Introduction Balloon kyphoplasty is a well-accepted treatment for symptomatic compression fractures. Concern has been raised regarding unacceptable morbidity and poor outcomes in very elderly patients who undergo the procedure. This study was undertaken to evaluate the safety and efficacy of a series of very elderly patients who underwent balloon kyphoplasty. Materials Methods A retrospective cohort evaluation was performed of a consecutive series of 162 patients over age 80 who underwent treatment for compression fractures between 2006 and 2013 using the balloon kyphoplasty technique. The indication for treatment included pain unresponsive to non-surgical management in all cases. Results All procedures were successfully completed under general anesthesia. There were 43 men and 119 women (mean age 88, range 80-99 years). One hundred forty-two fractures were osteoporotic (23 had history of trauma), and 20 were pathologic. Fifty patients were treated in an outpatient setting. A total of 253 levels were treated, most common being L1 (n=38) and T12, L2 (n=35 each). Ninety- one patients had a single level treated, 56 had 2 levels treated, and 15 had 3 levels treated. The range of levels treated spanned from T4 (n=2) through L5 (n=11). Back pain improvement was used as the primary outcome measure. The mean VAS score for back pain improved from 9 to 3.5 (p<0.0001). There were no cases of surgical site infections, cement extravasation, or new neurologic deficit for the entire cohort. Twenty-nine patients expired due to causes unrelated to the procedure during the follow-up period. Twenty- two (14%) patients underwent a second procedure for a new compression fracture after the index treatment at a mean interval of 7 weeks; 15 of these (68%) were performed at a level adjacent to the index level. Conclusion Balloon kyphoplasty is a safe and highly effective treatment for symptomatic compression fractures, even for very elderly patients. The procedure can be performed in an outpatient setting. Age alone should not be an exclusion criterion for candidate patients. Keywords: Balloon kyphoplasty, fracture, osteoporosis, surgery in the elderly, compression fractures