Introduction: Approximately 84% of patients have an acute deterioration within 8 to 48 hours of cardiac arrest, most often manifested as hypotension or tachypnea. Accordingly, the Institute for Healthcare Improvement recommends implementation of rapid response teams as a part of their 100,000 Lives Campaign to reduce preventable hospital deaths. Currently at Froedtert Hospital, ACLS trained pharmacists respond to medical emergencies 24/7, but do not have a formal role on the rapid response team (RRT). Prior studies investigating pharmacist presence only evaluated interventions and team perceptions, but have not evaluate outcomes. Methods: This was a retrospective, pre-post interventional study that evaluated 161 patients before and 175 patients after pharmacist implementation on a rapid response team. Patients who were admitted as inpatients between August and October 2012 or between March and May 2013 were included in either the pre-interventional or pilot arm, respectively. Patients were excluded if they were an outpatient, a visitor, a clinic patient, an intensive care unit or emergency department patient or had a rapid response that progressed immediately into a medical emergency. The primary outcome was turnaround time for medication administration, with a goal turnaround time of less than 30 minutes. Pertinent descriptive secondary outcomes consisted of the most frequently administered medications, the indications for RRT, and the number of rapid responses that result in subsequent ICU admission and medical emergencies. RRT calls within 24 hours of admission or 48 hours of ICU discharge, total and post RRT call hospital length of stay, survival to hospital discharge, and pharmacist interventions on the RRT were also evaluated. Results: The addition of a pharmacist decreased medication turnaround time (mean = 45 min +/- 5 vs. 3 min +/- 4; median = 31 vs. 28 min, p = 0.278) and trended towards more patients with an acceptable turnaround time of under 30 minutes (49.1% vs. 57.1%, p = 0.155). The most frequently administered classes of medications were for the acute treatment of atrial fibrillation (22.1% vs. 15.1%), acute treatment of seizures (5.3% vs. 9.2%), analgesics (8.4% vs. 5.9%), antibiotics (8.4% vs. 12.6 %), reversal agents (14.7% vs. 17.6%), and other medications (41.1% vs. 39.5%, p = 0.52). No other variables were different between the two groups besides number of medication changes post-RRT, which were greater in the pre-interventional arm (43.4% vs. 56.1%, p = 0.002). Pharmacists documented on only 90/162 patients (55.5%), while 18/90 patients (20%) had documented a pharmacist intervention on dosing, preparing emergent medications, and drug/patient information. Conclusions: The addition of a pharmacist to a rapid response team reduced time to medication administration and helped improve the medication use process by identifying areas for improvement.