This paper introduces a novel partially encased channel–concrete composite (PECC) column for modular buildings, aiming to eliminate the need for cast-in-place concrete and facilitate rapid assembly. The PECC column consists of two prefabricated modules connected by high-strength bolts. To evaluate the column's viability, six slender specimens—one bare steel column and five composite columns—were tested under axial and eccentric compression. Variables considered included the presence of concrete, the type of transverse connections, bolt spacing, and load eccentricity ratio. The compression performance of the PECC columns was analyzed by examining their failure patterns, load–deformation responses, initial stiffness, compressive capacity, and ductility. Test results revealed that the PECC columns failed due to global buckling, concrete spalling, and crushing. The bolted connections effectively prevented module separation, enabling the PECC columns to exhibit favorable compressive behavior. The reinforced concrete encased in the channel delayed the column's buckling failure, increasing its initial stiffness and compressive capacity by 98% and 198%, respectively. Using perforated steel plates instead of transverse links between the concrete and the channel enhanced the column's initial stiffness by 20% but had little effect on its compressive capacity. Reducing the bolt spacing improved the column's initial stiffness and compression resistance by 50% and 5%, respectively. Additionally, a finite element model for the PECC columns was developed and validated against test results. Finally, simplified formulas derived from Eurocode 4 were proposed to estimate the resistance of PECC columns under axial and eccentric compression.