Treatment Of Animal Diseases Research Articles

English

Knowledge of medicinal plants has accumulated over centuries and often represents the only therapeutic resource of small municipalities in the interior of Brazil. The objective of this study was to evaluate the knowledge and use of medicinal plants by the population of the municipality of Bom Principio do Piaui, Piaui state, for the treatment of diseases in humans and domestic animals. Interviews were conducted with 38 residents using standardized questionnaire forms, with the snowball technique. Fifty nine families, 98 genera and 112 species were recorded. Of these, 22.3% were indicated for the treatment of diseases in animals and 9.8% were said to cause adverse effects. The families with most species were Fabaceae (14), Euphorbiaceae (11) and Lamiaceae (6). The species with greatest use value (UV) were Myracrodruon urundeuva Allemao (0.65), Dysphania ambrosioides (L.) Mosyakin and Clemants (0.63) and Amburana cearensis (Allemao) A.C.Sm. (0.42). The leaves were the parts most frequently used (26.8%), followed by bark (21.0%). Of the 15 used categories listed in this study, those with the highest number of recorded species were related to illnesses associated with the digestive tract (102), diseases of the genitourinary system (72) and diseases of the respiratory system (60). This study revealed the importance of knowledge and use of medicinal plants in caring for the health of people and domestic animals in the municipality. In addition, the study provided information on plants of the local flora with pharmacological potential. Key words: Caatinga, medicinal plant, herbal medicine, popular knowledge.

Observations on traditional usage of ethnomedicinal plants in humans and animals of Kangra and Chamba districts of Himachal Pradesh in North-Western Himalaya, India

Ethnobotanical relevanceMedicinal plants are frequently used by Gaddi and Gujjar tribes of Kangra and Chamba districts of Himachal Pradesh, India to cure various ailments in humans and livestock. Therefore, extensive field work was conducted to document the traditional use of ethnomedicinal plants by these tribes. Materials and methodsDirect interviews of 208 informants were conducted. The data generated through interviews was analysed using quantitative tools such as use-value (UV), factor informant consensus (Fic) and fidelity level (Fl). ResultsA total of 73 plant species in 67 genera and 40 families were observed to be medicinal and used to cure 22 ailment categories. The highest number of ethnomedicinal plants was recorded from the family Asteraceae followed by Lamiaceae, Apiaceae, Acanthaceae, Caesalpiniaceae, Polygonaceae, Ranunculaceae, Rosaceae and Rutaceae. Leaves were the most frequently used plant part used to treat various ailments followed by whole plant and roots or rhizomes. Ajuga parviflora, Berberis lycium, Viola canescens, Vitex negundo and Zanthoxylum armatum were the most important medicinal plants used for treating human diseases, whereas Achyranthes bidentata, Aloe sp., Cassia fistula, Podophyllum hexandrum and Pogostemon benghalensis were the most important medicinal plants used for treating animal diseases as per use value. The important ailment categories classified on the basis of factor informant consensus were gastrointestinal and respiratory disorders. ConclusionThe present study revealed that people of the study area are extensively using the ethnomedicinal plants to cure various ailments. Plants with high use value and fidelity level should be subjected to pharmacological investigation for scientific validation.

Detection of Genotipically Related Multi-resistant Escherichia coli Isolates in Pig Feces and Carcasses

Background: Antimicrobial resistant bacteria are considered a hazard not only for the treatment of animal diseases but also for public health. Commensal bacteria, such as Escherichia coli are considered a good indicator of antimicrobial resistance in the population, because it is a gut inhabitant and thus undergoes constant pressure of selection by the administration of antimicrobials. Regarding the public health, it is important to evaluate if resistant bacteria carried in the intestinal content of slaughter pigs can be found on the surface of pre chill carcasses. Therefore, the aims of this study were to evaluate the frequency of antimicrobial resistance in E. coli isolated from feces and pig carcasses; and to assess if multi-resistant isolates from both sources were phenotypically and genotypically related.Materials, Methods & Results: Two sampling cycles were conducted in three pig slaughterhouses (A, B and C). In each cycle, samples were collected form: i. feces deposited on the pen floor of the lairage; ii. surface of carcasses at the prechill step. Samples were submitted to a protocol of isolation and confirmation of Escherichia coli. Isolates were grouped according to the origin: feces (n = 355); carcasses (n = 319); and evaluated for antimicrobial resistance by agar diffusion test. Ninety two isolates presenting multidrug resistance profile were analyzed by pulsed-field gel eletrophoresis (PFGE). Among the 674 isolates of E. coli, 7.4% were susceptible to all tested antibiotics while 79.5% (536/674) were multi-resistant. The most frequent resistance patterns were displayed to tetracycline (Tet, 85.9%), ampicillin (Amp, 73.0%), sulfonamide (Sul, 70.0%), florfenicol (Flo, 65.0%) and nalidixic acid (Nal, 58.9%). The most frequent multi-resistance profile among isolates from both origins was [AmpFloNalSulTet]. Multiresistant isolates originated from feces and carcasses displaying genotypically related pulsotypes (≥70% similarity) were found in all three slaughterhouses.Discussion: In agreement with other studies, E. coli isolated from pig feces and carcasses demonstrated a high frequency of antimicrobial resistance and multi-resistance. The most frequent resistance profiles included antimicrobials frequently used on farm as well as drugs that have been banned as feed additives some years ago in Brazil. The selection of resistant strains may be related to the selection pressiondue to the use of antimicrobials in the pig production chain as well as the co-selection of resistance mediated by genes located in common genetic elements. Therefore, the ban of an individual drug is not always associated with the immediate disappearance of the resistance phenotype in the bacteria population. The fact that most multi-resistant E. coli isolates from carcasses belonged to pulsotypes related to those originated from feces samples indicates that resistant E. coli isolates selected on farm may be able to survive the slaughter process and be found on the carcass. In this case, the possibility of those strains being able to reach the population through the consumption of pork products may have to be considered. This hazard has motivated the ban of antimicrobial use in animals in some countries. However, the ban of antimicrobials use on farm is a controversial issue, due to the economical losses that may result from this measure. Therefore, the prudent use of antimicrobials on farm should be encouraged and its influence in the multi-resistance profile of the enteric microbiota should be further studied.

β-Cyclodextrin decorated nanocellulose: a smart approach towards the selective fluorimetric determination of danofloxacin in milk samples.

An innovative and versatile strategy of Solid Phase Microextraction (SPME) is shown by using a new type of β-cyclodextrin-modified nanocellulose (CD-NC) as a sorbent material. β-cyclodextrin (used as an inclusion-type selector) was covalently bonded to amine-modified nanocellulose by an amidation reaction. Such novel nanocavities were successfully applied to the selective recognition of danofloxacin (DAN), an antibiotic used to treat animal diseases, via supramolecular host-guest interactions. The SPME methodology, using a platform based on β-cyclodextrin-"decorated" nanocellulose as a sorbent material, showed a wide linear fluorimetric response against DAN from 8 to 800 μg L(-1) and a detection limit of 2.5 μg L(-1). The specific recognition of DAN has been proven to be highly selective and efficient against this metabolite and other fluoroquinolones. The reusability and the high efficiency in the extraction and preconcentration of DAN in milk samples allow recoveries of 94%.

Characterization and in vivo evaluation of nanocapsules loading 99mTc-MIBI for intramammary study

Nanocapsules (NCs) of poly-e-caprolactone (PCL NC) and poly-e-caprolactone coated with chitosan (CS-PCL NC) loaded with technetium-99m methoxyisobutylisonitrile (99mTc-MIBI) were employed as a model to understand the role of these nanocarriers in the veterinary area. 99mTc-MIBI-NCs and 99mTc-MIBI were administrated by intramammary via in rats. The level of radioactivity in the blood was lower when NCs were employed in all times investigated. The results obtained suggest that NCs could be an alternative method for treatment of intramammary diseases in animals, once the data showed high retention in this tissue, increasing the drug residence time on the target.

An ethnobotanical study of medicinal plants used to treat livestock diseases in Onayena and Katima Mulilo, Namibia

Since many small scale and resource-poor livestock farmers cannot afford synthetic pharmaceutical drugs, they turn to indigenous knowledge as an alternative key to unlock the power of ethnoveterinary medicinal plants to treat animal diseases. However, there is no ethnoveterinary pharmacopeia and data on ethnoveterinary usage of plants are still sparse. In this study, an ethnobotanical survey was conducted to document the indigenous knowledge of medicinal plants used to treat livestock diseases in Onayena and Katima Mulilo, Namibia. Using semi-structured interviews and questionnaires, ethnobotanical data were collected from 22 farmers in Onayena, Oshikoto region, and 20 farmers in Katima Mulilo, Zambezi region. The results showed that 16 plant species were used to manage various livestock diseases. Plant leaves were commonly used, being crushed in water, and administered orally or topically. Skin rashes were managed using the plants Aloe esculenta, Salvadora persica, Friesodielsia obovata, and Acanthosicyos naudinianus. Diarrhoea was treated using Ziziphus mucronata, Acacia karroo, and Solanum delangoense. The plants Ximenia americana, Combretum imberbe and Geigeria pectidea were used to relieve eye infections in cattle, goats and sheep. Wounds were treated with Orthanthera jasminiflora, Aloe zebrina and Baphia massaiensis. Livestock owners in Katima Mulilo used water extracts from the roots of Capparis tomentosa to treat the lack of appetite in cattle and goats. In Onayena, Fockea angustifolia roots were used to treat cattle suffering from anthrax. Further studies are needed to determine the minimum inhibitory concentrations, biological activities and toxicities, and to characterize the plants' chemical compounds.

Altered egos: antibiotic effects on food animal microbiomes.

The human food chain begins with upwards of 1,000 species of bacteria that inhabit the intestinal tracts of poultry and livestock. These intestinal denizens are responsible for the health and safety of a major protein source for humans. The use of antibiotics to treat animal diseases was followed by the surprising discovery that antibiotics enhanced food animal growth, and both led to six decades of antibiotic use that has shaped food animal management practices. Perhaps the greatest impact of antibiotic feeding in food animals has been as a selective force in the evolution of their intestinal bacteria, particularly by increasing the prevalence and diversity of antibiotic resistance genes. Future antibiotic use will likely be limited to prudent applications in both human and veterinary medicine. Improved knowledge of antibiotic effects, particularly of growth-promoting antibiotics, will help overcome the challenges of managing animal health and food safety.

Nanotechnology applications in veterinary diagnostics and therapeutics

Livestock is an important component of the economy of most countries of the world, as it provides some foreign exchange earnings for social amenities and general development. Disease has been a major setback in livestock production and new diagnostic and therapeutic approaches have evolved over time to strictly identify and treat diseases of animals for the purpose of increased protein supply for human nutrition. In the search for improved diagnostic methodologies, livestock disease diagnostics and therapeutics have moved from the traditional methods to molecular and currently nanotechnology. In this contribution, the authors identified the importance of nanotechnology in veterinary diagnostics and therapeutics and suggest that nanotechnology should be combined with molecular diagnostics and therapeutics to boost the efficiency in the diagnosis and treatment of animal diseases for improved protein supply and food security.Keywords: Applications, Nanotechnology, Review, Veterinary diagnostics, Veterinary therapeutics

The Differential Effects of Food Safety Regulations on Animal Products Trade: The Case of Crustacean Product Trade

ABSTRACTChloramphenicol is a broad‐spectrum antibiotic that was historically used as a veterinary drug for farm animal disease treatment purposes and it is currently used in human treatment; however, this is a banned substance. This paper investigates the impact of advancing chloramphenicol analytical standards on crustacean imports in the EU15, Japan, and North America. The paper extends the work of Disdier and Marette (2010) by exploring the differential effect of standards on products. We use a Heckman sample selection specification to address zero trade at the product level. We show that submarkets function differently and respond differentially to the standard. Additionally, we show that the level of disaggregation matters in gravity modeling.

Alternatives to antibiotics: a symposium on the challenges and solutions for animal production

Antibiotics are one of the most important medical discoveries of the 20th century and will remain an essential tool for treating animal and human diseases in the 21st century. However, antibiotic resistance among bacterial pathogens and concerns over their extensive use in food animals has garnered global interest in limiting antibiotic use in animal agriculture. Yet, limiting the availability of medical interventions to prevent and control animal diseases on the farm will directly impact global food security and safety as well as animal and human health. Insufficient attention has been given to the scientific breakthroughs and novel technologies that provide alternatives to antibiotics. The objectives of the symposium 'Alternatives to Antibiotics' were to highlight promising research results and novel technologies that could potentially lead to alternatives to conventional antibiotics, and assess challenges associated with their commercialization, and provide actionable strategies to support development of alternative antimicrobials. The symposium focused on the latest scientific breakthroughs and technologies that could provide new options and alternative strategies for preventing and treating diseases of animals. Some of these new technologies have direct applications as medical interventions for human health, but the focus of the symposium was animal production, animal health and food safety during food-animal production. Five subject areas were explored in detail through scientific presentations and expert panel discussions, including: (1) alternatives to antibiotics, lessons from nature; (2) immune modulation approaches to enhance disease resistance and to treat animal diseases; (3) gut microbiome and immune development, health and diseases; (4) alternatives to antibiotics for animal production; and (5) regulatory pathways to enable the licensure of alternatives to antibiotics.

In vivo investigation of ceftiofur-loaded gelatin and PLGA microspheres in beagle dogs

Drug delivery systems based on polymer microspheres have received considerable attention. Ceftiofur sodium and ceftiofur hydrochloride is widely used for the treatment of bacterial diseases in animals but the delivery in vivo has not been reported. In this paper, we report the synthesis of microspheres from gelatin and PLGA, two kinds of typical natural and artificial materials, for loading ceftiofur and the in vivo investigation of the pharmacokinetics in beagle dogs. By controlling the synthesis parameters, gelatin and PLGA microspheres with diameter between 5 and 35 microns were obtained. Assay procedures based on high performance liquid chromatography were evaluated and confirmed. The dogs were randomly divided into three groups, i.e., control group, gelatin group, and PLGA group and administrated via intravenous injection. Plasma concentrations of ceftiofur over time were measured and analyzed. Results indicate that the main kinetic parameters do not show significant difference for the gelatin group and control group, but the area under the curve, plasma half-life, apparent volume of distribution, and clearance ratio of PLGA group show significant difference from the gelatin group and the control group. The PLGA microspheres show a low area under the curve but long time release.

Ethnoveterinary knowledge and practices at Colares island, Pará state, eastern Amazon, Brazil

Ethnopharmacological relevanceThe lack of ethnoveterinary surveys in Brazil, especially in the Amazon region, results in losses in the veterinary phytopharmacology field and in scientific documentation of the cultural traditions of plant use in the treatment of animal diseases. Aim of the studyTo catalog, analyze and disseminate the ethnoveterinary knowledge of the inhabitants of Colares Island, Pará state, eastern Amazon, Brazil. Materials and methodsA total of 72 interviews were conducted, and semi-structured questionnaires were answered by 18 men and 54 women. The data obtained were quantitatively analyzed using the informant consensus factor (ICF) and use value (UV). The plants with a reported medicinal use for domestic animals were harvested, herbalized and botanically identified. ResultsFifty-six plants, distributed in 49 genera and 35 families, were indicated to have 23 different medicinal uses, divided into six categories of use. The highest ICF (0.80) was obtained for the antiparasitic class. The Euphorbiaceae family exhibited the highest number of citations, and the species with the highest UVs were Caladium cf. bicolor, Bixa orellana, Carapa guianensis, Jatropha curcas and Cymbopogon citratus. The parts of the 56 plants that were most frequently used to prepare ethnoveterinary medications were the leaves (46%), bark (15%), roots and fruit (10%). The use of the macerated leaves was the most common method of application, used by 43% of the interviewees, and the majority of the preparations (87.3%) used a single plant. In addition to medicinal plants, the interviewees reported the use of products of animal and mineral origin. ConclusionThe present study contributed to the establishment of an inventory of plants used in ethnoveterinary practices in this region of the Brazilian eastern Amazon. Future phytochemical and pharmacological studies are needed to confirm the efficacy and safety of the identified plants, enabling communities to use them in a more economic, effective and safe manner.

Effect of inoculation route on the production of antibodies and histological characteristics of the spleen in laying hens

Recent studies have reported the use of IgY antibody in the prevention or treatment of diseases in animals. IgY can be obtained in large amounts from the yolk of chicken eggs through a low-cost process. This study evaluated the effect of different routes of inoculation on antibody production and spleen morphological characteristics of laying hens (White Leghorn) inoculated with sheep red blood cells. The analysis of the results showed that the intramuscular route is the most efficient for total antibody production in the primary immune response, while the intravenous route is the most efficient in producing IgY antibodies in the secondary immune response. No histological changes were observed in the spleen of laying hens. This study could be useful for developing protocols of antigen inoculation in laying hens for IgY antibody production.

Prevalence and Mechanism of Antimicrobial Resistance in Staphylococcus aureus Isolates from Diseased Cattle, Swine and Chickens in Japan

Antimicrobial administration is essential for the control and treatment of diseases in animals, but the emergence and prevalence of antimicrobial-resistant Staphylococcus aureus is a significant concern during animal production. Here we investigated the antimicrobial susceptibility of S. aureus from diseased food-producing animals and molecularly characterized the methicillin-resistant and fluoroquinolone-resistant isolates. A total of 290 S. aureus isolates obtained from cattle (n=246), swine (n=16), and chickens (n=28) between 2003 and 2009 were examined for antimicrobial susceptibility against 9 antimicrobials using an agar dilution method. Resistance to penicillin (PC) was most frequently found (24.8%), followed by oxytetracycline (OTC, 10.0%), dihydrostreptomycin (4.1%), erythromycin (EM, 3.1%), enrofloxacin (ERFX, 2.1%), and kanamycin (1.7%). The PC resistance rate was significantly higher in swine than in cattle (P<0.01) and chickens (P<0.01). The resistance rates to OTC, EM and ERFX were significantly higher in swine and chickens than in cattle (P<0.05). Methicillin-resistant S. aureus (MRSA) was recovered from milk derived from a cow with mastitis in 2003; sequence type 8, SCCmec type IV and spa type t024. In the six ERFX-resistant strains isolated after 2003, amino acid substitutions in ParC with/without GyrA were detected. As the prevalence of MRSA and FQ-resistant S. aureus in the animals should be noticed, continuous monitoring is necessary to control resistance to clinically important antimicrobials in S. aureus from food-producing animals.

Chemiluminescence enzyme immunoassay for the determination of sulfamethoxydiazine

Sulfamethoxydiazine (SMD), which is often used for animal disease treatment, is harmful to human health. No SMD residue should be detected in food in some countries, such as USA and Japan. Therefore, it is significant to develop a high-throughput, high-sensitivity and accurate method for the determination of the content of SMD in food. In this paper, chemiluminescence enzyme immunoassay (CLEIA) was developed for quantification of SMD. For this method, the limit of detection was 3.2 pg/ml, the linear range was from 10 to 2000 pg/ml, the within-day and inter-day precision were below 13% and below 18%, respectively, and the recovery was from 85% to 105%. Milk and egg were selected as samples to be examined with this method, and the result indicated that this CLEIA method was suitable for screening and quality control of food.

Veterinary Pharmacy, a Dismissed Necessity

Veterinary pharmaceuticals play an important role in human and animal health. Although some dosage forms are specially designed for use in animals (e.g. ear tags, collars and darts), most drug delivery systems (including nano-carriers and controlled drug delivery systems) are common between animals and human (1). A successful drug development process (for human or animal use), from initial drug discovery to market, requires skill and knowledge in different areas of science of which some disciplines (e.g. pharmaceutics) are exclusively covered in pharmacy undergraduate or postgraduate programs. Pharmaceutics is the art, science and technology of drug delivery system design, manufacture and control and include pre-formulation studies, dosage form design, pharmaceutical processing, quality control, quality assurance, biopharmaceutics and etc. Therefore, like human medicine, pharmacists are expected to design, manufacture and control veterinary drug delivery systems at both levels of pharmaceutical companies or compounding in a pharmacy. This is not what is happening in most veterinary pharmaceutical companies and almost all veterinary-based pharmacies in here, where the professions are performed by veterinary medical doctors (Doctor of Veterinary Medicine, DVM) (2). The educational program in veterinary medicine (DVM) is clinical-based and is focused on prevention, diagnosis and treatment of animal diseases (3), the same perspective as that designed for the physicians (MD). While, there is not such authorization for physicians to act the same in humanoriented pharmaceutical systems. On the other hand, formulation of many drugs for human use is seldom suited for animal administration (4). Design and preparation of veterinary drug delivery systems requires different considerations and is facing more challenges than that of human formulations and cannot be implemented based on human data only. Following are some special considerations (1, 5):

Ethnoveterinary plant remedies used by Nu people in NW Yunnan of China

BackgroundNu people are the least populous ethnic group in Yunnan Province of China and most are distributed in Gongshan County, NW Yunnan. Animal production plays an important role in Nu livelihoods and the Nu people have abundant traditional knowledge of animal management and ethnoveterinary practices. This study documents the animal diseases, ethnoveterinary plant remedies and related traditional knowledge in three Nu villages of Gongshan County.MethodsThis study was carried out in three Nu villages of Gongshan County between July 2009 and February 2010. Data was obtained through the use of semi-structured questionnaires, field observation and PRA tools. A total of 60 Nu respondents (34 men and 26 women) provided information on animal ailments and ethnoveterinary plant medicines used for Nu livestock production. Information on traditional ethnoveterinary medicine knowledge and choice of treatment providers was also obtained.ResultsThirty-five animal conditions were identified in the surveyed area. The major and most common animal diseases among livestock were skin conditions, diarrhea, heat, fevers, colds, and parasites. Most ailments occurred between June and August. The ethnoveterinary medicinal use of 45 plant species was documented. Most medicinal species (86.7%) were collected from the wild. The most frequently used plant parts were whole plants (35.6%), followed by roots (22.2%). The most important medicinal plant species were Saussurea costus (Falc.) Lipech. (UV = 0.67), Senecio scandens Buch.-Ham.ex D.Don (UV = 0.67), Plantago depressa Willd. (UV = 0.63), Rubus corchorifolius L. f. (UV = 0.62), Bupleurum yunnanense Franch. (UV = 0.60), and Polygonum paleaceum Wall. (UV = 0.60). Animal diseases treated with the highest number of ethnoveterinary plant remedies were diarrhea (16 plant species), heat, fever, colds (11 plant species), retained afterbirth (11 plant species), and skin conditions and sores (11 plant species). Many Nu villagers (52%) considered traditional remedies their first choice of animal disease treatment. Traditional ethnoveterinary knowledge was related to the local social-cultural characteristics of Nu people and communities.ConclusionAnimal production plays an important role in Nu culture and livelihoods, and the Nu ethnic group has abundant traditional knowledge about animal production and ethnoveterinary plant remedies. This traditional knowledge faces the risk of disappearing due to increasing modern veterinary medicine extension, livelihood changes and environment degradation. Animal diseases are a major constraint in livestock production in Nu villages. Thus, some strategies and measures should be adopted in the future, such as further researches on Nu culture and livelihoods, community-based validation of ethnoveterinary medicine and broad network building and knowledge sharing.

ChemInform Abstract: In vitro Microbiological Characterization of Novel Cyclic Homopentapeptides, CP-101,680 and CP-163,234, for Animal Health Use.

Two cyclic homopentapeptides, CP-101,680 and CP-163,234 [6a-(3',4'-dichlorophenylamino) analogs of viomycin and capreomycin, respectively], were identified as novel antibacterial agents for the treatment of animal disease, especially for livestock respiratory disease. The in vitro microbiological characterization of both CP-101,680 and CP-163,234 was carried out using their parent compounds, viomycin and capreomycin, as controls. This characterization included antibacterial spectrum, influence of media, inoculum size, pH, EDTA, polymixin B nonapeptide (PMBN), serum, cell-free protein synthesis inhibition, and time-kill kinetics. Our results indicated that the capreomycin analog, CP-163,234, showed slightly improved in vitro potency over the viomycin analog, CP-101,680. Both analogs showed very potent cell-free protein synthesis inhibition activity and were bactericidal against Pasteurella haemolytica, P. multocida and Actinobacillus pleuropneumoniae at the level of 4 times and 8 times MICs. CP-163,234 was bactericidal at the level of 4x and 8x MIC against E. coli, but re-growth was observed after 24 hours incubation at both concentrations of CP-101,680.

Fluoroquinolone Resistance in Campylobacter

Campylobacter is a commensal in poultry, and therefore, poultry and poultry products are major sources of Campylobacter infections in humans. Fluoroquinolones inhibit the growth of Campylobacter and other microorganisms by binding to bacterial DNA gyrase and DNA topoisomerase IV. These enzymes are associated with bacterial transcription, replication, and chromosome condensation and segregation. Selection pressure in the presence of fluoroquinolones rapidly leads to resistance in Campylobacter, due to the selection for mutations in DNA gyrase. Fluoroquinolone-resistant campylobacters have been found in poultry feces and carcasses, and in retail poultry meat products in most areas of the world. In addition, other food animals and the meat products from those animals have been shown contaminated with fluoroquinolone-resistant campylobacters. Even the removal of fluoroquinolones from use in treating animal diseases has not entirely eliminated the presence of resistant Campylobacter jejuni and Campylobacter coli from animals and animal products. Human exposure to Campylobacter infection could be reduced by using strategies that decrease colonization of chickens by the pathogen.

Animals to heal animals: ethnoveterinary practices in semiarid region, northeastern Brazil.

BackgroundAnimal-based remedies constitute an integral part of Traditional Medicine and this is true in Brazil as well both in rural and urban areas of the country. Due to its long history, zootherapy has in fact become an integral part of folk medicine in the country. The use of these natural resources for medical purposes, however, is not restricted to human diseases treatment, being also widely used for the treatment of animal illnesses. Ethnoveterinary is a science that involves the popular practical knowledge used to treat and prevent animal diseases. This study documents ethnoveterinary practices in one local semi-arid region in Northeast Brazil and discusses the findings in the surveyed area.MethodsInformation was obtained through the use of semi-structured questionnaires. A total of 20 respondents (09 men and 11 women) provided information on animal species and body parts used as medicine, information concerning the illnesses to which the remedies were prescribed were also obtained.Results and conclusionEleven animal species were used in the treatment of 11 diseases in the surveyed area. The species inventoried comprise 3 taxonomic categories: mammals (05), reptiles (04) and birds (02). The obtained results proves that the use of animals or their derived products as therapeutic resources to the treatment of animal diseases represent a common practice and is culturally important in the studied area. It is evident that the popular knowledge about the ethnoveterinary practices is, frequently, passed through generations. We also noticed that, besides the cultural aspects, the socio-economic context permeates the use of zootherapics, since these practices constitute an alternative to the medicines acquired in veterinarian pharmacies, which have a high cost.