The Ispica fault is a NE-SW trending dextral transpression zone on the Hyblean Plateau in SE Sicily. Drag folds in Late Miocene to Pleistocene sediments within a narrow bend along the fault indicate neotectonic activity. The Ispica fault is part of a continental transform zone connecting the recent Pantelleria Rift system between Sicily and Tunisia with the eastern Sicilian active thrust belt (Gela Nappe). On the Hyblean foreland, regional fold- and thrust-planes in Upper Miocene-Pleistocene strata are parallel to the Ispica fault and reflect SE-NW directed maximum horizontal compression corresponding to the central Mediterranean stress regime. The contemporaneity of parallel strike-slip movements along the Ispica fault and the formation of regional parallel folds suggests decoupled wrenching for the Ispica fault.