Transverse Interaction Research Articles

Effect of Electric Fields on the Mechanical Mechanism of Regorafenib-VEGFR2 Interaction to Enhance Inhibition of Hepatocellular Carcinoma.

The interaction between molecular targeted therapy drugs and target proteins is crucial with regard to the drugs' anti-tumor effects. Electric fields can change the structure of proteins, which determines the interaction between drugs and proteins. However, the regulation of the interaction between drugs and target proteins and the anti-tumor effects of electric fields have not been studied thoroughly. Here, we explored how electric fields enhance the inhibition of regorafenib with regard to the activity, invasion, and metastasis of hepatocellular carcinoma cells. We found that electric fields lead to an increase in the normal (adhesion) and transverse (friction) interaction forces between regorafenib and VEGFR2. In single molecule pair interactions, there are changes in specific and nonspecific forces. Hydrogen bonds, hydrophobic interactions, and van der Waals forces are the main influencing factors. Importantly, the increase in the adhesion force and friction force between regorafenib and VEGFR2 caused by electric fields is related to the activity and migration ability of hepatocellular carcinoma cells. The morphological changes in VEGFR2 prove that electric fields regulate protein conformation. Overall, our work proves the drug-protein mechanical mechanism by which electric fields enhance the anti-tumor effect of regorafenib and provides insights into the application of electric fields in clinical tumor treatment.

A fluorobenzene-bound dysprosium half-sandwich dication single-molecule magnet.

Dysprosium single-molecule magnets (SMMs) with two mutually trans-anionic ligands have shown large crystal field (CF) splitting, giving record effective energy barriers to magnetic reversal (U eff) and hysteresis temperatures (T H). However, these complexes tend to be bent, imposing a transverse field that reduces the purity of the m J projections of the CF states and promotes magnetic relaxation. A complex with only one charge-dense anionic ligand could have more pure CF states, and thus high U eff and T H. Here we report an SMM with this topology, a half-sandwich Dy(iii) complex [Dy(Cp*)(FPh)6][{Al[OC(CF3)3]3}2(μ-F)]2 (1-Dy; Cp* = C5Me5), and its Y(iii) analogue 1-Y; 1-Dy exhibits U eff = 545(30) cm-1 and T H = 14 K at sweep rates of 22 Oe s-1. The Cp* ligand imposes a strong axial CF, which is assisted by one axial fluorobenzene; the five equatorially-bound neutral fluorobenzenes present only weak transverse interactions to give a pseudo-pentagonal bipyramidal geometry. The salt metathesis reaction of 1-Y with KCp''' (Cp''' = {C5H2(SiMe3)3-1,2,4}) gave the sandwich complex [Y(Cp''')(Cp*)(FPh)2][{Al[OC(CF3)3]3}2(μ-F)] (4-Y), showing that the fluorobenzenes of 1-Y are easily displaced. We envisage that these methodologies could be adapted in future to prepare high-performance axial Dy SMMs with ligands that are more sterically demanding than Cp*.

Modeling of transverse tangential interaction of the foot with the supporting surface

Modeling of transverse tangential interaction of the foot with the supporting surface

High-frequency transverse acoustic interactions between two lean-premixed hydrogen combustors connected with cross-fire and cross-talk sections

Large-scale inter-combustor thermoacoustic interactions occur frequently in modern can-annular gas turbine combustion systems due to the presence of an annular cross-talk section upstream of the first stage turbine stator vanes. Although the whole system's modal dynamics depend on the relative dominance of low-frequency planar or high-frequency transverse acoustic waves, the majority of prior studies have chiefly focused on longitudinal mode instabilities. Motivated by the paucity of detailed information, here we examine high-frequency transverse acoustic interactions between two adjacent lean-premixed hydrogen combustors connected via two different pathways, known as cross-fire (XF) and cross-talk (XT) sections. We observe that the dual-combustor system undergoes high-frequency spinning mode in the clockwise direction, manifested as well-defined limit cycles with peak-to-peak amplitude of around 10 kPa. The transverse pressure oscillations, in contrast to the well-established low-frequency mutual synchronization dynamics, are not fully synchronized even in the presence of cross-talk communication. This situation leads to the formation of two closely-spaced 1T modes at 4.76 and 4.86 kHz in the respective hydrogen combustors, accompanied by the beating of the pressure fluctuations solely in the XF tube section. Remarkably, the pressure waves induced near the XF tube section tend to lag behind the pressure waves spinning in the injector face, demonstrating the existence of the angular shift characteristically connected to the high-frequency transverse combustion dynamics.

Transverse Spin-Orbit Interaction of Light.

Light carries both longitudinal and transverse spin angular momentum. The spin can couple with its orbital counterpart, known as the spin-orbit interaction (SOI) of light. Complementary to the longitudinal SOI known previously, here we show that transverse SOI of light is inherent in the Helmholtz equation when transverse spinning light propagates in curved paths. It lifts the degeneracy of dispersion relations of light for opposite transverse spin states, analogous to the Dresselhaus effect. Transverse SOI is ubiquitous in nanophotonic systems where transverse spin and optical path bending are inevitable. It can explain anomalous effects like the dispersion relation of surface plasmon polaritons on curved paths and the energy level of whispering gallery modes. Our results reveal the analogies of spin photonics and spintronics and offer a new degree of freedom for integrated photonics, spin photonics, and astrophysics.

Birefringence-free photoelastic modulator with centimeter-square aperture operating at 2.7 MHz with sub-watt drive power.

Photoelastic modulators are optical devices with a broad range of applications. These devices typically utilize a transverse interaction mechanism between acoustic and optical waves, resulting in a fundamental trade-off between the input aperture and the modulation frequency. Commercially available modulators with centimeter-square apertures have operating frequencies in the vicinity of 50 kHz. In this work, we experimentally demonstrate a birefringence-free photoelastic modulator operating at approximately 2.7 MHz with a centimeter-square aperture, increasing the operating frequency substantially compared to existing approaches. Using the modulator and polarizers, we demonstrate close to π radians polarization modulation amplitude with sub-watt drive power, translating to nearly 100% intensity modulation efficiency at the fundamental (2.7 MHz) and second-harmonic (5.4 MHz) frequencies.

Transverse Jet Interaction with Hypersonic Crossflow I: Experimental and Numerical Investigations

Applications of transverse jet interaction are widespread in hypersonic aircraft systems. In wind tunnel facilities, it is more convenient to perform jet interaction tests with jet fluids of different compositions and with test models of different sizes from those of the actual aircraft. The paper presents a detailed analysis of the transverse jet interaction with hypersonic crossflow by combining the use of both experimental and numerical tools. A hypervelocity ballistic correlation model HB-1, with a sonic jet nozzle, was designed to provide a simplified flowfield for comparison with the simulations. It is found that the temperature and molecular weight of the injectant gas play an important role in the interactions between the hypersonic flow and transverse jet. The applicability of different scaling parameters for this kind of aerodynamic experiment is discussed at the end of this paper.

Analysis of mechanical response and failure characteristics of tunnels crossing active faults considering axial force and geometrical nonlinearity

Tunnels subjected to active fault dislocation may experience significant damage. This paper establishes a novel methodology and solution procedure for analyzing the mechanical response and failure characteristics of tunnels subjected to active fault dislocation based on an elastic foundation beam model. The proposed methodology includes axial, transverse, and vertical soil-tunnel interaction terms, in addition to geometrical nonlinearity and axial force terms in the governing equation. This approach has a significantly extended application range, effectively addressing the problems encountered in tunnels crossing active faults with diverse crossing angles, dip angles, and fault types. The proposed methodology is verified by comparison to a 3D FEM model with various fault types, experimental tests, and on-site case, and the results are in excellent quantitative and qualitative agreement with the numerical, experimental, and on-site results. When fault displacement is below 0.5 m, disregarding geometric nonlinearity results in calculation errors of approximately 10% to 17% for peak axial force (Nmax), 18% to 22% for peak shear force (Vmax), and 20% to 30% for peak bending moment (Mmax). Finally, the responses caused by different factors, i.e., fault type, fault displacement, tunnel stiffness, and tunnel diameter, are investigated in detail to better understand tunnels crossing active faults. The results show that amongst the various fault types, the Vmax and the Mmax experienced by tunnels subjected to oblique slip-fault dislocation surpass those of other fault types, accompanied by the most extensive failure range. The augmentation of fault displacement, tunnel stiffness, and tunnel diameter precipitates a corresponding escalation in the Nmax, Vmax, Mmax, and failure range. Under oblique-slip fault dislocation, the tunnel undergoes an initial phase of shear failure, followed by tension-bending failure, delineated by distinct fault displacement thresholds of 0.1 m and 0.2 m, respectively. The proposed methodology provides the advantage of reliable stability analysis and design of tunnels crossing active faults.

Exploring the QGP phase above the deconfinement temperature in pp and A − A collisions at LHC energies

In the present work we have analyzed the transverse momentum spectra of charged particles in high multiplicity pp collisions at LHC energies s=5.02 and 13 TeV published by the ALICE Collaboration using the Color String Percolation Model. For heavy ions Pb-Pb at sNN=2.76 and 5.02 TeV along with Xe-Xe at sNN=5.44 TeV have been analyzed. The initial temperature is extracted both in low and high multiplicity events in pp collisions. For A−A collisions the temperature is obtained as a function of centrality. A universal scaling in the temperature from pp and A−A collisions is obtained when multiplicity is scaled by the transverse interaction area. From the measured energy density ε and the temperature the dimensionless quantity ε/T4 is obtained. Our results for Pb-Pb and Xe-Xe collisions show a sharp increase in ε/T4 above T ∼ 210 MeV and reaching the ideal gas of quarks and gluons value of ε/T4∼16 at temperature ∼230 MeV.

Spin-photon interaction in a nanowire quantum dot with asymmetrical confining potential

The electron (hole) spin–photon interaction is studied in an asymmetrical InSb (Ge) nanowire quantum dot. The spin–orbit coupling in the quantum dot mediates not only a transverse spin–photon interaction, but also a longitudinal spin–photon interaction due to the asymmetry of the confining potential. Both the transverse and the longitudinal spin–photon interactions have non-monotonic dependence on the spin–orbit coupling. For realistic spin–orbit coupling in the quantum dot, the longitudinal spin–photon interaction is much (at least one order) smaller than the transverse spin–photon interaction. The order of the transverse spin–photon interaction is about 1 nm in terms of length |zeg| , or 0.1 MHz in terms of frequency eE0|zeg|/h for a moderate cavity electric field strength E0=0.4 V m−1.

Equation of State of Quark–Gluon Matter in the Clustering-of-Color-Sources Approach

In the first few microseconds after the Big Bang, the hot dense matter was in the form of quark–gluon plasma consisting of free quarks and gluons. By colliding heavy nuclei at RHIC and LHC at a velocity close to the speed of light, we were able to recreate primordial matter and observe that matter after expansion and cooling. In the present work, we have analyzed the transverse-momentum spectra of charged particles in high-multiplicity pp collisions at LHC energies s= 5.02 and 13 TeV, published by the ALICE Collaboration, using the Color-String Percolation Model. For heavy ions, Pb–Pb at sNN= 2.76 and 5.02 TeV along with Xe–Xe at sNN= 5.44 TeV have been analyzed. The initial temperature was extracted both in low- and high-multiplicity events in pp collisions. For A−A collisions, the temperature was obtained as a function of centrality. A universal scaling in the temperature from pp and A−A collisions was obtained when multiplicity was scaled by the transverse interaction area. For the higher-multiplicity events in pp collisions at s= 5.02 and 13 TeV, the initial temperature was above the universal hadronization temperature and was consistent with the creation of deconfined matter. From the measured energy density ε and the temperature, the dimensionless quantity ε/T4 was obtained, to obtain the degree of freedom of the deconfined matter.

Improved semi-analytical solution for longitudinal mechanical response of tunnels crossing active faults considering nonlinear soil-tunnel interactions and shear effects

Tunnels crossing active faults are susceptible to severe damage. This study establishes an improved semi-analytical methodology for analyzing the mechanical responses of tunnels subjected to active fault dislocation. The methodology incorporates nonlinear axial, transverse, and vertical soil-tunnel interactions, shear effects, and geometric nonlinearity within its governing equations. Compared with existing methods, the proposed method has a significantly extended application range with improved accuracy, and the solution procedure demonstrates exceptional computational efficiency, with each case typically being solved in less than 1 s. The proposed methodology demonstrates outstanding qualitative and quantitative agreement with 3D FEM results across various fault types, as well as with the results obtained from the model test. Additionally, neglecting shear effects results in approximately 1.11 to 1.20 times higher bending moments and 1.13 to 1.19 times higher shear forces of the tunnel. Finally, a parametric analysis was conducted based on the proposed methodology to investigate the influence of critical parameters, such as fault displacement, buried depth, tunnel diameter, soil cohesion, and soil friction angle, on the tunnel response under fault dislocation. The results suggest that the tunnel responses positively correlate with the fault displacement, buried depth, and soil cohesion. Increasing the fault displacement amplifies the vertical shear force and bending moment asymmetry while increasing buried depth reduces this asymmetry. An increase in the tunnel diameter and soil friction angle is associated with a decrease in the peak axial force and an increase in the vertical shear force and bending moment. Additionally, variations in the friction angle do not exert a significant effect on the transverse shear force and bending moment.

Innovation, Entrepreneurship, Higher Education: Integrated and Transversal Basic Sciences

Peru possesses vast natural wealth in forestry, energy, water, maritime, agricultural, and mineral resources, yet its consumption of derived goods and services is low compared to Mexico and Brazil, where collaboration between universities, industry, and government has driven innovation and sustainable technological development. In this work, we address the transversal interrelation of scientific disciplines such as chemistry, physics, biology, and mathematics. Thus, through an interdisciplinary didactic model, we propose a conceptual framework that fosters understanding and synergy among these disciplines, allowing students to integrate and apply knowledge holistically. This model is structured into five stages: identification of key concepts, classification of transversal interactions, design of didactic activities, assessment of comprehension, and feedback for continuous improvement. This approach aims to develop critical skills and facilitate the practical application of knowledge in complex problems and real-life situations. By integrating these basic natural science disciplines, the quality of learning would be improved, promoting a deeper understanding of natural phenomena. This proposal would be validated through indicators measuring its effectiveness in promoting interdisciplinary integration, critical skills, practical application, and creative, collaborative problem-solving. The objective is to prepare students for the 21st century by fostering creative problem-solving, interdisciplinary collaboration, and critical thinking, with the involvement of teachers and administrators in curricular adaptation and basic science integration. Implementing this educational model could represent a significant evolution in higher education in Peru, enhancing academic and professional training and contributing to economic and social development.

Optically isotropic longitudinal piezoelectric resonant photoelastic modulator for wide angle polarization modulation at megahertz frequencies

Polarization modulators have a broad range of applications in optics. The acceptance angle of a free-space polarization modulator is crucial for many applications. Polarization modulators that can achieve a wide acceptance angle are constructed by attaching a piezoelectric transducer to an isotropic material, and utilizing a resonant transverse interaction between light and acoustic waves. Since their demonstration in the 1960s, the design of these modulators has essentially remained the same with minor improvements in the following decades. In this work, we show that a suitable single crystal with the correct crystal orientation, functioning as both the piezoelectric transducer and the acousto-optic interaction medium, could be used for constructing a highly efficient free-space resonant polarization modulator operating at megahertz frequencies and exhibiting a wide acceptance angle. We construct the modulator using gallium arsenide, an optically isotropic and piezoelectric crystal, and demonstrate polarization modulation at 6 MHz with an input aperture of 1 cm in diameter, acceptance angle reaching ±30∘, and modulation efficiency exceeding 50%. Compared to state-of-the-art resonant photoelastic modulators, the modulator reported in this work exhibits greater than 50-fold improvement in modulation frequency for the same input aperture, while simultaneously reducing the thickness by approximately a factor of 80. Increasing the modulation frequency of photoelastic modulators from the kilohertz to the megahertz regime and substantially reducing their thickness lead to significant performance improvements for various use cases. This technological advancement also creates opportunities for utilizing these devices in new applications.

Root size effects on transverse root-soil interactions

For smaller lateral plant roots in coarse-grained soils, a potentially large relative size of soil particles compared to the roots may affect their transverse resistance. Even for the larger roots of trees, particle size effects may be important, e.g. when testing 1:N reduced scale models in a geotechnical centrifuge. The Discrete Element Method (DEM) was used to investigate this problem. A rigid lateral root segment under transverse loading in plane strain was simulated and compared with Finite Element Method (FEM) simulations, where the soil was modelled as a continuum (no particle size effects). Even at the lower root/particle diameter ratios (dr/D50) investigated (6 to 21), particle size effects on transverse capacity were negligible upon push-in, while during uplift, they were observed for dr/D50 < 8, arising from the dimension of the uplifted soil volume above the root. The material properties of roots are also typically diameter dependent. Further simulations of long flexible roots subject to end rotation were performed employing a beam-on-non-linear-Winkler-foundation approach, using p-y curves obtained from the DEM or FEM simulations. Compared with particle-size related effects, diameter-dependent variation of material properties had a much larger controlling effect on root capacity and stiffness as relevant for plant/tree overturning.

Developing characteristics of subsonic-supersonic shear layers induced by different lobed mixers in the RBCC

The rapid mixing of air and rocket gas is pivotal for enhancing combustion performance in the ejector mode of rocket-based combined-cycle engines. This study experimentally investigated developing characteristics of subsonic-supersonic shear layers induced by sinusoidal- and rectangular-lobed mixers using a subsonic-supersonic shear layer experimental system and an ice-cluster-based planar laser scattering technique. Both sinusoidal- and rectangular-lobed mixers evidently bolstered mixing through the promotion of transverse flow and vortex interactions. Under equivalent conditions, the sinusoidal-lobed mixer offered superior mixing effects. The mixing enhancement of a sinusoidal-lobed mixer exhibited a positive correlation with the wavelength, with excessively small wavelengths potentially impeding mixing. Based on the dimensionless wavelength ratio, a criterion was identified for evaluating the mixing enhancement of the sinusoidal-lobed mixer: a positive mixing enhancement occurred when the dimensionless wavelength ratio was at least 1. Notably, in this study, the shear layer thickness growth rate increased by 12 % when the dimensionless wavelength ratio was 1.905. These findings can offer valuable insights for improving combustion performance via enhanced mixing.

Momentum and mass transport and flow structure characteristics for the unsteady flow in compound channel

In recent decades, the study of steady flow in the compound channel has received much attention, while the flow characteristics of flood in the compound channel are rarely reported. In this paper, the characteristics of the flood propagation under different initial main channel depths are studied using the laboratory experiments and numerical simulation. Results show that the overflowing water from the main channel soon forms the reverse flow after hitting the floodplain sidewall. This reverse flow influences the subsequent overflowing process and significantly enhances the bed shear stress on the floodplain. However, this effect gradually decreases with the flood evolution distance and the increase of the initial downstream water depth. Unsteady transverse transport during flooding inhibits the formation of coherent eddies at the interface between the main channel and floodplain, while the high shear region will extend to the internal of the main channel or floodplain. Complex multi-vortex structures are found on the floodplain due to transverse interaction behavior. The main transverse mass transport takes place in the first half of the period after the flood arrival. It is found that the weir flow equations used in the previous studies are unable to accurately describe the transverse mass transfer between the main channel and floodplain. Secondary currents have a little contribution to the unsteady transverse momentum transport, while the transverse currents and transverse Reynolds stresses have a significant effect. The time when the peak transverse current arrives is later than that when the peak transverse Reynolds stresses does in the current study.

Erratum: Critical Fermi surfaces in generic dimensions arising from transverse gauge field interactions [Phys. Rev. Research 2 , 043277 (2020)

Erratum: Critical Fermi surfaces in generic dimensions arising from transverse gauge field interactions [Phys. Rev. Research <b>2</b> , 043277 (2020)

Thermographic Investigation on Fluid Oscillations and Transverse Interactions in a Fully Metallic Flat-Plate Pulsating Heat Pipe

The present investigation deals with the quantification of fluid oscillation frequencies in a metallic pulsating heat pipe tested at varying heat loads and orientations. The aim is to design a robust technique for the study of the inner fluid dynamics without adopting typical experimental solutions, such as direct fluid visualizations through transparent inserts. The studied device is made of copper, and it is partially filled with a water–ethanol mixture (20 wt.% of ethanol). Heat fluxes locally exchanged between the working fluid and the device walls are first assessed through the inverse heat conduction problem resolution approach by processing outer wall temperature distributions acquired by thermography. The estimated local heat transfer quantities are therefore processed to quantify the fluid oscillatory behavior in every device branch during the intermittent flow and full activation regimes, thus providing a deeper insight into the heat transfer modes. After dealing with a further validation of the inverse approach in terms of oscillation frequency restoration capability, the wall-to-fluid heat fluxes referred to each channel are processed by means of the wavelet method. Scalograms and power spectra of the considered signals are presented for a time-based analysis of the working fluid oscillations, as well as for the identification of dominant oscillation frequencies. Fluid motion is then quantified in terms of the continuity of fluid oscillations and activity of channels by applying a scalogram denoising technique named K-means clustering method. Moreover, a statistical reduction of the channel-wise dominant oscillation frequencies is performed to provide useful references for the interpretation of the overall oscillatory behavior. The link between oscillations and transverse interactions is finally investigated. The vertical bottom-heated mode exhibits stronger fluid oscillations with respect to the horizontal mode, with fluid oscillation frequencies ranging from 0.78 up to 1 Hz. Nonetheless, the fluid motion is more stable in terms of oscillation frequency between channels when the device operates in the horizontal orientation probably due to negligible buoyancy effects. Moreover, thermal interactions between adjacent channels are found to be stronger when the oscillatory behavior presents similar features from channel to channel in horizontal orientation. The proposed method for fluid oscillation analyses in fully metallic flat-plate pulsating heat pipes can be effectively adopted to other flat-plate layouts without any need for transparent windows, thus reducing the overall complexity of experimental set-ups and providing, at the same time, a good insight into the inner fluid dynamics.

Convergence condition of simulated quantum annealing with a non-stoquastic catalyst

The Ising model with a transverse field and an antiferromagnetic transverse interaction is represented as a matrix in the computational basis with non-zero off-diagonal elements with both positive and negative signs and thus may be regarded to be non-stoquastic. We show that the local Boltzmann factors of such a system under an appropriate Suzuki–Trotter representation can be chosen non-negative and thus may potentially be simulated classically without a sign problem if the parameter values are limited to a subspace of the whole parameter space. We then derive conditions for parameters to satisfy asymptotically in order that simulated quantum annealing of this system converges to thermal equilibrium in the long-time limit.