Abstract This study investigates quantum information scrambling (QIS) in a semiconductor quantum dot array. Starting with the 1D Transverse Field Ising model, we expand to more relevant quasi-2D frameworks such as the Heisenberg chain, super-extended Fermi-Hubbard and hardcore Fermi-Hubbard models. Assessing their relevance to semiconductor spin-qubit quantum computers, simulations of multipartite entanglement formation examine qubit encoding strategies’ fidelity, stability, and robustness, revealing trade-offs among these aspects. Furthermore, we investigate the weakly coupled metallic injector/detector (I/D) leads’ significant impact on QIS behavior by employing Ω lead N-single orbital impurities weakly coupled Anderson models. We observe sign flips in spatiotemporal tripartite mutual information I3 which result in significant effects on dynamical quantum entanglement structures and their formation. Exploring carrier number effects, we identify optimal regions for QIS enhancement. Our findings emphasize the necessity of proper qubit encoding and I/D lead influence on quantum devices amidst noise and impurities.