The efficacy of mild hypothermia combined with edaravone in the treatment of craniocerebral injury：A meta-analysis

Abstract

The purpose of this meta-analysis was to evaluate the efficacy of mild hypothermia combined with edaravone in the treatment of craniocerebral injury. Methods: Databases, including Cochrane Library, PubMed, Embase, Medline, WebofScience, CNKI, VIP, and Wanfang Database were searched from the dateof their establishmentto October 2021, toaccessclinical randomized controlled trials(RCTs) of mild hypothermia combined with edaravonefor craniocerebral injury.Ameta-analysis was then conducted byusing RevMan 5.4.1software programs.Results:A total of 14 RCTs including 1166 patients were included. The results of the metaanalysis were as followed, combination group compared with the control group, can reduce the degree of brain edema [RR=1.94,95%CI=(1.59, 2.36)] and improve the recovery of patients with craniocerebral injury from coma [MD=-0.74,95%CI=(-0.81,-0.67)].Effectively reduce the degree of postoperative neurologic deficits [MD = 4.41, 95% CI = (3.65, 5.18)], patient quality of life improved after discharge [MD = 0.74, 95% CI = (0.81, 0.67)].Conclusion:Mild hypothermia combined with edaravonehas efficacy in the treatment of the craniocerebral injury.It helps to reduce the degree of brain edema and improve the prognosis of patients with craniocerebral injuries.