Er,Cr:YSGG laser, a hard tissue laser absorbed well by chromophore water apart from hydroxyl appetite crystals can be used in the excision of soft tissue lesions. Aims and objectives: To assess the effectiveness of Er, Cr: YSGG laser in the excision of four different soft tissue lesions and the objective was to assess pain during and after procedure, bleeding during procedure and wound healing after 1 week. Materials and methods: Four patients with different soft tissue lesions, such as peripheral ossifying fibroma, traumatic fibroma, intraoral lipoma and fibroma of the gingival. Er, Cr: YSGG laser with a wavelength of 2,780 nm (Waterlase, MD, Biolase, USA) with the settings of 1.50 W, air 30% and water 10%, MT, H mode, 25 Hz was used and pain assessed by behavioral pain rating scale, ‘faces’ pain rating scale and visual analog scale, bleeding and wound healing by visual method with photographs. Results: No discomfort to the patient during and after laser procedure, no local anesthesia needed, no suture, no antibiotics were prescribed. Minimal bleeding was dere. No edema and good wound healing was observed. Conclusion: Er, Cr: YSGG laser can be used as an alternative to conventional scalpel excision.
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