Pneumatic transport of fine powders in fluidized dense-phase mode is becoming increasingly popular in various industries, such as power, chemical, cement, refinery, alumina, pharmaceutical, limestone, to list a few, because of the reasons of reduced gas flow rate and power consumption, decreased conveying velocities, improved product quality control, reduced pipeline sizing and wear rate, increased workplace safety etc. For the reliable design of a pneumatic conveying system, it is important to accurately predict the total pipeline pressure drop. However, accurate prediction of pressure drop from an improved understanding of the fundamental transport mechanism of fluidized dense-phase flow condition has only made limited progress till now because of the highly concentrated and turbulent nature of the gas-solids mixture. Power plant fly ash (median particle diameter: 30μm; particle density: 2300kg/m3; loose-poured bulk density: 700kg/m3) was conveyed through different pipelines (69mm I.D.×168m long; 105mm I.D.×168m long; 69mm I.D.×554m long). 8 different fly ash samples were tested in a fluidizing column for their deaeration characteristics and fluidized bulk densities were determined. Governing equations of flow for the dense-phase pneumatic conveying system of fine powders were solved using Runge-Kutta-Fehlberg (RKF45) method for different fluidized bulk densities of fly ash and air flow rates. The results have shown that the particle and actual gas velocities and the ratio of the two velocities increase in the direction of flow, while a reverse trend was apparent for the solids volumetric concentration. The results were compared against the predictions obtained using existing empirical relations for particle velocity. To develop an improved model for solids friction factor, an existing reliable pure dilute-phase model has been modified for dense-phase flow condition by incorporating sub-models for particle to actual gas velocity and impact and solids friction factor. The developed solids friction factor model was validated by using it to predict the total pipeline pressure drops for larger and longer pipelines and by comparing the experimental and predicted pneumatic conveying characteristics. The results have shown improved reliable predictions and that the model is capable of addressing the gradual transition of flow mechanism from dense- to dilute-phase. The accuracy of prediction is similar (in fact better in certain scale-up cases) when compared to a recently developed two-layer based model (developed by some of the authors). The results demonstrate the importance of incorporating particle and actual gas velocity terms in the model of solids friction factor instead of the prevailing techniques that overly depend on using superficial gas velocities.