PURPOSE: To compare the efficacies of treadmill and sit-to-stand workstations in decreasing daily sedentary behavior (SED) during a 12-month, cluster-randomized trial with an intent to treat design in sedentary overweight office workers. METHODS: Sixty-six office workers (7 male, 59 female, age ± SD = 45.3 ± 12.3 y., BMI ± SD = 32.5 ± 5.7 kg/m2) were cluster randomized to one of 3 groups: (i) seated desk control (C) (N=21), (ii) sit-to-stand desk (D) (N=23), or (iii) treadmill desk (T) (N=22). Change in mean daily SED, standing and stepping time were measured using activPALTM accelerometers adhered to the dominant thigh at baseline (B), month-3 (M3), month-6 (M6) and month-12 (M12). Inclusion in analyses required ≥ 4 valid accelerometer wear days (i.e., ≥ 10 h. of wake wear time). Missing mean daily SED, standing and stepping hours were imputed using multiple-imputation. Between and within group differences in mean daily wake-time spent SED, standing, and stepping after M3, M6 and M12 were analyzed with random intercept mixed linear models accounting for repeated measures and clustering effects. Bonferroni corrections were used during pairwise post-hoc comparisons to correct for multiple hypotheses testing. RESULTS: Mean monitoring time (i.e., mean sensor wear days and daily time) did not significantly vary between or within groups. There were no significant within group changes in mean daily SED time. Mean daily standing time significantly increased in group D from B to M3 (Mean ± SD = 1.03 ± 2.24 h [7.72%], p = 0.03, Cohen’s D = 0.46), which was sustained through M12. Similarly, group T increased mean standing time from B to M3 (Mean ± SD = 1.23 ± 2.56 h [13.28 %], p = 0.025, Cohen’s D = 0.48), but these increases were negated at M12. Mean daily stepping time increased significantly in group D from B to M12 (Mean ± SD = 0.81 ± 1.61 h [2.65 %], p = 0.019, Cohen’s D = 0.50). No significant between group differences in SED, standing or stepping time were observed at M3, M6, or M12. CONCLUSION: Workstation-based workplace interventions may result in moderate short-term daily reductions in SED and increased physical activity among seated office workers. Sustaining these short-term behavioral improvements may not be achievable through passive environmental modifications alone, and may require additional active behavior change strategies.
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