You have accessJournal of UrologyCME1 May 2022MP36-06 CHARACTERISTICS AND OUTCOMES OF DE NOVO PROSTATE CANCER IN THE SOLID ORGAN TRANSPLANT POPULATION AT THE UNIVERSITY OF MINNESOTA Brent Cleveland, Andrew Gardeck, Matthew Holten, Scott Jackson, Timothy Pruett, and Christopher Warlick Brent ClevelandBrent Cleveland More articles by this author , Andrew GardeckAndrew Gardeck More articles by this author , Matthew HoltenMatthew Holten More articles by this author , Scott JacksonScott Jackson More articles by this author , Timothy PruettTimothy Pruett More articles by this author , and Christopher WarlickChristopher Warlick More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002590.06AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Prior research suggests genitourinary malignancies occur at a higher incidence in solid organ transplant (SOT) population compared to the general population but the incidence of prostate cancer is not increased. Most studies examining prostate cancer in the transplant population consist of small cohorts and are limited to renal transplant recipients. We aim to expand our knowledge of the characteristics and outcomes of de novo prostate cancer diagnosed in a large single-center SOT cohort. METHODS: The University of Minnesota SOT database was queried for recipients who subsequently developed prostate cancer from 1984–2019. Available records were reviewed for clinical characteristics and outcomes. Descriptive statistics, frequencies, and Kaplan Meier survival estimates were calculated. RESULTS: Approximately 10,888 SOTs were performed during this timeframe. Of these, 139 had diagnosis code of prostate malignancy, of which 71 had confirmed diagnosis and available records. These men were predominantly Caucasian (94.4%) with a mean age at first transplant of 54.4 (±10.3) years and mean age at cancer diagnosis of 64.5 (±7.2) years. The most common transplant types were kidney (43.7%), heart (28.2%), and liver (14.1%). Median PSA at diagnosis was 7.2 ng/mL (range 1.1–91.3). Grade group 1 disease (32.4%) was most common at initial diagnosis, followed by groups 2 (23.9%) and 5 (14.1%). The distribution of initial treatments were: prostatectomy (38%), hormonal therapy (22.5%), surveillance (14.1%), radiation (8.5%), brachytherapy (4.2%), and cryotherapy (4.2%). At last known follow up, 25 patients had died (35.2%) with mean age of death of 72.4 (±7.1) years, mean time from transplant to death of 12.5 (±6.5) years, and mean overall survival after initial cancer diagnosis of 11.0 (±23.1) years. Two (2.8%) patients died from prostate cancer. Overall survival estimates at 5 and 10 years from initial cancer diagnosis were 82.4% and 56.5%, respectively. Prostate cancer specific survival was 96.2% at 5 and 10 years. CONCLUSIONS: This investigation of de novo prostate cancer in the largest single-center SOT cohort to date revealed clinical characteristics and survival in SOT recipients were similar to the non-transplant population for men diagnosed with localized disease. Source of Funding: None © 2022 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 207Issue Supplement 5May 2022Page: e598 Advertisement Copyright & Permissions© 2022 by American Urological Association Education and Research, Inc.MetricsAuthor Information Brent Cleveland More articles by this author Andrew Gardeck More articles by this author Matthew Holten More articles by this author Scott Jackson More articles by this author Timothy Pruett More articles by this author Christopher Warlick More articles by this author Expand All Advertisement PDF DownloadLoading ...