For patients with colorectal malignomas and surgically nonresectable metastases, regional long-term perfusion with chemotherapeutic drugs may be valuable, according to the current view. Several techniques are used for regional long-term liver perfusion; either the arterial approach via the hepatic artery or a venous approach via the portal vein can be chosen. A long-term catheter can be implanted in the hepatic artery or the portal vein during the resection of the primary tumor or during the “second-look” procedure. In either case a laparotomy has to be done.KeywordsPortal VeinHepatic ArteryGuide WireCentral VeinArterial ApproachThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.