In recent years, fatigue cracking in orthotropic steel bridge deck pavements has become a significant concern, so the investigation of the mechanical response of the pavement layer has become a central focus in pavement structure design. This experiment subjected a full-scale specimen to a constant amplitude dynamic load of 60 kN to 300 kN over 2 million cycles. Throughout the testing, a circulating water bath elevated the temperature of the pavement layer from 15 °C to 50 °C. Key locations were monitored for strain and deflection data, facilitating an investigation into the mechanical response of the epoxy asphalt pavement system under the effects of temperature and load. The results indicate that the maximum transverse strain at the bottom of the steel deck occurs at the U-rib weld aligned with the load center, reaching 190% of the initial loading strain. Meanwhile, the maximum transverse strain on the pavement surface is observed at the U-rib weld adjacent to the loaded area, measuring 167% of the initial strain. The maximum longitudinal strain is lower than the maximum transverse strain. In the load zone, the longitudinal strain between the U-ribs exceeds that at the U-rib weld. Both transverse strain and relative deflection increase as the load intensifies. The relationship between transverse strain and applied load is characterized by an exponential function, while deflection exhibits a cubic relationship with the applied load. Elevated temperatures also contribute to increased transverse strains at both the bottom of the steel deck and the pavement surface, following an exponential trend. Relative deflection is primarily influenced by the applied load and remains relatively unaffected by temperature variations. When accounting for the coupling of load and temperature, the maximum transverse strains at both the bottom of the steel deck and the pavement surface can be modeled as an exponential function of the independent variables: load and temperature.