, instruments (catheters and intubation), cholecystitis, pericarditis or neurological causes. The objective of this paper is to stablish one treatment protocol and hiccup treatment in acute, persistent and intractable stages. A literature review was performed at Scielo, Pubmed, Ebsco, Clin Neuropharmacol, and ScienceDirect databases. Articles and publications from 1970 to 2015 were selected. The relevance of this article is the challenge for diagnostic and the difficulty to stablish the best plan to be addressed in cases of persistent or intractable hiccups in neurological patients, since they probably have many causes.

Analysis of factors associated with hiccups based on the Japanese Adverse Drug Event Report database.

Hiccups are occasionally experienced by most individuals. Although hiccups are not life-threatening, they may lead to a decline in quality of life. Previous studies showed that hiccups may occur as an adverse effect of certain medicines during chemotherapy. Furthermore, a male dominance in hiccups has been reported. However, due to the limited number of studies conducted on this phenomenon, debate still surrounds the few factors influencing hiccups. The present study aimed to investigate the influence of medicines and patient characteristics on hiccups using a large-sized adverse drug event report database and, specifically, the Japanese Adverse Drug Event Report (JADER) database. Cases of adverse effects associated with medications were extracted from JADER, and Fisher’s exact test was performed to assess the presence or absence of hiccups for each medication. In a multivariate analysis, we conducted a multiple logistic regression analysis using medication and patient characteristic variables exhibiting significance. We also examined the role of dexamethasone in inducing hiccups during chemotherapy. Medicines associated with hiccups included dexamethasone, levofolinate, fluorouracil, oxaliplatin, carboplatin, and irinotecan. Patient characteristics associated with hiccups included a male gender and greater height. The combination of anti-cancer agent and dexamethasone use was noted in more than 95% of patients in the dexamethasone-use group. Hiccups also occurred in patients in the anti-cancer agent-use group who did not use dexamethasone. Most of the medications that induce hiccups are used in chemotherapy. The results of the present study suggest that it is possible to predict a high risk of hiccups using patient characteristics. We confirmed that dexamethasone was the drug that has the strongest influence on the induction of hiccups. However, the influence of anti-cancer agents on the induction of hiccups cannot be denied. We consider the results of the present study to be helpful for the prevention and treatment of hiccups.

Acupuncture for the treatment of hiccups following stroke: a protocol for a systematic review

Although the positive effects of acupuncture in the treatment of hiccups following a stroke may be seen in actual clinical practice, no systematic reviews exist that describe the use of acupuncture to treat hiccups after stroke. The aim of this study is to analyse the available literature and trial data to determine the efficacy of acupuncture in the treatment of hiccups following stroke. We will search MEDLINE, EMBASE, CENTERAL, CINAHL, and four Chinese medical databases up to June 1, 2015. Randomised controlled trials (RCTs) will be included if acupuncture is assessed as the sole treatment or as an adjunct treatment for alleviating hiccups after stroke. The primary outcome of our analysis is cessation of hiccups within a specified time period following intervention; secondary outcome will include adverse events. Study selection, data extraction, and quality assessment will be conducted by two reviewers. Any disagreement will be resolved through discussion with a third reviewer. The Cochrane risk-of-bias criteria will be used to assess the methodological quality of the trials. The systematic review will be published through a peer-reviewed journal or presented at a relevant conference. We believe that the findings of our review will inform and guide healthcare practice and policy. Trial registration number: PROSPERO CRD42014015481.

Use of Baclofen in the Treatment of Persistent Hiccups: Report of Two Cases

We present two cases of persistent hiccups attributed to lateral medullary syndromes that were refractory to common pharmacological treatment. Introduction of baclofen resulted in the rapid and sustained resolution of hiccups in these patients, with no significant adverse effects noted. Our reports serve to strengthen the limited evidence base for baclofen as a pharmacological agent for treatment of hiccups, and suggest the consideration of its use as a first line treatment specifically in hiccups secondary to lateral medullary infarcts.

Treatment of Hiccup by Vagal Maneuvers

A multitude of nonpharmacological interventions to terminate hiccup belong to the public-domain hiccup “mythology” or have been described in the medical literature as case reports. While usually effective in terminating bouts of acute hiccup, they are mostly ineffective in cases of hiccupping that have been present for an extended period. The common denominator of most of these therapeutic maneuvers (some also used to terminate paroxysmal supraventricular tachycardia) is their ability to directly or indirectly increase efferent vagal activity. Among the best known “vagal maneuvers” are the oculo-cardiac reflex (Dagnini-Aschner), the carotid sinus massage, the Valsalva maneuver, stimulation of the ear/auditory canal, ice ingestion, and induction of emesis. This short report provides an overview on hiccups and attempts to identify the lesser known personalities who pioneered its treatment by vagal maneuvers. The recent introduction of electrical vagus nerve stimulation for therapy-resistant hiccup is the ultimate compliment to these pioneers.

Persistent Hiccups Associated With Switching From Risperidone to Aripiprazole in a Schizophrenic Patient With Cerebral Palsy

Antipsychotics are thought to be effective in the treatment of hiccups; however, they are rarely reported to induce hiccups. We report a case of persistent hiccups after administration of aripiprazole in a patient with concurrence of schizophrenia and cerebral palsy. Prior brain injury and switching antipsychotics may precipitate the development of hiccups in the present case. Aripiprazole with a partial agonist of dopamine D2 receptors and serotonin 1A receptors may play a crucial role in the pathophysiology of hiccups.

Gabapentin in the Treatment of Hiccups in Patients With Advanced Cancer

To evaluate safety and efficacy of gabapentin in the treatment of severe chronic hiccups in patients with advanced cancer. Charts of all patients observed in the palliative care unit of a 4-bed hospital and at home by our Home Care Service were reviewed retrospectively.The presence of hiccups was routinely assessed. Patients with severe chronic hiccups were treated with gabapentin (300 mg t.i.d.). Doses of gabapentin were titrated based on the response to treatment.Gabapentin-related adverse effects were recorded. Thirty-seven (3.9%) of 944 in-hospital patients and 6 (4.5%) of 134 patients observed at home presented severe chronic hiccups.We registered an improvement of hiccups, defined as complete resolution of hiccups, in 31 (83.8%) of 37 in-hospital patients and 4 (66.7%) of 6 patients observed at home.Four (10.8%) of the 37 in-hospital patients and 2 (33.3%) of the 6 patients observed at home experienced a reduction of hiccups.In 2 patients (5.4%), we registered a worsening of hiccups.Responses were observed in 32 patients (74.4%) with gabapentin at a dosage of 900 mg/d and in 9 patients (20.93%) at 1200 mg/d.In 2 patients (4.65%), grade 2 sleepiness was observed and in 10 patients (23.25%), grade 1 sleepiness was observed based on the Epworth Sleepiness Scale. The results of the study allow suggesting gabapentin at least as a promising drug in the treatment of severe chronic hiccups in advanced cancer patients.

Novel Use of Amantadine: To Treat Hiccups

Persistent hiccups may have a considerable impact on general health through disturbance of diet, sleep, and mood. They can cause exhaustion, malnutrition, dehydration, wound dehiscence, and even death in extreme cases. We report a complex clinical case of intractable hiccups in a patient with cancer of the pancreas and Parkinson's disease and some of the problems encountered when attempting symptom control. We also discuss a potential therapeutic response to a novel agent, amantadine, unlicensed in the treatment of hiccups.

Hiccups and dopamine

Lertxundi et al.[1][1] should be commended for reminding readers of the therapeutic complexities in using antidopaminergic agents in Parkinson’s disease (PD). We wish to comment on the etiology and treatment of hiccups. The authors’ statement that anti-dopaminergic therapy is needed for hiccups

Acupuncture Treatment of Hiccup in the Elders

In the treatment of hiccup in the elders by acupuncture plus ear-point embedding method, main acupoints Neiguan (PC 6), Zusanli (ST 36) and Tiantu (CV 22) were treated. Qihai (CV 6) and taixi (KI 3) were added for those with weak constitution due to old age and severe illness, Zanzhu (BL 2) added for those with cerebrovascular disease, and Zhigou (TE 6) added for those with digestive disease and constipation, and Hegu (LI 4) added for those with respiratory disease. Ear-point embedding method on Diaphragm(MA), Stomach(MA), Ershenmen(MA-TF 1), Subcortes(MA-AT 1) and Kidney(MA) were conducted. Results showed cure in 45 cases, improvement in 10 cases and the effective rate was 100%.

Treatment of hiccup caused by cerebral vascular accident by ear acupuncture plus acupuncture: A report of 21 cases

Twenty-one cases of hiccup caused by cerebral vascular accident were treated by synthetically applying auricular acupuncture, acupuncture or cupping therapy, after 3–10 treatment, all the patients were cured.

Treatment of hiccup by finger-pressing Yifeng (TE17): A report of 148 cases

The author treated 148 cases of hiccup by finger-pressing Yifeng (TE 17). After one treatment, 97 cases were cured; 34 cases were cured after 2–3 treatments, 6 cases were cured after over 4 treatments; and 11 cases obtained no effect. The total effective rate was 92.6%.

Treatment of hiccup by acupuncture: A report of 6 cases

Treatment of hiccup by acupuncture: A report of 6 cases

Treatment of hiccup during general anaesthesia or sedation: a qualitative systematic review

Treatment of hiccup during general anaesthesia or sedation: a qualitative systematic review