Based on the basic principle of the sandwich piezoelectric transducer, a high-power ultrasonic horn which can be used for viscosity reduction of heavy oil and pour point reduction of crude oil with high pour point was proposed and designed. The basic frequency of the horn is 16.8 kHz, and the input electrical power is 1 kw. It can work continuously on the industrial scale. First, the impedance characteristic was derived for the simplified model of the sandwich piezoelectric horn on the basis of equivalent network method. Second, its properties such as the resonance frequency, conductance, and transmitting voltage response were simulated by using of ANSYSsoftware in air, water, and silicone oil, respectively. According to the simulation, a prototype was made and measured by an impedance analyzer. Its basic frequency is in good agreement with the simulation calculation. The result shows that this high-power ultrasonic horn is expected to be applied on the industrial scale in viscosity reduction of heavy oil and ultrasonic sludge disintegration.