Treatment Of Ranula Research Articles

Homoeopathic Therapeutics in treatment of Ranula

Ranula is one of the rarest mucoceles that occurs on the mylohyoid muscle through the floor of the mouth present at the anterior two-thirds and typically comprise the primary salivary glands. Ranula arises ducts of the sublingual gland's Rivinus, which are located in the body of the sublingual gland, and exceptionally from the small salivary glands. This article deals with information about Ranula and its homoeopathic medicines that has great role in managing the swelling and terminating the Ranula and also helps in breaking the tendency of recurrences.

OK-432 Treatment of Ranula Intruding into the Cervical Region.

Objectives: Plunging ranula intruding into the cervical region is rare and a standard therapy has not yet been consolidated. This paper investigates the outcomes and side effects of OK-432 treatment in patients with a ranula extending into the cervical region. Methods: The study design and setting consisted of a planned data collection at Tohoku Medical and Pharmaceutical University and Fukase Clinic. Eight patients with ranula extending into the cervical region received OK-432 treatment between January 2016 and February 2019. OK-432 treatment was performed for patients with ranula extending into the cervical region. Results: In all patients, a total shrinkage and marked reduction in lesions were observed without local scars or deformations after OK-432 treatment. Complications were local swelling and mild fever (37.5–38.5 °C), which lasted a few days in half of the patients. Conclusions: OK-432 treatment is straightforward, secure, and efficacious and can be substituted for surgery in the treatment of ranula extending into the cervical region.

Bleomycin sclerotherapy following doxycycline lavage in the treatment of ranulas: A retrospective analysis and review of the literature.

A ranula is a mucus-filled salivary pseudocyst that forms in the floor of the mouth, commonly arising from the sublingual or submandibular salivary glands following obstruction or trauma. Complete excision of the injured gland and removal of the cyst content is the first-choice therapy, but has the potential for complications related to injury to nearby structures. As such, minimally invasive approaches such as percutaneous sclerotherapy have been investigated. We aim to contribute to the literature by assessing the efficacy and safety of our technique through our experience with 18 patients over the last decade. This retrospective study evaluated 18 patients with intraoral and plunging ranulas treated by percutaneous bleomycin ablation. The primary endpoint was the treatment result. Secondary endpoints included bleomycin dosage and complications. The study evaluated 12 males and six females with a median age of 23.5 years (range 13-39 years). At a final follow-up of at least 2 months (6.5±5.5 months), four patients demonstrated complete response (22%) and 14 patients demonstrated residual presence, recurrence, or regrowth of the lesion (78%). There were no statistically significant associations between outcomes and history of prior treatment, number of treatments, and size or type of ranula. No complications were noted. Our findings indicate that bleomycin, while safe for use in various head and neck malformations, is of limited utility in ranula therapy when the offending gland is not addressed primarily.

Sclerotherapy of ranulas with OK-432 – a prospective, randomized, double-blinded placebo-controlled study

Background Ranula is a rare benign cystic lesion in the floor of the mouth, which can herniate through the mylohyoid muscle and become a plunging ranula. Treatment for ranulas is currently surgical excision of the sublingual gland. Sclerotherapy with OK-432 is a well-established treatment of lymphatic malformations, but not yet thoroughly evaluated on ranulas. Objectives: To evaluate sclerotherapy of ranulas with OK-432 in a randomized double-blinded trial. Materials and methods 20 patients with plunging or intraoral ranula were randomized to two double-blinded injections with OK-432 or saline. Effect on the ranula and evaluation of symptoms and QOL were investigated. Results Treatment response differed significantly between OK-432 and placebo, p = .041(student’s T-test). All patients with intraoral ranulas had a complete response, but only 1/4 of the patients with plunging ranula. The inflammatory reaction after injection with OK-432 caused a mild to moderate impact on QOL. No serious complications were observed. Conclusion This study suggests that sclerotherapy with OK-432 in ranula is a very effective treatment for intraoral ranulas, but possibly less useful in plunging ranulas. Significance This is a limited study, but we believe that sclerotherapy with OK-432 should be recommended as primary treatment at least for intraoral ranulas.

The importance of sublingual gland removal in treatment of ranulas: A large retrospective study.

Investigate the efficacy of sublingual gland removal for the treatment of simple and plunging ranulas. After IRB approval, a retrospective review was performed on patients treated for a ranula from February 2013 to May 2018 at Texas Children's Hospital in Houston, TX. Clinical data was collected from medical records and patients were contacted in November 2018 to obtain additional information about recurrences or complications. This study included 52 patients with ranulas (10 plunging, 42 simple; M:F 21:31) with a mean age of 9.68years. Eighteen patients provided information in the extended follow-up period. Simple ranulas were treated with intraoral excision of the cyst and the sublingual gland (27 cases), marsupialization (7 cases), intraoral excision of the cyst alone (7 cases), and intraoral excision of the cystic component and subsequent marsupialization after recurrence (1 case); intraoral excision of the sublingual gland was not associated with any recurrence. Plunging ranulas were treated with intraoral excision of the cyst and/or sublingual gland (7 cases) or with a transcervical approach (3 cases). One patient was initially treated with sclerotherapy before undergoing intraoral excision of the sublingual gland. Two patients treated with transcervical excision of the cyst experienced recurrence compared to no recurrence with intraoral excision of the sublingual gland. Intraoral removal of the sublingual gland is the most effective treatment for both simple and plunging ranulas. Plunging ranulas must be considered in patients presenting with a submandibular and submental cystic mass given intraoral extension may not be apparent.

Percutaneous treatment of ranulas: ultrasound-guided drainage with salivary gland chemical ablation

BackgroundRanulas are salivary pseudocysts in the floor of the mouth adjacent to damaged salivary glands. Current surgical management is drainage of the ranula with removal of the offending gland. An analogous percutaneous procedure could potentially offer similar treatment efficacy in a more minimally invasive way.ObjectiveTo evaluate the outcomes of a cohort of patients with ranulas treated with percutaneous ranula aspiration and chemical ablation of the source salivary gland to see whether this technique could be proposed as a minimally invasive treatment alternative.Materials and methodsThis retrospective single-center study evaluated 24 patients treated percutaneously for ranulas between January 2004 and December 2014. All patients were treated with percutaneous ranula aspiration and chemical ablation of the offending salivary gland. Treatment success and any complications were recorded.ResultsComplete ranula eradication was successfully accomplished in 87.5% of the patients with no complications.ConclusionInitial results suggest that our technique of percutaneous aspiration of ranulas and chemical ablation of the source salivary gland is safe and effective.

Marsupialization as a ranula management: case report

Objective: Ranula is a form of cyst occuring because of obstruction major salivary gland. Ranula is a phenomenon of sublingual gland duct retention in mouth floor. That results in a bluish swelling in mouth floor. It usually occurs unilaterally and appears as a fluctuating swelling like a frog belly. Methods: A 9 years old girl patient complained of a swelling in her mouth floor. Clinical examination shows a reddish blue mass in her mouth floor with a size of 4x3x3 cm pushing the tongue upward. Patient came with a good general condition and it can impair speaking, eating or swallowing. This case is managed by marsupialization. The following is incision as long as 2 cm in the mass surface only in mucous facing directly to the mass capsule, bleeding control. The entire mass liquid is removed until the iodoform gauze is filling as antiseptic, the margins of the mucosa are suture Results: Etiology of ranula is still unknown but it is suspected because of trauma, and salivary gland obstruction. Clinically, ranula has an apearrance as a swelling in the mouth floor pushing the tongue upward, it is more likely to be unilaterally rather than bilaterally. That swelling has a thin transparant wall, reddish blue, grows slowly and appears lika a frog belly. Big size ranula will push salivary gland duct and impairs salivary flow. Conclusion: Marsupialization as the treatment of ranula has a good result.

Treatment of Ranula with Marsupialization Technique: a Case Report

Treatment of Ranula with Marsupialization Technique: a Case Report

Ok-432 (Picibanil) In the Treatment of Ranulas

OK-432 is used as a chemotherapeutic agent in the treatment of cancer. Since 1987, however, it has been successfully used as a sclerotherapy agent in the treatment of cystic pathologies. A cystic malformation, known as ranula, is very common in the head and neck region. For this reason, sclerotherapy with OK-432 started to be used in the treatment of ranulas in the 1990s.

Anterograde excision of a sublingual gland: new surgical technique for the treatment of ranulas

Wharton's duct is dissected in a retrograde direction from the orifice of the duct to the hilum of the submandibular gland when the gland is being excised conventionally. Here we describe an anterograde technique, in which Wharton's duct is dissected in an anterograde direction from the hilum of the submandibular gland to the orifice of the duct. This prospective clinical study included 50 consecutive patients with ranulas who had anterograde excision of the sublingual gland between May 2012 and January 2015. The intraoral incision was similar to that for conventional excision. Wharton's duct and other important anatomical structures located in the space behind the sublingual gland were all identified at the beginning of the procedure, followed by anterograde dissection of Wharton's duct. After the glandular tissue lateral to the duct had been incised completely, the duct was exposed and the gland cut into two parts. Finally, the two parts were removed, and the ranula ruptured. The patients were followed up from 6 months-2 years. There were no complications. Anterograde excision of the sublingual gland is based on the anatomy, and this reduces the risk of complications after removal of a ranula.

ガマ腫に対する舌下腺全摘出術の有用性

ガマ腫に対する舌下腺全摘出術の有用性

Treatment of Ranula And Mucocele in Babies With Cryosurgery: Report of Two Cases

Ranula develops from an extravasation of mucus after trauma to the sublingual gland or obstruction of the ducts. Mucoceles are common lesions defined as mucus-filled cavities characterized by an accumulation of liquid or mucoid material; they occur in various sizes. Although surgical excision is the most common type of therapy, cryosurgery has recently been used. Two cases of extravasation of mucus are described. Infant, 4 months, with a clinical suspicion of ranula and infant, 3 months, with a clinical suspicion of mucocele at the inferior labial mucosa. Both were treated with cryosurgery, although this type of surgery is uncommon in the oral cavity, especially in infants. The literature describes different treatment options, including intralesional corticosteroid injection and micromarsupialization in pediatric patients. In this report we demonstrate a conservative treatment for ranulas and mucoceles using cryosurgery in infants.

OK-432 treatment of ranula extending to the parapharyngeal space

Conclusions: Our results confirmed that OK-432 therapy is simple, easy, safe, and effective and can be used as a substitute for surgery in the treatment of ranula extending to the parapharyngeal space. Objective: The aim of this study was to evaluate the outcome and complications of the OK-432 treatment of patients with ranula extending to the parapharyngeal space. Methods: This was a case series with planned data collection at Yamagata University and Fukase clinic. We tried this therapy in six patients with ranula extending to the parapharyngeal space, between January 2001 and February 2012. We injected OK-432 solution into the lesion with an 18 or 27 gauge needle depending on the patient's condition (location and size of ranula and complications). This treatment was performed on an outpatient basis without hospitalization. Results: Disappearance or marked reduction of the lesion were observed in all patients who had this therapy, and local scarring and deformity of the injection sites did not occur in any patients. As side effects, local pain at the injection site and fever (37–39°C) were observed in 40% of the patients who had this therapy, but such problems resolved within a few days.

Treatment of Ranula by OK-432: Pearls and Pitfalls

Abstract: Objectives: Intralesional injection therapy with OK-432 was developed as a treatment modality for operatively difficult lymphangioma and is currently becoming a first choice treatment of this disease. The aim of this article was to evaluate the outcome and complications of the treatment of patients with ranula by OK-432 therapy. Study Design and Setting: Case series with planned data collection at Yamagata University and Fukase clinic. Subjects and Methods: We tried this therapy in 90 patients with ranula between January 2001 and February 2012. We injected OK-432 solution into the lesion with a 27 gauge needle to prevent the leak of the agent out of the ranula. This treatment was performed at an outpatient basis without hospitalization. Results: Disappearance and marked reduction of the lesion were observed in 88 patients who had this therapy, and local scarring and deformity of the injection sites did not occur in any patients. As side effects, local pain at the injection site and fever (37to 39 􀀃) were observed in 40% cases of the patients who had this therapy, but such problems resolved within a few days. Conclusion: These results may allow us to speculate that intralesional injection therapy with OK-432 is simple, easy, safe and effective, and can be used as a substitute for surgery in the treatment of ranula.

Treatment of Ranula by OK‐432: Pearls and Pitfalls

Objective: Intralesional injection therapy with OK-432 was developed as a therapy for operatively difficult lymphangioma (cystic hygroma) and is currently becoming a first choice treatment of this disease. The aim of this article was to evaluate the outcome and complications of the treatment of patients with ranula by OK-432 therapy. Method: We tried this therapy in 55 patients with ranula between January 2001 and February 2012. We injected OK-432 solution into the lesion with a 27-gauge needle to prevent the leak of the agent out of the cyst. We performed this treatment on an outpatient basis without hospitalization. Results: Disappearance and marked reduction of the lesion were observed in all patients who had this therapy, and local scarring and deformity did not occur in any patients. As side effects, local pain at the injection site and fever (37 to 39°C) were observed in few cases of the patients who had this therapy, but such problems resolved within a few days. Dermoid cyst might be kept in mind to make differential diagnosis for ranula. Conclusion: These results may allow us to speculate that intralesional injection therapy with OK-432 is simple, easy, safe, and effective, and it can be used as a substitute for surgery in the treatment of ranula.

Modern management and pathophysiology of ranula: Literature review

There is a lack of consensus about the appropriate treatment of ranula. The objective of the present investigation was to produce a scientific basis for treatment. A review of the relevant literature is interpreted in the light of improved knowledge about the local anatomy and the pathophysiology of the salivary glands. The oral and plunging ranulas are cystic extravasation mucoceles that arise from the sublingual gland and usually from a torn duct of Rivinus. The sublingual gland is a spontaneous secretor and the salivary flow is resistant to obstruction, which is caused by fibrosis induced by the extravasation. The submandibular gland is not a spontaneous secretor, is less resistant, and does not give rise to ranulas. Effective treatment is removal of the involved unit of the sublingual gland or inducing sufficient fibrosis to seal the leak through which the mucus extravasates.

ガマ腫１６例の臨床的検討

Ranulas are conventionally treated by total resection, marsupialization or intracystic OK-432 injection. We clinically studied 16 such cases from 2000 to 2008—15 sublingual and 1 mixed. The ranula was excised in 7 cases with recurrence in 42.9%, marsupialized in 3 with 100% recurrence, the sublingual gland totally resected in 4 with no recurrence, and OK-432 injected intracystically in 2 with 50% recurrence. Our results thus suggest that total sublingual gland resection is an effective method for the treatment of ranula.

Treatment of ranula using carbon dioxide laser – Case series report

Ranulas are mucus extravasation phenomenon formed after trauma to the sublingual gland or mucus retention from the obstruction of the sublingual ducts. There are various methods for treating ranulas, including marsupialization with or without open packing, excision of ranula with or without removal of sublingual gland, and laser excision and vaporization of ranula. The authors present a case series report on the use of carbon dioxide laser treatment for ranula and a literature review of cases treated using carbon dioxide laser. The authors' experience and reports in the literature indicate that carbon dioxide laser excision of ranula is safe with minimal or no recurrence.

Treatment of ranulas

Ranulas present as a painless cyst on the floor of the mouth. They present in varying sizes, ranging from the small ranula on the floor of the mouth to large plunging ranulas that extend through to the neck. Treatment options vary depending on the size of the ranula and the operative techniques. This article describes the authors' methods for treating ranulas.

Hydrodissection for Complete Removal of a Ranula

Hydrodissection has been used in various surgical fields to facilitate excision in both routine and difficult cases. This procedure involves the injection under pressure of saline and lidocaine with 1:100,000 epinephrine into the dissection plane. Removing a ranula without rupturing it can be a tedious and time-consuming process. Therefore, we used hydrodissection to assist us in performing these procedures. To review our experience with the treatment of ranulas, we performed a retrospective study of 38 patients who had undergone hydrodissection for ranula removal between January 1996 and December 2002 at our academic tertiary care hospital. Compared with other removal techniques, we found that hydrodissection was associated with less bleeding, fewer incidents of neural and soft-tissue damage, and a lower recurrence rate. In addition to reporting our study results, we also describe our hydrodissection technique, which is relatively simple, effective, and convenient for otolaryngologists.