Since the beginning of the COVID-19 pandemic, many travel restriction policies were implemented to reduce further spread of the virus. These measures significantly affected travel demand to levels which could not have been anticipated by most planners in transportation agencies. As the pandemic has proven to have significant short-term impacts, it is anticipated that some of these impacts may translate to longer-term impacts on overall travel behavior and the movement of people and goods. Beyond the pandemic, the observed travel patterns during this period also provides a great opportunity for planners to assess policies such as work from home and remote learning as strategies to manage travel demand. This study provides a scenario analysis framework to re-evaluate travel demand forecasts under uncertain future conditions using the Maryland Statewide Transportation Model (MSTM). Model parameters associated with working from home, household income, changes in discretionary travel, distance learning, increased e-commerce, vehicle occupancy and mode choice were identified. Parameter values were assigned under the various scenarios using employer surveys on workforce teleworking and observed data on e-commerce growth and shopping behavior. The main findings of this study capture the sensitivities of systemwide vehicle miles travel, and vehicle hours travel under different scenarios and implications on future investment decisions.The study found that future investments under the scenarios remain beneficial to systemwide performance and therefore justified. Although this study focuses on the state of Maryland, the scenario framework and parameter definitions can be used in other states or agencies within a travel demand model environment.