Meeting Abstracts1 May 1971Results of Treatment of Chronic Active Hepatitis with Azathioprine and Prednisone.Eugene I. Winkelman, M.D., F.A.C.P., Charles H. Brown, M.D., F.A.C.P., Edgar Achkar, M.D.Eugene I. Winkelman, M.D., F.A.C.P.Search for more papers by this author, Charles H. Brown, M.D., F.A.C.P.Search for more papers by this author, Edgar Achkar, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-74-5-835_4 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptChronic active hepatitis is defined as active fiver disease persistent or intermittent for more than 3 months and characterized by high levels of serum transaminase; hypergammaglobulinemia; the presence of serum autoantibodies; and histological changes of "piece-meal necrosis," hepatocellular necrosis, and lymphocytic infiltration with various degrees of fibrosis.The clinical courses (4 months to 4 years) of 18 patients with chronic active hepatitis treated with azathioprine and prednisone are reported. The median age was 22 (15 to 62 years), and 14 patients were women. Fifteen patients had pretreatment biopsies. Initial treatment was 100 mg of azathioprine combined with 20 to 40... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Cleveland, Ohio. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1971Volume 74, Issue 5Page: 835-835KeywordsAminotransferasesAutoantibodiesBiopsyChronic hepatitisFibrosisHepatitisHypergammaglobulinemiaNecrosis Issue Published: 1 May 1971 PDF DownloadLoading ...