To meet the requirements of domestic solid waste treatment and technological upgrading of bioreactors, a spatiotemporally anaerobic/semi-aerobic bioreactor (STASAB) was designed. The STASAB took full advantages of anaerobic and semi-aerobic bioreactors by the sequential alternation of anaerobic and semi-aerobic operation and by recirculation of mixed leachate from different-stage bioreactors. Results indicated that after the start-up stage, the pH of leachate in the STASAB always remained higher than 6.88, even in the hydrolysis and acidogenesis stage. The maximum total nitrogen concentration in the STASAB was 1461 mg·L−1, which was merely half that of the sequentially anaerobic/semi-aerobic bioreactor (SASAB) and had no adverse effects on the anaerobic process. Nitrogen removal in the STASAB reached 92.3%–95.5% when operated in the semi-aerobic phase and even reached 49.4% when operated in the anaerobic phase. The peak concentration of chemical oxygen demand was much lower and the anaerobic digestion lag time was much shorter in the STASAB than in the SASAB. The period of rapid biogas production in the STASAB was double that of the SASAB, which resulted in a 70% increase in biogas generation. Moreover, leachate could be exhausted by evaporation in just 3–5 months during the semi-aerobic phase. Therefore, the STASAB can eliminate acidogenic and ammonia inhibition during solid waste treatment, enhance the rate and extent of organic waste decomposition, rapidly initiate methanogenesis, enhance methane generation, and achieve zero leachate discharge (excluding rainfall infiltration). The STASAB is an efficient and feasible technique for treating domestic solid waste in rural areas.
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