Treatment Of Acid-peptic Diseases Research Articles

Pharmacology and clinical use of antacids

The pharmacology of antacids, with particular reference to their clinical use in treating acid-peptic disease, is discussed. Liquid antacid suspension should be given at least as often as one hour after each meal and at bedtime. Inthe treatment of the acute phase of acid-peptic disease, hourly antacid is recommended. The dose should be planned in terms of milliequivalents of acid neutralizing capacity and should be adjusted according to the type of disease under treatment. All antacids have side effects, the most serious of which are metabolic. In clinical terms, the harmful sustemicside effects of calcium carbonate and sodium bicarbonate outweigh their benefit as neutralizing agents; they should rarely be employed in the treatment of acid-peptic disease. The more common antacid side effects of diarrhea (magnesium hydroxide) and constipation (aluminum hydroxide) are best managed by appropriately alternating the agents or by using one of the various antacid mixtures.

Trends in Anesthesia for Surgical Treatment of Acid Peptic Disease

Anesthesia for patients undergoing surgery for acid-peptic disease is of considerable interest to both the surgeon and the anesthesiologist; adequate exposure of the upper abdomen involves not only impairment of ventilation and hemodynamic alterations, but also a need for profound muscle relaxation and prevention or management of certain reflex activity. Preanesthetic evaluation, anesthetic management, and immediate postoperative care of the patient.