Treatment Of Heat Stroke Research Articles

Ineffectiveness of dantrolene sodium in the treatment of heatstroke: Bouchama A, Cafege A, Devol E, et al Crit Care Med 19:176–180 Feb 1991

Ineffectiveness of dantrolene sodium in the treatment of heatstroke: Bouchama A, Cafege A, Devol E, et al Crit Care Med 19:176–180 Feb 1991

Ineffectiveness of dantrolene sodium in the treatment of heatstroke

To determine the efficacy of dantrolene sodium in the treatment of heatstroke. Randomized, double-blind, placebo-controlled trial. Heatstroke center in Makkah, Saudi Arabia. Fifty-two adult patients with heatstroke. Patients were assigned to receive either dantrolene sodium (2 mg/kg body weight iv) or placebo. Conventional cooling therapy was initiated in all. There was no significant difference in the mean cooling times for the treatment and control groups (67.9 vs. 69 min). There was only one death in the control group. Complications were seen in six (23%) patients receiving dantrolene sodium and seven (27%) patients receiving placebo; the difference was not statistically significant. There was no significant difference in the mean number of hospital days (4.7 +/- 2.0 vs. 2.9 +/- 0.9 days). Treatment with dantrolene sodium at the dose used, did not prove beneficial to patients with heatstroke.

Iced gastric lavage for treatment of heatstroke: Efficacy in a canine model

Iced gastric lavage for treatment of heatstroke: Efficacy in a canine model

Treatment of Heat Stroke

<h3>To the Editor.—</h3> Two letters have appeared inThe Journalrecently (by Lydiatt and Hill entitled "Treatment of Heat Stroke by Dantrolene" [1981; 246:41] and by Meyers and Meyers entitled "Thermic Stress Syndrome" [1982;247:2098]) recommending that heat stroke patients receive dantrolene sodium intravenously as a specific treatment for hyperthermia. Lydiatt and Hill described a patient with heat stroke who allegedly responded favorably to dantrolene who had already been immersed in ice for 30 minutes. Meyers and Meyers reported no experience whatsoever, but they suggested that hyperthermia in heat stroke, the neuroleptic malignant syndrome, or malignant hyperthermia occurs by a common mechanism and, accordingly, that each should respond to dantrolene therapy. While we can be certain that dantrolene is effective in the treatment of malignant hyperthermia and possibly in some cases of the neuroleptic syndrome, I would like to challenge the authors of these articles to cite scientific evidence that dantrolene

Treatment of heat stroke

Treatment of heat stroke

Epidemiology of heat illnesses during the Makkah Pilgrimages in Saudi Arabia.

A review of the literature shows that our knowledge of the epidemiology of heat illnesses on a global and regional level is still lacking. Until now most of the information has come from the experience of European armies in hot environments. Recently increased interest has been shown following the epidemics of heat illnesses affecting civil communities in the United States. Of great importance and unique for the study of heat illness is the start of the hot cycle of the Makkah Pilgrimage which will continue for the next 15-16 years. Approximately two million people, the majority of whom are at great risk, will be exposed to the extremes of hot weather in May-September. Thousands of heat stroke cases are expected to occur. In this paper the conditions prevailing during the annual Makkah Pilgrimage are described as well as a review of the epidemiological and clinical findings observed by the author during the pilgrimages of 1980/81 when 176 cases and 467 cases of Heat Stroke were seen and treated respectively and a new physiological method of treatment of heat stroke which proved very successful in clinical field trials was introduced.

The prevention and treatment of heatstroke in psychiatric patients.

Heatstroke is a serious medical condition that affects people in all climates. There is some preliminary evidence that psychiatric patients and those on psychotropic drugs are particularly susceptible. The author discusses the signs and symptoms of heatstroke, the factors that lead to it, and the appropriate preventive and treatment measures that should be taken. He concludes that heatstroke in psychiatric patients is totally preventable, but that should heatstroke occur, quick recognition and treatment can prevent death.

Thermic Stress Syndrome

<h3>To the Editor.—</h3> The letter by James D. Lydiatt, MD, and Gary E. Hill, MD, entitled "Treatment of Heat Stroke by Dantrolene" (1981;246:41), again emphasizes that "heat stroke" and "malignant hyperthermia" may be identical conditions with different triggering mechanisms that respond to the same treatment. Other variations of thermic stress syndrome are "sudden death syndrome in athletes," "idiopathic recurrent rhabdomyolysis with myoglobinuria," "exercise myohemoglobinuria," "fulminant hyperthermic porcine stress syndrome" and "neuroleptic malignant syndrome." Each of these syndromes has been described in the literature with scant recognition that other authors, using different titles, have described what seems to be the same malady. Measures used for successful treatment of fulminant hyperthermic porcine stress syndrome, malignant hyperthermia, and heat stroke appear to be the same.¹In 1973, Meltzer²discussed the similarities between the neuroleptic malignant syndrome and malignant hyperpyrexia. Probably, treatment will prove to be the same. These thermic stress syndromes

Harrison's Principles of Internal Medicine

Every three or four years the conscientious physician must again answer the recurrent question of whether to buy the newest edition of Harrison's textbook of medicine. The physician may ask, Are there substantial changes in the text? Are there important additions? Although the changes in the newest edition are mostly not substantive, they are indeed numerous and of some importance. For example, infectious mononucleosis is now discussed with diseases of viral origin rather than being included in the section Diseases of Uncertain Etiology, a section that has now shrunk from four to just three listings. As another example, in the eighth edition, the discontinuation of cold baths in treatment of heat stroke is recommended when the rectal temperature falls below 101 F (38.3 C), while in the seventh edition, the recommendation is made to do so when the temperature falls below 103 F (39.5 C). I personally care more what

The immediate treatment of heatstroke

The nature, diagnosis and treatment of heatstroke has been discussed. The importance of prevention, recognition and active and early treatment has been emphasised.

STAT treatment for heatstroke

STAT treatment for heatstroke

The acute treatment of heat stroke.

The acute treatment of heat stroke.