Epigenetic modification of DNA where methyl groups are added at the 5-carbon position of cytosine is known as DNA methylation. It is associated with carcinogenesis, thus capable of serving as markers for detection of cancer. Nanopore analytics provides an easier and quicker route to detect methylated sites by avoiding complicated bisulfite treatment and polymerase chain reaction amplification. Graphene has a thickness of a single atom, thereby holding the potential to detect the methylation at single-site resolution. In this work, we use a self-consistent Poisson-Boltzmann formalism to simulate the translocation of methyl-CpG (MBD) proteins bound to a DNA molecule in a graphene nanopore, and detect the methylated sites along the DNA strand by computing both ionic current using molecular dynamics simulations and transverse sheet current via tight binding Hamiltonian based none-equilibrium Green's function approach.1 Evident dips are recorded in the ionic current trace through the nanopore for each methylation site, as expected, suggesting a single-site resolution. The graphene membrane with added quantum point contacts, by means of transverse sheet currents, can also detect the methylated site through local jumps in the variance of the measured transverse current. The proposed measurement strategy allows for real time, fast and high resolution DNA methylation detection.21. Girdhar, A., Sathe, C., Schulten, K., & Leburton, J. P. (2013). Graphene quantum point contact transistor for DNA sensing. Proceedings of the National Academy of Sciences, 110(42), 16748-16753.2. Sarathy, A., Qiu, H., Schulten, K., & Leburton, J. P. Single-site detection of methylation in DNA with graphene nanopores. To be published.