Treatment Of Craniocerebral Injury Research Articles

Co administration of oxiracetam and monosialotetrahexosylganglioside for the treatment of patients with craniocerebral injury, and their effect on serum S100 proteins and neuron specific enolase

Purpose: To determine the efficacy of oxiracetam plus monosialotetrahexosylganglioside (GM1) in the treatment of craniocerebral injury, and its effect on serum S100 proteins and neuron-specific enolase (NSE).
 Methods: A total of eighty patients with severe craniocerebral injury admitted to Shengli Oilfield Central Hospital between January 2020 and December 2021 were selected for the study, and assigned 1:1 to control group (GM1 only, 2 mL daily through intravenous drip) and study group (GM1, 2 mL daily through intravenous drip, in combination with oxiracetam, and 4 g dissolved in 100ml of saline daily through intravenous drip). The treatment duration was two months.
 Results: Baseline patient characteristics were comparable between the two groups (p > 0.05). GM1 plus oxiracetam produced better restoration of cranial functions of patients after craniocerebral injury when compared with GM1 alone, as evidenced by the significantly lower S100 proteins and NSE levels of the study group than the corresponding parameters of the control group after 1, 2, 3, and 7 days of treatment (p < 0.05). More significant mitigation of inflammatory reactions was observed in patients co-administered GM1 and oxiracetam than in those who received GM1 only, as shown by the lower serum concentrations of inflammatory factors {(c-reactive protein (CRP), tumor necrosis factor α (TNF-α), interleukin-6 (IL-6), and neuropeptide Y (NPY)} in the study group as compared with the control group (p < 0.05). A few patients experienced minor adverse reactions such as gastrointestinal discomfort, nausea and vomiting, dizziness and headache, and rash during treatment (p > 0.05).
 Conclusion: Co-administration of oxiracetam and GM1 is a viable strategy for the treatment of patients with craniocerebral injury, as it significantly lowers the levels of serum S100 proteins and NSE, mitigates inflammatory reactions, and ameliorates cerebral hemodynamics in patients. The combined therapy also has a good safety profile.

Observation of Clinical Application of Meningeal Patch Combined with Large Bone Flap Decompression in the Treatment of Craniocerebral Injury

Observation of Clinical Application of Meningeal Patch Combined with Large Bone Flap Decompression in the Treatment of Craniocerebral Injury

The efficacy of mild hypothermia combined with edaravone in the treatment of craniocerebral injury：A meta-analysis

The purpose of this meta-analysis was to evaluate the efficacy of mild hypothermia combined with edaravone in the treatment of craniocerebral injury. Methods: Databases, including Cochrane Library, PubMed, Embase, Medline, WebofScience, CNKI, VIP, and Wanfang Database were searched from the dateof their establishmentto October 2021, toaccessclinical randomized controlled trials(RCTs) of mild hypothermia combined with edaravonefor craniocerebral injury.Ameta-analysis was then conducted byusing RevMan 5.4.1software programs.Results:A total of 14 RCTs including 1166 patients were included. The results of the metaanalysis were as followed, combination group compared with the control group, can reduce the degree of brain edema [RR=1.94,95%CI=(1.59, 2.36)] and improve the recovery of patients with craniocerebral injury from coma [MD=-0.74,95%CI=(-0.81,-0.67)].Effectively reduce the degree of postoperative neurologic deficits [MD = 4.41, 95% CI = (3.65, 5.18)], patient quality of life improved after discharge [MD = 0.74, 95% CI = (0.81, 0.67)].Conclusion:Mild hypothermia combined with edaravonehas efficacy in the treatment of the craniocerebral injury.It helps to reduce the degree of brain edema and improve the prognosis of patients with craniocerebral injuries.

Exploration of the Therapeutic Strategy of Hyperbaric Oxygen in the Treatment of Craniocerebral Injury in Children

Exploration of the Therapeutic Strategy of Hyperbaric Oxygen in the Treatment of Craniocerebral Injury in Children

Tabu search algorithm analysis on effect of Xingnaojing Injection in treatment of craniocerebral injury and complications in real world

In this study, Tabu search algorithm was used to analyze the drug combination of Xingnaojing Injection in the treatment of brain injury and complications in the real world, and the clinical drug combination of Xingnaojing Injection in the treatment of brain injury and complications was selected and summarized. The combination of Xingnaojing Injection, Namefen and Citicoline were recommended in the treatment of brain injury and complications. For brain edema and nerve injury, Mannitol/Glycerol Fructose/Furosemide+Tetrahexose Monosialate Ganglioside Sodium should be recommended. For those with pulmonary infection, Xingnaojing Injection+Xiyanping+Ambroxol Hydrochloride+Tanreqing Injection should be recommended. For those with shock, Hydroxyethyl Starch+Dopamine Hydrochloride/Dobutamine Hydrochloride+Sodium Bicarbonate should be recommended. The combination reflected the characteristics of Chinese and Western medicine. The above medication regimen was only for clinicians' reference. The clinical application should be based on patients' specific conditions, clinical benefits and risks, as well as the incompatibility. On the basis of the findings, further studies can be carried out for prospective clinical efficacy evaluation and safety evaluation for a specific subgroup module.

ПІДСИСТЕМА ДІАГНОСТУВАННЯ РОБОТИ КАНАЛІВ ВИМІРЮВАННЯ ПРИСТРОЮ ДИФУЗНОЇ ОПТИЧНОЇ ТОМОГРАФІЇ ВИСОКОЇ ЩІЛЬНОСТІ

Одним із сучасних підходів до діагностування різного типу захворювань в медицинській практиці є використання пристроїв дифузної оптичної томографії високої щільності, особливо це є актуальним в тих місцях, де не завжди є можливість доступу до традиційного томографічного обладнання, такого як комп'ютерна чи магнітно-резонансна томографія. У роботі розглянуто основні підходи до побудови інформаційної підсистеми діагностування роботи оптичних каналів під час вимірювань в режимі реального часу, що дає змогу оперативно реагувати на виявлені артефакти в отримуваному сигналі та приймати рішення щодо їх усунення.

颅脑损伤合并颅内动脉瘤破裂诊断及手术治疗—病例报告

颅脑损伤合并颅内动脉瘤破裂诊断及手术治疗—病例报告

Treatment of Craniocerebral Injuries

NEWSPAPERS daily accent the magnitude of the problem of craniocerebral trauma. In the twenty years from 1934 to 1954 more than 700,000 persons were killed in automobile crashes. In 1953 deaths from poliomyelitis numbered less than 2000, whereas automobile fatalities numbered some 38,000.1 By a conservative estimate 50 to 70 per cent of these deaths were from head injury.It is the purpose of this paper to present the problem of craniocerebral trauma in broad perspective. It is hoped that this will afford a frame of reference in which progress in treatment may be considered. Of necessity, many areas will . . .

Essential Don’ts in the Treatment of Craniocerebral Injuries

Essential Don’ts in the Treatment of Craniocerebral Injuries

The Treatment of Craniocerebral Injuries

The Treatment of Craniocerebral Injuries

The use of cholinergic blocking agents in the treatment of cranio-cerebral injuries.

The use of cholinergic blocking agents in the treatment of cranio-cerebral injuries.

NEW YORK NEUROLOGICAL SOCIETY AND NEW YORK ACADEMY OF MEDICINE, SECTION OF NEUROLOGY AND PSYCHIATRY

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Physiology, Pathology, and Treatment of Craniocerebral Injuries

Physiology, Pathology, and Treatment of Craniocerebral Injuries