This project evaluated pharmaceuticals and personal care products (PPCPs) concentrations in drinking water originating from Lake Erie. Raw and treated water samples were collected from the local water treatment plant in Erie, Pennsylvania over a 10 month period. Along with grab samples, long-term samples were collected using Polar Organic Chemical Integrative Samplers (POCIS). The samples were analyzed for 17 PPCPs (acetaminophen, ampicillin, atrazine, bisphenol-A, caffeine, carbamazepine, cimetidine, ciprofloxacin, digoxin, gemfibrozil, ibuprofen, metformin, naproxen, simazine, sulfamethoxazole, sulfathiazole, trimethoprim) in raw and treated drinking water. For grab samples, six of the 17 PPCPs were found at detectable levels in raw or treated drinking water including atrazine, bisphenol-A, caffeine, ibuprofen, metformin, and simazine. Detectable PPCP levels in treated water samples were usually lower than those in raw water. For long-term samples, an additional four PPCPs (ten total) were found at detectable levels including gemfibrozil, naproxen, sulfamethoxazole, and trimethoprim. Aqueous phase concentrations of PPCPs were estimated using sampling rates, deployment periods, and analytical results of POCIS samplers.