Abstract The effects of iron ore mining carried out in the Southeast of Pará state, located in Northern Brazil, are present alongside the Estrada de Ferro Carajás (Carajás Railroad), especially in the city of São Luís do Maranhão, located in Northeastern Brazil, which is the port of export. Combined with the processes of mining, transport and exportation of the iron ore, infrastructure projects, factories, extensive cattle farming and monoculture, and lumber exploitation damage the landscape of the Eastern Amazon region and impair the local traditional way of life. Regarding the city of São Luís, such effects are more strongly felt in the rural zone, where they result in environmental conflicts. The present article discusses the relationship between the extended effects of mining and the backlash provoked by them in São Luís. Such a discussion comprises, among other subjects, the demands for Extractive Reserve, ways to guarantee the control over the territory, debates on urban legislation, opposition to the building of port terminals.