Transradial Catheterization Research Articles

Subcutaneous Injection of Nitroglycerin at the Radial Artery Puncture Site Reduces the Risk of Early Radial Artery Occlusion After Transradial Coronary Catheterization: A Randomized, Placebo-Controlled Clinical Trial.

Transradial coronary catheterization is widely used as a diagnostic or interventional procedure for coronary disease. However, it can lead to adverse complications, such as radial artery occlusion. We sought to determine whether preprocedural injection of nitroglycerin at the radial artery puncture site reduces radial artery occlusion. A total of 188 patients undergoing transradial coronary catheterization were randomized in a single-blind fashion to receive subcutaneous injection of 0.5 mL 0.1% nitroglycerin or a placebo at the radial artery puncture site. The participants underwent ultrasound examinations of the radial artery before and at 24 hours after the procedure. Of the 188 patients enrolled, 182 completed the study, as the procedure failed in 2 participants in the nitroglycerin-treated group and 4 in the placebo group. Baseline demographic and clinical characteristics were similar between 2 groups. Comparing the radial artery diameters before and after the operation, there was a statistically significant increase in the nitroglycerin-treated group (2.48±0.45 versus 2.45±0.46 mm; P=0.003) but a decrease in the placebo control group (2.41±0.50 versus 2.46±0.49 mm; P<0.001). Importantly, the incidence of radial arterial occlusion was substantially lower in the nitroglycerin-treated group than in the placebo control group (5.4% versus 14.4%; P=0.04). There was not significant difference in other complications (forearm hematoma and radial artery pseudoaneurysm, respectively), and there was no incidence of cause hypotension or an intolerable headache. Subcutaneous injection of nitroglycerin at the radial artery puncture site dilates the radial artery and reduces the incidence of early radial artery occlusion post-catheterization. URL: https://www.chictr.org.cn. Unique identifier: ChiCTR-IPR-15006559.

Impact of anticoagulation and vasoactive medication on regained radial artery patency after catheterization: a case\u2013control study

BackgroundRadial artery access is the primary approach for coronary interventions due to higher safety profile in comparison to femoral access. Radial artery occlusion (RAO) is the main complication of transradial catheterization that can lead to severe symptoms and a permanent artery occlusion. The incidence of RAO after transradial access ranges from 5 to 38% and data regarding treatment is scarce. Whether anticoagulation and vasoactive medication provides an additional benefit in recovery of radial artery patency (RAP) after catheterization has not been investigated in detail.AimThe objective was to investigate the impact of anticoagulation and vasoactive medication on regained patency after documented RAO following transradial catheterization.Patients and methodsOverall 2635 patients were screened. 2215 (84%) catheterizations were performed by femoral and 420 (16%) by radial access. In 30 patients RAO was observed. In case of RAO patients were classified in three groups: Anticoagulation, anticoagulation added with alprostadil and controls. Follow-up was conducted after 3 months with ultrasound and clinical examination.ResultsEight patients received anticoagulation and 11 patients anticoagulation together with alprostadil. Eleven patients served as controls. Recovery of RAP after catheterization was higher following either treatment (79.5%) compared to controls (0%, p = 0.006). Subgroup analysis yielded a higher RAP recovery in patients treated with anticoagulation (62.5%) as compared to controls (0%, p = 0.002). No effect on regained RAP was found with additional alprostadil therapy (33.3%) compared to anticoagulation therapy (62.5%, p = 0.229).ConclusionRAO should be treated with anticoagulation to regain patency. Addition of vasoactive medication does not lead to further beneficial effects. Further research is needed regarding preventive and therapeutic strategies following RAO.

CORONARY CATHETERIZATION

Introduction: In recent years the trans-radial approach has been increasinglyemployed as an alternative approach to percutaneous coronary intervention. Loss of radial pulsemay lead to ischemic symptoms like pain in hand, claudication etc. There is a lack of local dataregarding complication associated with trans-radial coronary catheterization. Therefore, thereis need for local study to find out the frequency of complications associated with trans-radialapproach. Objectives: To determine the frequency of loss of radial pulse in patients undergoingtrans-radial coronary catheterization. Design: Cross sectional study. Setting: Department ofCardiology, Jinnah Hospital, Lahore. Period: From 3rd June 2014 to 2nd December 2014.Methodology: All 325 cases fulfilling the inclusion/exclusion criteria undergoing coronarycatheterization were included in the study. Results: A total of 325 patients, both male and femalewith positive Allens test, undergoing Trans-radial angiography for intervention were included.Loss of radial pulse was evaluated clinically at four weeks follow up.In our sampled population,mean age was 57.01 ± 6.8 years and 240 patients (73.8%) were male while 85 patients (26.2%)were female. Only 14 patients (4.3%) out of 325 had loss of radial artery pulse while remaining311 patients (95.7%) didn’t have loss of radial artery pulse. There was found no effect of genderon outcome i.e. loss of radial pulse but older age made a person prone to loss of radial pulse.Conclusion: It is concluded that the frequency (percentage) of loss of radial pulse is quite low(4.3%) in our patients undergoing trans-radial coronary catheterization.

FREQUENCY OF LOSS OF RADIAL PULSE IN PATIENTS UNDERGOING TRANSRADIAL CORONARY CATHETERIZATION

Introduction: In recent years the trans-radial approach has been increasinglyemployed as an alternative approach to percutaneous coronary intervention. Loss of radial pulsemay lead to ischemic symptoms like pain in hand, claudication etc. There is a lack of local dataregarding complication associated with trans-radial coronary catheterization. Therefore, thereis need for local study to find out the frequency of complications associated with trans-radialapproach. Objectives: To determine the frequency of loss of radial pulse in patients undergoingtrans-radial coronary catheterization. Design: Cross sectional study. Setting: Department ofCardiology, Jinnah Hospital, Lahore. Period: From 3rd June 2014 to 2nd December 2014.Methodology: All 325 cases fulfilling the inclusion/exclusion criteria undergoing coronarycatheterization were included in the study. Results: A total of 325 patients, both male and femalewith positive Allens test, undergoing Trans-radial angiography for intervention were included.Loss of radial pulse was evaluated clinically at four weeks follow up.In our sampled population,mean age was 57.01 ± 6.8 years and 240 patients (73.8%) were male while 85 patients (26.2%)were female. Only 14 patients (4.3%) out of 325 had loss of radial artery pulse while remaining311 patients (95.7%) didn’t have loss of radial artery pulse. There was found no effect of genderon outcome i.e. loss of radial pulse but older age made a person prone to loss of radial pulse.Conclusion: It is concluded that the frequency (percentage) of loss of radial pulse is quite low(4.3%) in our patients undergoing trans-radial coronary catheterization.

OPTIMAL TR-BAND WEANING STRATEGY WHILE MINIMIZING VASCULAR ACCESS SITE COMPLICATIONS

Transradial cardiac catheterization is increasing in the United States due to the advantages of less access site complications and patient preference. A compression device is most commonly used to achieve hemostasis following sheath removal, however the optimal weaning strategy to expedite TR-band

Abstract No. 419 Prone transradial catheterization for combined single-session endovascular and percutaneous interventions: approach, technical success, safety, and outcomes in 15 patients

Abstract No. 419 Prone transradial catheterization for combined single-session endovascular and percutaneous interventions: approach, technical success, safety, and outcomes in 15 patients

Oxidative stress and kidney injury in trans-radial catheterization.

Oxidative stress is linked to coronary artery disease and is a major mechanism in contrast-induced nephropathy. Trans-radial approach in coronary angiography (CA) with minimized peri-procedural bleeding is expected to reduce acute kidney injury incidence. In the present study, oxidative stress patterns observed in radial CA and their associations with early manifestations of kidney injury are described. A total of 20 stable coronary disease patients submitted to CA and 17 sex-matched patients undergoing computed tomography for myoskeletal reasons were enrolled. Reduced glutathione, catalase, thiobarbituric acid reactive species (TBARS) levels and total anti-oxidant status were measured at various time points postangiography. In ischemic patients baseline TBARS levels were 2-fold lower compared to controls, while carbonyls levels were 35% higher. Glutathione was almost 4-fold lower than the control group. Glutathione and lipid peroxidation in ischemic patients gradually increased after contrast medium administration and reached 180% (P<0.001) and 20% (P=0.021) after 4–6 h, respectively. Four patients presented early evidence of contrast-induced nephropathy postangiography, while no control patient developed acute kidney injury. In the multiple logistic regression analysis, only the creatinine levels at baseline influenced the frequency of early contrast-induced nephropathy development (β =0.36, 95% CI: 0.285–0.438, P=0.01). Glutathione low levels were dominant in the baseline values of ischemic patients who developed contrast-induced nephropathy. Glutathione levels rapidly increased while protein oxidation decreased at the expense of lipid peroxidation. In conclusion, early oxidative stress changes occur in trans-radial CA patients with a mild profile, sufficient to mobilize patient antioxidant defenses.

Heparin use for diagnostic cardiac catheterization with a radial artery approach: An international survey of practice patterns.

We aimed to describe global practice patterns of unfractionated heparin (UFH) use for diagnostic transradial cardiac catheterization. The use of the radial artery approach for cardiac catheterization is increasing globally. Limited contemporary data exist to support the use or optimal dosing of UFH to prevent radial artery occlusion (RAO) and other thromboembolic complications. We performed a web-based international survey of 450 interventional cardiologists from 34 countries. We collected information regarding the experience and use of UFH for diagnostic transradial cardiac catheterization. The survey was conducted between June and July 2016 and was completed by 227 (50.4%) interventional cardiologists. Overall, 83.3% performed >75% of their coronary angiograms via a radial approach, with the plurality (41.9%) having 10-20 years of clinical experience. Of all respondents, 7.5% did not use UFH for routine diagnostic transradial heart catheterization. Of the 92.5% who did use UFH, it was preferentially administered intra-arterially by 60% and intravenously by 40%. The majority (62.6%) of interventionalists used a fixed UFH dose with 5,000 IU being the most common dose (used in 48%). For those using a weight-based UFH (50 IU/kg) dosing regimen for diagnostic procedures (36.1%), the administered UFH dose ranged from 2,000 up to 10,000 IU. Despite the lack of firm evidence, the majority of interventional cardiologists who participated in the survey use UFH to prevent RAO for diagnostic transradial coronary angiography. However, there exist large practice disparities with regards to dose and route of administration. Given this knowledge gap, a dedicated randomized trial is warranted.

CRT-100.92 Radial Hemostasis Study: A Randomized Comparison of Safeguard Radial and TR Band on Radial Artery Occlusion

Asymptomatic radial artery occlusion (RAO) is a major limitation of transradial catheterization (TRC). Two radial compression hemostatic devices are compared for their effect on RAO. During 2016 in a prospective, randomized, single-center, blinded trial, 320 patients were randomly treated with a TR

Safety and efficacy of ulnar artery approach for percutaneous cardiac catheterization: Systematic review and meta-analysis.

Trans-radial access has rapidly become the standard for percutaneous coronary procedures in the last decade. As proceduralists overcome the learning curve and become more competent in trans-radial access, alternative safe access sites such as the ulnar artery have been increasingly used for emergent and elective procedures. The aim of this study was to synthesize the best available evidence of the impact on major adverse cardiac events (MACE) of ulnar artery compared to radial artery cardiac catheterization. This review considered randomized controlled trials that included adult patients who had a percutaneous coronary procedure via the radial or ulnar artery. The intervention of interest was the use of ulnar compared to radial artery for cardiac catheterization. An extensive search was undertaken for published and unpublished trials up to May 2017. Methodological quality was assessed independently by two reviewers using the Joanna Briggs Institute Meta-Analysis of Statistics Assessment and Review Instrument (JBI-MAStARI) checklist. Data were analyzed using Review Manager. A total of six trials were included in the review. There was no statistically significant difference in the incidence of MACE between patients who underwent trans-ulnar or trans-radial artery catheterization (OR 0.90; 95% CI 0.65-1.25). Complications associated with access including hematoma formation, (n = 6 trials) pseudo-aneurysm, and arterio-venous fistulae formation (n = 5 trials), were investigated in a total of 5,276 patients, with no difference in these complications noted between the two groups. There were no differences in arterial access time, fluoroscopy time, and contrast load between the two groups. There is evidence to support safe use of the ulnar artery as an alternative to the radial artery for access for cardiac catheterization.

Abstract TP367: Thrombolysis After Protamine Reversal Of Heparin For Acute Ischemic Stroke Post Cardiac Catheterization Case Report And Literature Review.

Introduction: Most acute ischemic stroke (AIS) patients post cardiac catheterization are excluded from intravenous thrombolysis therapy because of prolonged PTT from heparin during the procedure. The outcome of these patients are unfavorable with high mortality. Method: Case report and literature review. Results: An 87-year-old man with diabetes mellitus, hypertension, neurofibromatosis, and hyperlipidemia underwent an elective trans-radial cardiac catheterization for abnormal stress test evaluation. He had 2 drug-eluting stents for severe stenosis of mid circumflex and right coronary arteries. He received heparin 13,000 IU during procedure. He developed acute left hemiparesis with initial NIH stroke scale (NIHSS) of 4. CT brain and CT angiogram of head and neck were unremarkable. Bedside activated clotting time (ACT) was 181. Protamine 40 mg was administered and ACT levels were at 138 when it was repeated after 30 minutes.Intravenous tissue plasminogen activator (IV tPA) was administered at 4 hours 25 minutes from his last known well. Within 15 minutes, his NIHSS was 0. Brain MRI showed no acute infarction 24 hours post stroke. To our knowledge, Only 5 AIS cases post cardiac catheterization received protamine prior IV-tPA administration. Three cases received only 0.6 mg/kg of IV- tPA dose. The mean initial NIHSS was 10 (range: 4-16) and mean discharge NIHSS was 1 (range: 0-2). They all have favorable outcomes and no intracranial hemorrhage were reported. Conclusion: Protamine reversal of heparin for AIS post cardiac catheterization seems to be safe. Further studies are needed to confirm the therapeutic safety and efficacy of this strategy.

Radial artery pseudoaneurysm diagnosed by point-of-care ultrasound five days after transradial catheterization: A case report

Radial artery pseudoaneurysm diagnosed by point-of-care ultrasound five days after transradial catheterization: A case report

Initial Experience on Anatomical Snuff Box Approach for Coronary Angiogram &amp;amp; Percutaneous Coronary Intervention in a Tertiary Care Center Nepal

Introduction: Coronary Angiogram and Percutaneous Coronary Interventions are commonly performed via the femoral route. Then, transradial coronary catheterization became a popular & default technique due to less vascular access site complications and bleeding as compared to femoral route. Distal puncture of the radial artery through the anatomical snuff box access, however, has recently been shown potential benefit, like comfort to patients and operators, as well as maintenance of blood flow through the superficial palmar arch, in case of radial artery occlusion. Our aim was to evaluate the safety and feasibility of this new approach. Methods: A cross-sectional observational prospective study of patients underwent invasive diagnostic or therapeutic coronary procedures through the distal trans-radial access and traditional radial access. The primary endpoints were to access difficulties and in-hospital access-site related complications. Results: In 2 months, 190 patients underwent coronary procedures, of which 82 (43%) were selected in both distal transradial & traditional radial group. In 2(2.4%) & 3 (3.6%) cases, distal radial & traditional radial access cannulation was unsuccessful respectively (p >0.05). The mean age was 57.7 ± 10 & 57.2 ± 10 years in successful distal transradial & traditional radial cases respectively. There were no any major vascular complications in distal transradial group while there were 2 vascular complications in traditional radial group (p > 0.05). Conclusions: Distal transradial access is feasible and safe in selected cases, when performed by experienced operators. Larger case series and randomized trials are required to determine its efficacy in reducing vascular complications when comparing to the traditional technique.

Delayed Pseudoaneurysm after PCI Treated by Ultrasound-Guided Manual Radial Artery Compression: A Case Report

Although uncommon, radial artery access site complications are likely to become more frequent with the increased adoption of transradial cardiac catheterization, the incidence of radial artery pseudoaneurysm (PSA) has also increased. The treatments for radial artery PSA include ultrasound-guided radial artery compression, ultrasound-guided percutaneous thrombin injection, and surgical repair. This report is about a delayed radial artery PSA patient after percutaneous coronary intervention (PCI), treated by manual radial artery compression under the real-time monitoring of color Doppler ultrasound (CDU); the effect was significant.

Unusual complication of transradial intervention: Aleport

Transradial cardiac catheterization is frequently performed and is the preferred approach for coronary intervention over the last few years, mainly due to the dramatic decrease in access site complications, shorter hospital stay, and patient comfort. Radial artery pseudoaneurysm (RAP) following cardiac catheterization is an unusual, but serious complication which is rarely reported with very limited data on the clinical manifestations and management strategies. Although myriad noninvasive treatment options have surfaced in the recent years, surgical management remains the standard treatment for RAP. We herein describe a rare case of RAP following transradial access for coronary angiogram managed successfully by surgical resection of the pseudoaneurysm and radial artery ligation with complete alleviation of symptoms immediately postoperative and at follow-up.

Complications Following Transradial Cerebral Angiography : An Ultrasound Follow-Up Study.

ObjectiveThe feasibility and usefulness of transradial catheterization for coronary and neuro-intervention are well known. However, the anatomical change in the catheterized radial artery (RA) is not well understood. Herein, we present the results of ultrasonographic observation of the RA after routine transradial cerebral angiography (TRCA). MethodsPatients who underwent routine TRCA with pre- and post-procedure Doppler ultrasonography (DUS) of the catheterized RA were enrolled. We then recorded and retrospectively reviewed the diameter and any complicated features of the RA observed on DUS, and the factors associated with the diameter and complications were analyzed. ResultsA total of 223 TRCAs across 181 patients were enrolled in the current study. The mean RA diameter was 2.48 mm and was positively correlated with male gender (p<0.001) and hypertension (p<0.002). The median change in diameter after TRCA was less than 0.1 mm (range, -1.3 to 1.2 mm) and 90% of changes were between -0.8 and +0.7 mm. Across 228 procedures, there were 12 cases (5.3%) of intimal hyperplasia and 22 cases (9.6%) of asymptomatic local vascular complications found on DUS. Patients with abnormal findings on the first procedure had a smaller pre-procedural RA diameter than that of patients without findings (2.26 vs. 2.53 mm, p=0.0028). There was no significant difference in the incidence of abnormal findings for the first versus subsequent procedures (p=0.68). ConclusionDUS identified the pre- and post-procedural diameter and local complications of RA. Routine TRCA seems to be acceptable with regard to identifying local complications and changes in RA diameter.

The ACRA Anatomy Study (Assessment of Disability After Coronary Procedures Using Radial Access): A Comprehensive Anatomic and Functional Assessment of the Vasculature of the Hand and Relation to Outcome After Transradial Catheterization.

The palmar arches serve as the most important conduits for digital blood supply, and incompleteness may lead to digital ischemia when the radial artery becomes obstructed after cardiac catheterization. The rate of palmar arch incompleteness and the clinical consequences after transradial access are currently unknown. The vascular anatomy of the hand was documented by angiography in 234 patients undergoing transradial cardiac catheterization. In all patients, a preprocedural modified Allen test and Barbeau test were performed. Upper-extremity function was assessed at baseline and 2-year follow-up by the QuickDASH. Incompleteness of the superficial palmar arch (SPA) was present in 46%, the deep palmar arch was complete in all patients. Modified Allen test and Barbeau test results were associated with incompleteness of the SPA (P=0.001 and P=0.001). The modified Allen test had a 33% sensitivity and 86% specificity for SPA incompleteness with a cutoff value of >10 seconds and a 59% sensitivity and 60% specificity with a cutoff value of >5 seconds. The Barbeau test had a 7% sensitivity and 98% specificity for type D and a 21% sensitivity and 93% specificity for types C and D combined. Upper-extremity dysfunction was not associated with SPA incompleteness (P=0.77). Although incompleteness of the SPA is common, digital blood supply is always preserved by a complete deep palmar arch. Preprocedural patency tests have thus no added benefit to prevent ischemic complications of the hand. Finally, incompleteness of the SPA is not associated with a loss of upper-extremity function after transradial catheterization.

Endothelial Progenitor Cell Biology and Vascular Recovery Following Transradial Cardiac Catheterization.

BackgroundTransradial catheterization is associated with radial artery injury and vasomotor dysfunction and represents an accessible model of acute vascular injury in humans. We characterized vascular injury and functional recovery to understand the role of circulating endothelial progenitor cells in vascular repair.Methods and ResultsIn 50 patients (aged 64±10 years, 70% male) undergoing transradial cardiac catheterization, radial artery injury was assessed by optical coherence tomography and examination of explanted vascular sheaths. Flow‐ and nitrate‐mediated dilatation of the radial artery was assessed in both arms at baseline, at 24 hours, and at 1, 4, and 12 weeks. Circulating endothelial progenitor cell populations were quantified using flow cytometry. Late endothelial outgrowth colonies were isolated and examined in vitro. Optical coherence tomography identified macroscopic injury in 12 of 50 patients (24%), but endothelial cells (1.9±1.2×104 cells) were isolated from all arterial sheaths examined. Compared with the noncatheterized radial artery, flow‐mediated vasodilatation was impaired in the catheterized artery at 24 hours (9.9±4.6% versus 4.1±3.1%, P<0.0001) and recovered by 12 weeks (8.1±4.9% versus 10.1±4.9%, P=0.09). Although the number of CD133+ cells increased 24 hours after catheterization (P=0.02), the numbers of CD34+ cells and endothelial outgrowth colonies were unchanged. Migration of endothelial cells derived from endothelial outgrowth colonies correlated with arterial function before catheterization but was not related to recovery of function following injury.ConclusionsTransradial cardiac catheterization causes endothelial denudation, vascular injury, and vasomotor dysfunction that recover over 12 weeks. Recovery of vascular function does not appear to be dependent on the mobilization or function of endothelial progenitor cells.Clinical Trial Registration URL: https://www.clinicaltrials.gov. Unique identifier: NCT02147119.

Determinants of radiation dose during right transradial access: Insights from the RAD-MATRIX study

The RAD-MATRIX trial reported a large operator radiation exposure variability in right radial percutaneous coronary procedures. The reasons of these differences are not well understood. Our aim was to appraise the determinants of operator radiation exposure during coronary right transradial procedures. Patient arrangement during transradial intervention was investigated across operators involved in the RAD-MATRIX trial. Operator radiation exposure was analyzed according to the position of the patient right arm (close or far from the body) and in relation to the size of the upper leaded glass. Among the 14 operators who agreed to participate, there was a greater than 10-fold difference in radiation dose at thorax level (from 21.5 to 267 μSv) that persisted after normalization by dose-area product (from 0.35 to 3.5 μSv/Gy*cm2). Among the operators who positioned the instrumented right arm far from the body (110.4 μSv, interquartile range 71.5-146.5 μSv), thorax dose was greater than that in those who placed the instrumented arm close to the right leg (46.1 μSv, 31.3-56.8 μSv, P = .02). This difference persisted after normalization by dose-area product (P = .028). The use of a smaller full glass shield was also associated with a higher radiation exposure compared with a larger composite shield (147.5 and 60 μSv, respectively, P = .016). In the context of the biggest radiation study conducted in patients undergoing transradial catheterization, the instrumented right arm arrangement close to the leg and greater upper leaded shield dimensions were associated with a lower operator radiation exposure. Our findings emphasize the importance of implementing simple preventive measures to mitigate the extra risks of radiation exposure with right radial as compared with femoral access.

Radial artery occlusion after trans-radial catheterization – A clinic-doppler study: A single center experience

Radial artery occlusion after trans-radial catheterization – A clinic-doppler study: A single center experience