A study was undertaken to evaluate the efficacy of a number of different therapeutic regimens in the treatment of denture stomatitis. The therapeutic agents employed included 2 per cent amphotericin B in an adhesive base, a denture adhesive, a diluted sodium hypochlorite solution as a soaking medium, and 0.1 per cent triamcinolone acetonide in an adhesive base. Various of these regimens of drug therapy were found to be useful, where indicated, as adjunctive aids in the management of denture stomatitis. However, the administration of drug therapy is not intended to replace or supersede complete and thorough prosthetic dental care for patients with denture stomatitis. A thorough examination of the mouth as well as a complete evaluation of the dentures is a necessary prerequisite to any anticipated therapy. Laboratory procedures to ascertain the presence or absence of C. albicans organisms must also be considered essential in most instances of denture stomatitis. Finally, no single, specific drug therapy, arbitrarily selected, should be relied upon.