Disease Transmission Research Articles

Assessment of airborne infection control practices at health care facilities of Tumkur District, Karnataka: A descriptive study

IntroductionTuberculosis (TB) is a major health hazard in India and is one of the leading causes of death worldwide. Airborne transmission of infectious disease is a major public health concern. Adherence to the airborne infection control (AIC) is crucial to prevent spread of TB among patients who visit health care facilities and among the health care staff. ObjectivesTo assess the airborne infection control practices at health care facilities of Tumkur Methodology: This descriptive study was conducted in 85 public health institutes in 5 TB units of Tumkur. Data was collected using pre-tested; semi-structured questionnaire through personal interview, verification of records and inspection using WHO check-list. ResultsThe present study showed infection control committee and infection control plan were present in 97.65% and 90.59%, clinical staff underwent periodic TBIC training in 91.76% of PHIs. Waiting area and sputum sample collection area were well-ventilated in 97.65% & 97.65% of PHIs. Health workers practiced hand hygiene in 90.59%, PPEs were available in 85.06% PHIs. ConclusionThe study concludes that, airborne infection control measures which includes administrative, environmental, and use of personal protective equipment were satisfactory among the PHIs but still there is scope for improvement.

A comprehensive analysis of removal of hazardous dust particulates from chemical and process industries off gases by advanced wet scrubbing techniques – A review

The entire globe has been suffering from the hazardous effects of air pollution since the last century. Particulate matter (PM), being one of the primary concerns of atmospheric hazard, leads to several acute and chronic health hazards of present times. This specific research briefs us about the wide spread PM health impacts, sources of particulate nuisance, some specific control measures, and their advancement over the years. It has been observed recently that the rising concern of world population, global urbanization, and artificial intervention are the prime causes of air pollution. The immediate effects of such PM lead to an overall increased rate of mortality and morbidity in the human race. The rate of transmission of several airborne diseases through the atmospheric medium in form of droplet-aerosol imposes severe threat over the deep respiratory organs of several lifeforms. The study portrays vast characterization cum classification of several wet scrubbing techniques used till date. There is a clear comparison between conventional and modified treatment options for handling PM in an efficient manner. Since huge amount of mass transfer phenomena has been conducted for the efficient removal of PM via various modes of wet scrubbers, it was quite necessary to focus on the extensive literature related to such novel technologies. Numerous associated techniques can be clubbed in assembly with the available conventional system which works best in modified variants as proposed research. Moreover, zero discharge, environmental sustainability, and cost effectiveness can be taken into account for achieving the best outcomes.

Association between air pollution, meteorological factors and hand, foot, and mouth disease incidence in Zhejiang Province: A Bayesian spatio-temporal modelling study

Temperature and humidity are known to influence seasonal patterns of hand, foot and mouth disease (HFMD) transmission. However, the effect of air pollution and climate-air pollution interaction on the intensity of HFMD epidemics is poorly understood. This study aims to quantify the exposure-response effects of air pollution on HFMD risk by level of meteorological indicators in Zhejiang Province. A spatiotemporal Bayesian hierarchical model was used to determine the exposure-response association between air pollution, meteorological factors and the relative risk (RR) of HFMD. The model was fitted to monthly HFMD case data for the 92 counties in Zhejiang Province between January 2013, and December 2021. We assessed both linear interaction effects between air pollutants and meteorological factors on HFMD, and the modification role of extreme weather conditions on the nonlinear air pollutant-HFMD association. A 10 μg/m³ increase in PM10 and NO2 concentration raised the HFMD risk by 6.6% (RR = 1.066, 95% CI: 1.042, 1.092) and 20.8% (RR = 1.208, 95% CI: 1.162, 1.256) respectively. HFMD was negatively associated with O3 (RR = 0.980, 95% CI: 0.968, 0.993), SO2 (RR = 0.820, 95% CI: 0.776, 0.868) and CO (RR = 0.770, 95% CI: 0.621, 0.956). Temperature, humidity, and precipitation positively interacted with most air pollutants on HFMD, while wind speed had a negative interaction effect. In higher temperature conditions, the HFMD risk associated with PM10 increased. Elevated humidity levels amplified the risk associated with PM10, as did CO concentrations within a certain range. Heavy rainfall intensified the risk of HFMD associated with PM10, SO2, and CO. Results of this study showed that air pollution was associated with HFMD incidence, with different climate factors playing various modification roles in the associations and primarily leading to increased risk under extreme conditions. These findings provide a theoretical basis for personal protection and government prevention and control measures.

Characterization of Entamoeba fatty acid elongases; validation as targets and provision of promising leads for new drugs against amebiasis.

Entamoeba histolytica is a protozoan parasite belonging to the phylum Amoebozoa that causes amebiasis, a global public health problem. E. histolytica alternates its form between a proliferative trophozoite and a dormant cyst. Trophozoite proliferation is closely associated with amebiasis symptoms and pathogenesis whereas cysts transmit the disease. Drugs are available for clinical use; however, they have issues of adverse effects and dual targeting of disease symptoms and transmission remains to be improved. Development of new drugs is therefore urgently needed. An untargeted lipidomics analysis recently revealed structural uniqueness of the Entamoeba lipidome at different stages of the parasite's life cycle involving very long (26-30 carbons) and/or medium (8-12 carbons) acyl chains linked to glycerophospholipids and sphingolipids. Here, we investigated the physiology of this unique acyl chain diversity in Entamoeba, a non-photosynthetic protist. We characterized E. histolytica fatty acid elongases (EhFAEs), which are typically components of the fatty acid elongation cycle of photosynthetic protists and plants. An approach combining genetics and lipidomics revealed that EhFAEs are involved in the production of medium and very long acyl chains in E. histolytica. This approach also showed that the K3 group herbicides, flufenacet, cafenstrole, and fenoxasulfone, inhibited the production of very long acyl chains, thereby impairing Entamoeba trophozoite proliferation and cyst formation. Importantly, none of these three compounds showed toxicity to a human cell line; therefore, EhFAEs are reasonable targets for developing new anti-amebiasis drugs and these compounds are promising leads for such drugs. Interestingly, in the Amoebazoan lineage, gain and loss of the genes encoding two different types of fatty acid elongase have occurred during evolution, which may be relevant to parasite adaptation. Acyl chain diversity in lipids is therefore a unique and indispensable feature for parasitic adaptation of Entamoeba.

Development and validation of a predictive scoring model for risk stratification of tuberculosis treatment interruption

BackgroundTuberculosis (TB) treatment interruption poses risks of antimicrobial resistance, potentially leading to treatment failure and mortality. Addressing the risk of early treatment interruption is crucial in tuberculosis care and management to improve treatment outcomes and curb disease transmission. ObjectivesThis study aimed to identify risk factors of TB treatment interruption and construct a predictive scoring model that enables objective risk stratification for better prediction of treatment interruption. MethodsA multicentre retrospective cohort study was conducted at public health clinics in xxx over 11 months from March 2022 to January 2023, involving adult patients aged ≥18 years with drug-susceptible TB diagnosed between 2018 to 2021. Cumulative missed doses or discontinuation of TB medications for ≥ 2 weeks, either consecutive or non-consecutive, was considered as treatment interruption. The model was developed and internally validated using the split-sample method. Multiple logistic regression analysed 18 pre-defined variables to identify the predictors of TB treatment interruption. The Hosmer-Lemeshow test and area under the receiver operating characteristic curve (AUC) were employed to evaluate model performance. ResultsOf 2953 cases, two-thirds (1969) were assigned to the derivation cohort, and one-third (984) formed the validation cohort. Positive predictors included smoking, previously treated cases, and adverse drug reactions, while concurrent diabetes was protective. Based on the validation dataset, the model demonstrated good calibration (P = 0.143) with acceptable discriminative ability (AUC = 0.775). A cutoff score of 2.5 out of 11 achieved a sensitivity of 81% and a specificity of 64.4%. Risk stratification into low (0-2), medium (3-5), and high-risk (≥6) categories showed ascending interruption rates of 5.3%, 18.1%, and 41.3%, respectively (P < 0.001). ConclusionThe predictive scoring model aids in risk assessment for TB treatment interruption, enabling focused monitoring and personalized intervention plans for higher-risk groups in the early treatment phase.

Occurrence and source identification of the disinfectant didecyldimethylammonium chloride in a Japanese watershed receiving effluent from swine farms

Didecyldimethylammonium chloride (DDAC), a toxic quaternary ammonium compound (QAC) linked to multidrug resistance, is used widely in households and hospitals and on swine farms to prevent disease transmission. However, little is known about its occurrence in watersheds receiving livestock wastewaters or manure. We monitored DDAC and tracers (veterinary and human drugs) once a season over a year at 14 sites in a Japanese watershed where swine outnumbered humans 1.2 to 1 and where both swine and human wastewaters were largely treated on site. DDAC concentrations in sewage-treatment-plant effluent (33–52 ng/L) were close to, whereas those in river waters (3.6–16,672 ng/L) far exceeded, those reported worldwide. DDAC mass flows at the catchment outlet (1692–3816 μg/s) were higher than those of any of the drugs. DDAC concentrations were significantly correlated with total concentrations of veterinary drugs (Spearman's correlation coefficient, 0.95, P < 0.01), indicating that the major pathway of DDAC entry to surface waters was via effluent discharge from swine farms. Comparison of observed and predicted mass flows implied that a substantial percentage of DDAC was washed from the barn floor into swine excrement. To our knowledge, this is the first study to demonstrate QAC hotspots attributable to animal husbandry.

GIS-ODE: linking dynamic population models with GIS to predict pathogen vector abundance across a country under climate change scenarios.

Mechanistic mathematical models such as ordinary differential equations (ODEs) have a long history for their use in describing population dynamics and determining estimates of key parameters that summarize the potential growth or decline of a population over time. More recently, geographic information systems (GIS) have become important tools to provide a visual representation of statistically determined parameters and environmental features over space. Here, we combine these tools to form a 'GIS-ODE' approach to generate spatiotemporal maps predicting how projected changes in thermal climate may affect population densities and, uniquely, population dynamics of Ixodes ricinus, an important tick vector of several human pathogens. Assuming habitat and host densities are not greatly affected by climate warming, the GIS-ODE model predicted that, even under the lowest projected temperature increase, I. ricinus nymph densities could increase by 26-99% in Scotland, depending on the habitat and climate of the location. Our GIS-ODE model provides the vector-borne disease research community with a framework option to produce predictive, spatially explicit risk maps based on a mechanistic understanding of vector and vector-borne disease transmission dynamics.

Buruli ulcer, tuberculosis and leprosy: Exploring the One Health dimensions of three most prevalent mycobacterial diseases: A narrative review.

The literature review was conducted using the online databases PubMed, Scopus, ProQuest and Google Scholar, reviewing articles that were written in English in the last 15 years. Grey literature, published by intergovernmental agencies, was also reviewed. For the pathogen of Buruli ulcer, evidence suggests possums as a possible animal reservoir and thus having an active role in disease transmission to humans. Cattle and some wildlife species are deemed as established animal reservoirs for tuberculosis pathogens, with a non-negligible proportion of infections in humans being of zoonotic origin. Armadillos constitute an established animal reservoir for leprosy pathogens with the transmission of the disease from armadillos to humans being deemed possible. Lentic environments, soil and other aquatic sources may represent further abiotic reservoirs for viable Buruli ulcer and leprosy pathogens infecting humans. Ongoing investigation and implementation of public health measures, targeting (sapro)zoonotic transmission can be found in all three diseases. Buruli ulcer, tuberculosis and leprosy exhibit important yet still poorly understood One Health aspects. Despite the microbiological affinity of the respective causative mycobacteria, considerable differences in their animal reservoirs, potential environmental sources and modes of zoonotic transmission are being observed. Whether these differences reflect actual variations between these diseases or rather knowledge gaps remains unclear. For improved disease control, further investigation of zoonotic aspects of all three diseases and formulation of One Health relevant interventions is urgently needed.

Investigation of the distribution and origin of porcine reproductive and respiratory syndrome virus 1 in the swine production chain: A retrospective study of three farms in Thailand

Background and Aim: Porcine reproductive and respiratory syndrome (PRRS), caused by PRRS virus (PRRSV), is a global issue that affects Thai swine as well. In Thailand, PRRSV-2 predominates over PRRSV-1. The origin of PRRSV-1 transmission remains undiscovered. This study traced the source of infected pigs responsible for disease transmission among three pig-fattening farms and analyzed the spread of PRRSV-1. Materials and Methods: A total of 696 swine samples from breeding and pig-fattening farms in Thailand were screened for PRRSV using open reading frames (ORF7) reverse transcription polymerase chain reaction (RT-PCR). Positive samples were identified as PRRSV-1 using ORF5 RT-PCR. The analysis included the study of nucleotide homology, GP5 amino acid sequences, and N-linked glycosylation patterns to assess the spread of PRRSV-1 across these farms. Results: Genetic examination identified 28 PRRSV-1-positive samples, of which 13 were chosen as representatives. These strains were categorized into three groups based on breeding farm pig houses and showed distinct distribution patterns across pig-fattening farms. Group 1 included piglets transferred from pig house A to Nakhon Pathom, Chonburi, and Sa Kaeo. Groups 2 and 3 showed transfers from pig houses F and H to Chonburi and Sa Kaeo farms. All 13 PRRSV-1 strains were categorized into PRRSV-1 subtype 1/clade H. N-linked glycosylation analysis revealed that nearly all PRRSV-1 strains exhibited a conserved glycosylation pattern at amino acid positions N37, N46, and N53. This pattern is consistent with the glycosylation profile of the previous Thai PRRSV-1 subtype 1/clade H. Conclusion: The present study highlights the persistent presence of PRRSV-1 in Thai swine, which leads to sporadic outbreaks. The molecular genetic analysis identified three primary strain groups dispersed throughout the pig production system, emphasizing the importance of regular monitoring for new PRRSV strains in this herd. Understanding the PRRSV-1 distribution in swine farms is vital for veterinarians. This knowledge supports strategies for eradicating the virus and managing swine health effectively in Thailand. Keywords: porcine reproductive and respiratory syndrome virus-1, swine production system, Thailand, virus distribution.

Leveraging and learning from the long COVID experience: Translating telerehabilitation into practice.

Telerehabilitation, or the delivery of rehabilitation services through telehealth platforms, has existed since the late 1990 s. Telerehabilitation was characterized by unprecedented, exponential growth at the beginning of the novel coronavirus-2019 (COVID-19) pandemic. Medical systems sought to reduce the likelihood of disease transmission by using telerehabilitation to limit physical proximity during routine care. This dramatic change in how medical care was delivered forced many professions to adapt processes and practices. Following the change, debates sparked regarding the best path to move forward for the betterment of patients, clinicians, systems, and society. Long COVID has emerged as a complex chronic health condition arising from COVID-19. The unique needs and dynamic disease process of Long COVID has incentivized medical systems to create equitable ways for patients to safely access interdisciplinary care. The purpose of this commentary is to describe what medical systems must consider when deploying high-quality telerehabilitation to deliver rehabilitation through asynchronous (e.g., text, portal) and synchronous modalities (e.g., phone or video). We highlight lessons learned to help guide decision-makers on key actions to support their patients and clinicians. Not applicable. Not applicable. Key action steps from our lessons learned may be used to address complex chronic health conditions such as Long COVID and prepare for future challenges that may disrupt medical systems.

20 years on from the Dublin Declaration: European Committee for the Prevention of Torture and Inhuman or Degrading Treatment reporting on the provision of prison needle and syringe programmes in the Council of Europe region.

BackgroundPrisons in Europe remain high-risk environments and conducive for infectious disease transmission, often related to injection drug use. Many infected people living in prison unaware of their infection status (HIV, hepatitis C). Despite all Council of Europe (CoE) member states providing community needle and syringe programmes (NSP), prison NSP are limited to seven countries. The study aim was to scrutinise the Committee for the Prevention of Torture and Inhuman or Degrading Treatment (CPT) reporting of periodic and ad hoc country mission visits to prisons, with an explicit focus on the extent to which member states are/were fulfilling obligations to protect prisoners from HIV/hepatitis C; and implementing prison NSP under the non-discriminatory equivalence of care principle. Study DesignSocio-legal review. MethodsA systematic search of the CPT database was conducted in 2024 with no date restriction. All CPT reports were screened in chronological order with the terms; “needle”, “syringe”, “harm reduction” and “NSP”. Relevant narrative content on prison NSP operations, including repeat CPT reminders and any official/publicly expressed reasons for not implementing is presented. ResultsCPT reporting reveals limited prison NSP provision in selected prisons visited on mission, with little change in status over time, despite documented evidence of prior observations around absent/insufficient harm reduction measures and explicit (often longstanding) recommendations to address deficits. Reasons for not implementing prison NSP include; existing availability of opioid substitute treatment, lack of evidence for injecting drug use, for security and maintenance of order, and contradiction with prison protocols sanctioning drug use. ConclusionsPrison health is public health. Regular research and evaluations of prison NSP in Europe are warranted. Future CPT visits should also continue to assess availability and standards of provision; recommend where appropriate including when opioid substitute treatment is already provided, and in line with broad availability of community NSP in Europe.

Prevalence data on chicken diseases in low-resource settings.

The presence of transmissible disease in livestock has a major impact on welfare and economics in animal and public health. A lack of data enables the spread of diseases due to misinformed decision-making on prevention and control. Low-resource settings face challenges in providing data, turning data availability into a development issue. For this study, a large dataset (n = 997) was collected on prevalence and seroprevalence estimates on viral (n = 224), bacterial (n = 83) and parasitic (n = 690) diseases in backyard chickens in low- and middle-income countries (LMICs). These estimates originate from 306 studies identified during the screening phase of a systematic literature review. An attempt was made to classify the studies according to the Food and Agriculture Organization of the United Nations'classification system for family poultry production systems. Of the studies, 98.7% (302/306) focused on a single poultry production system, while 1.3% (4/306) targeted two different production systems. Within the group of studies that covered one production system, 85.4% (258/302) were classified as ‘small extensive scavenging or extensive scavenging,'‘small extensive scavenging'and/or ‘extensive scavenging'. In addition, 52% (159/306) of the studies did not report information on chicken breed type. No data were found on any relevant disease for 56.9% (78/137) of LMICs, signifying a potential data gap. Of the estimates on viral and bacterial diseases, 71.0% (218/307) corresponded to diseases notifiable to the World Organisation for Animal Health, highlighting a tendency to measure disease occurrence for diseases relevant to trade. The latter might not necessarily be priority diseases for the producers, however. Furthermore, 72.3% (222/307) of the estimates originate from random samples and could be used to estimate prevalence in backyard chickens using imputation methods, thus bridging the data gap.

Re-Emerging, Under-Recognized Zoonotic, and Neglected Tropical Diseases in Hawai'i.

Hawai'i, the United States' most western geographic state in the Pacific, lies between the North and South American continents and the Indo-Pacific regions, including Japan. The tropical environmental conditions of the Hawaiian Islands provide favorable ecosystems for various infectious pathogens, their vectors, and reservoirs. This creates an environment conducive to the transmission of zoonotic diseases affecting both humans and animals. Hawai'i has experienced an increase in dengue, leptospirosis, and murine typhus outbreaks. Furthermore, toxoplasmosis and neuroangiostrongyliasis cases remain prevalent throughout the state, and the putative presence of autochthonous Zika cases identified in a retrospective study may be of national public health concern. Understanding the factors that affect the transmission and distribution of zoonoses is necessary to identify at-risk locations and populations. The One Health approach seeks to understand, report, and interpret these factors and requires collaboration between private and governmental institutions. One Health should focus on neglected tropical diseases (NTD) and prioritize development of interventions to control and prevent the transmission of diseases that spread between animals and humans. This review focuses on the epidemiological and clinical characteristics of under-recognized zoonotic and NTD affecting Hawai'i, including leptospirosis, murine typhus, neuroangiostrongyliasis, toxoplasmosis, dengue, and Zika.

Mathematical Analysis and Numerical Simulation on Free-Living Leptospira: A Mathematical Modeling Perspective

A bacterial disease called leptospirosis is very typical in both tropical and subtropical regions. It is a well-known animal-borne illness that is brought on by spiral-shaped bacteria (Leptospira spp.). Both directly and indirectly, the disease can spread to humans through the urine of sick animals or polluted water, soil, or food. Two phases might appear in leptospirosis symptoms. The patient will have symptoms such as fever, chills, headache, muscle aches, vomiting, or diarrhea during the first phase, which is known as the Septicemic phase. In the meantime, the Immune phase, the second, is more severe. Meningitis, liver failure, renal failure, or both could be fatal for the patient. This study aimed to create a mathematical model of leptospirosis disease using free-living bacteria. In the model, interactions occur between people, free-living Leptospira, animal hosts, and animal vectors. The population's characteristics are used to build the model, and the actual issue is used to identify the disease's transmission paths. While the endemic equilibrium is investigated numerically, the disease-free equilibrium is analyzed theoretically. The paper demonstrates that for the established mathematical model with an epidemic threshold $R_0$, analytical and numerical solutions produced the same outcome.

Analysis of Dynamics of a Recurrent Infectious Disease SIRS Model with Age Structure and Two Delays

In this paper, an SIRS model with age structure is proposed for recurrent infectious diseases by incorporating infectious delay and temporary immunity delay. Analysis shows that the disease will eventually disappear when the basic reproduction number [Formula: see text]. No matter how the infection delay [Formula: see text] changes, as long as the temporary immunity loss delay [Formula: see text], the disease transmission will only be endemic and there will be no periodic oscillations when [Formula: see text]. Moreover, the stability and Hopf bifurcation will appear as [Formula: see text] increases from zero. It indicates that the duration of temporary immunity can affect the form of disease transmission within the population. Our numerical simulations verified the correctness of the theoretical results.

STABILITY OF THE DYNAMIC MODEL OF SVPR SEXUAL VIOLENCE CASES

In this study, the stability of the equilibrium points of the Susceptible Violent Punishment Recovered (SVPR) model in the spread of sexual violence cases is analyzed. The model assumes that sexual violence can spread similarly to the transmission of infectious diseases. The constructed model is a system of nonlinear differential equations. The model has two equilibrium points: the equilibrium point with sexual violence-free and the endemic equilibrium point with sexual violence. Stability analysis is then carried out for both fixed points, indicating that the violence-free equilibrium is asymptotically stable if the basic reproduction number . Meanwhile, the endemic equilibrium is asymptotically stable if the condition and four other conditions are satisfied. Numerical simulations are required to observe the implementation of the model using MAPLE software. As for this research, we conclude a model that shows the spread of sexual violence is not widespread because it was found that .

A Systematic Review of Muslim Women’s Knowledge, Perception and View Toward Breast Milk Donation and Milk Bank

Background: Prematurely born, low birth weight, or sick infants are vulnerable and often do not receive enough breast milk from their mothers. In such cases, donated breast milk from other mothers can be safely stored in a milk bank. However, some Muslim countries have been hesitant to establish milk banks due to religious and ethical concerns. Despite this, a few Muslim nations have established Muslim-friendly milk banks to meet the increasing demand for donated breast milk. Nonetheless, it is unclear whether the Muslim community will fully embrace these efforts. This systematic review aims to gather and appraise evidence on Muslim knowledge, perceptions, and views towards breast milk donation and establishing Muslim-friendly milk banks. Methods: A systematic search was conducted in Wiley Online Library, Scopus, Science Direct, ProQuest, and EBSCOhost databases using specific search terms and keywords. The search aimed to identify articles published between 2016 and November 2023 that discuss Muslim knowledge, perceptions, and views regarding breastmilk donation, as well as the establishment of Muslim-friendly milk banks. The identified articles were then screened and retrieved. Results: A total of 2498 articles were initially retrieved out of which only twelve studies met the inclusion criteria and were finally considered for analysis. All the studies were conducted in Middle East countries among Muslim women. The analysis revealed that the majority of Muslim women were not aware of the availability of Muslim-friendly milk banks. They showed reluctance in donating their breast milk due to religious concerns. Moreover, a significant proportion of women expressed their doubts about the endorsement of milk banking due to religious beliefs and concerns regarding the potential transmission of diseases. Conclusion: Recent studies have shown that there is a lack of awareness regarding Muslim-friendly milk banks, and there are also negative perceptions and views about donating breast milk and setting up milk banks. It is important to provide information that can increase women’s confidence and encourage them to participate in breast milk donation and milk bank utilisation.

Strongyloides stercoralis infection in solid organ transplant recipients.

Strongyloides stercoralis infection remains of concern due to its high associated morbidity among solid organ transplant recipients (SOTR) and the risk of donor-derived infection (DDI). We review key aspects of epidemiology to inform screening for and treatment of chronic infection among organ transplant candidates to reduce the risk of infectious complications in the posttransplant setting. In this work, we offer guidance regarding the optimal management of Strongyloides hyperinfection syndrome and disseminated infection and offer recommendations regarding posttreatment surveillance and the potential need for repeat treatment during subsequent periods of augmented immunosuppression. This review also provides updated recommendations for screening of deceased and living donors as recently proposed by the Organ Procurement and Transplantation Network's Ad Hoc Disease Transmission Advisory Committee. Risk reduction of Strongyloides infection in the SOTR population can be further enhanced by optimized treatment of infection, posttreatment surveillance during at-risk periods and recent proposed policy shifts to universal donor screening.

Assessment of knowledge, attitude, and practice of solid waste management system among households of Darge sub-city, east Wollega Zone, Oromia, Western Ethiopia

Background: Inappropriate solid waste management produced in the course of human activities has serious problems for the environment that adversely affect the health of the human population. Thus, towns and cities in developing countries like Ethiopia face environmental health and aesthetic problems resulting from improper management of solid waste disposal. Uncontrolled waste management may also contribute to the transmission of communicable diseases from different systems as well as encourage fly breading, which has nuisance effects in addition to disease transmission. Objective: To assess knowledge, attitude, and practice of solid waste management systems in households in Darge sub-city, East Wollega Zone, Oromia, Ethiopia. Methods: A community-based cross-sectional study was conducted using systematic random sampling techniques from February 1st to February 15th, 2022. Data was collected from 278 households using a structured interviewer-administered questionnaire. After data collection, data analysis was performed using SPSS computer software version 22.0. Results: The study showed that 67.3% had good knowledge, 65.86% had a positive attitude, and 63.3% had good practice in solid waste management (SWM). Among the households, 12.6% and 42.1% dispose of solid waste in open fields and open disposal pits, respectively. The perceived reason for improper solid waste disposal was a lack of awareness (55.4%) and a shortage of a place for solid waste disposal (30.6%). Conclusion: The knowledge, attitude, and practice of households in the study area need improvement according to standards for towns and sub-cities. Increasing knowledge, changing attitudes, and improving practice in SWM using the existing structure are recommended.

Developing an SEIHR epidemiological model featuring saturated incidence rate and investigating its stability

Each and every person will inevitably come into contact with infectious diseases over their lifetime. This unavoidable phenomena is a characteristic of all people. Ideally, the effects of such diseases are still controllable, but under unfavourable circumstances, they may worsen and become full-fledged outbreaks. As a result, this article tries to offer an SEIHR model whose main goal is to reduce and stop the transmission of infectious diseases. Notably, infectious diseases continue to plague many countries, represented by the global threat of Covid-19, underlining the urgent need for efficient control methods. This model stands out because it carefully takes into account the saturated incidence rate of infectivity. The concept also divides the infected population into two different groups, enabling more focused and customized medical interventions. The article begins by closely examining the positivity and boundedness of the model, then conducts a thorough analysis of the fundamental reproductive number. The model's stability is then categorically proven at both equilibrium points. In summary, the article concludes with convincing numerical simulations that validate the suggested model, providing convincing evidence of its effectiveness as a whole. In conclusion, the suggested SEIHR model, which is supported by a wealth of empirical evidence confirming its efficacy and optimality, represents a significant advancement in the management and containment of infectious diseases. It offers a promising route for addressing the enduring threat of infectious diseases on a global scale, and its unique form and extensive analysis highlight its potential to alter our approach to infectious disease control.