Translation Experiments Research Articles

Effects of Adopting Preventive Drug Lists on Medication Costs and Disparities by Income Over 2 Years: A Natural Experiment for Translation in Diabetes (NEXT-D) Study.

To examine the association between preventive drug lists (PDLs) and changes in medication costs among patients with diabetes insured in commercial health plans over 2 follow-up years. We conducted a quasiexperimental study using the Optum deidentified Clinformatics Data Mart Database (January 2003 to December 2017). The intervention group included 5,582 patients with diabetes age 12-64 years switched by employers to PDL coverage; the control group included 5,582 matched patients whose employers offered no PDL. Outcomes included out-of-pocket costs, standardized costs, and 30-day fills for all medications because PDL-associated savings could be used to pay for medicines in other classes and for five therapeutic classes covered by the PDLs (oral diabetic medications, insulins, test strips, antihypertensive drugs, and lipid-lowering drugs). Pre- to post-out-of-pocket spending for all medications declined by 29.7% in follow-up year 2 (95% CI -36.0, -23.4%) among PDL members relative to controls. Higher-income and lower-income PDL members experienced significant reductions in out-of-pocket spending for all medications in year 2 (30%) and for key therapeutic classes (range -23 to -67%). We found significant increases in use of key therapeutic classes in the overall population (range 8-15%) and in higher-income and lower-income PDL members (range 9-50%). PDLs offer an effective strategy for employers and insurers to lower member cost sharing and encourage increased use of important medications to prevent or manage chronic illnesses. For patients with diabetes, especially those with lower incomes, PDL coverage resulted in substantial and persistent reductions in out-of-pocket medication costs, medication use increases, and some increased use of more expensive products.

Machine Translation-Friendly Language for Improved Machine Translation Output in Academic Writing

Academic writing aims to disseminate scholarly knowledge to a target audience in concise language. During this process, translators sometimes translate academic texts into foreign languages, so that the output of scholarly research can be read by speakers of different languages. In such cases, translators are to translate the source text into the target language in a clear and comprehensible language. This paper discusses how the authors of scholarly texts can structure their writing properly, so that they can help translators compose clear and concise translation output. Although the knowledge and skills of the translator are a key consideration in ensuring the quality of translated texts, the source text itself is highly influential in the quality of the output. Furthermore, although they might partially differ from one language to another, academic writing has some well-established conventions. Therefore, translators might experience some problems when they translate scholarly texts. This study aims to pinpoint such issues and to offer viable strategies that could be used for solving them before the translation process. Commonly encountered problems that impair the quality of the translation output are as follows: wordiness, ambiguous expressions, failing to consider the discourse structure of the target language while organising the source text, using conjunctions carelessly, using the passive voice unnecessarily, using indirect language to express ideas, using synonymous words sequentially, typos, and other similar problems. Though experience in academic translation can help solve some of these issues, it might not be possible to produce good translation output if the source text is poorly written. Success in academic translation can be achieved through collaboration between the author of an academic text and its translator. For this reason, it is necessary to raise the awareness of writers and translators on this issue.

Evolving Escherichia coli to use a tRNA with a non-canonical fold as an adaptor of the genetic code.

All known bacterial tRNAs adopt the canonical cloverleaf 2D and L-shaped 3D structures. We aimed to explore whether alternative tRNA structures could be introduced in bacterial translation. To this end, we crafted a vitamin-based genetic system to evolve Escherichia coli toward activity of structurally non-canonical tRNAs. The system reliably couples (escape frequency<10-12) growth with the activities of a novel orthogonal histidine suppressor tRNA (HisTUAC) and of the cognate ARS (HisS) via suppression of a GTA valine codon in the mRNA of an enzyme in thiamine biosynthesis (ThiN). Suppression results in the introduction of an essential histidine and thereby confers thiamine prototrophy. We then replaced HisTUAC in the system with non-canonical suppressor tRNAs and selected for growth. A strain evolved to utilize mini HisT, a tRNA lacking the D-arm, and we identified the responsible mutation in an RNase gene (pnp) involved in tRNA degradation. This indicated that HisS, the ribosome, and EF-Tu accept mini HisT ab initio, which we confirmed genetically and through in vitro translation experiments. Our results reveal a previously unknown flexibility of the bacterial translation machinery for the accepted fold of the adaptor of the genetic code and demonstrate the power of the vitamin-based suppression system.

Efficient generation of human immune system rats using human CD34+ cells

Human immune system (HIS) mice generated using human CD34+ hematopoietic stem cells serve as a pivotal model for the invivo evaluation of immunotherapies for humans. Yet, HIS mice possess certain limitations. Rats, due to their size and comprehensive immune system, hold promise for translational experiments. Here, we describe an efficacious method for long-term immune humanization, through intrahepatic injection of hCD34+ cells in newborn immunodeficient rats expressing human SIRPα. In contrast to HIS mice and similar to humans, HIS rats showed in blood a predominance of Tcells, followed by B cells. Immune humanization was also high in central and secondary lymphoid organs. HIS rats treated with the anti-human CD3 antibody were depleted of human Tcells, and human cytokines were detected in sera. We describe for the first time a method to efficiently generate HIS rats. HIS rats have the potential to be a useful model for translational immunology.

Drug Delivery Systems for Natural Medicines in Cancer Therapy.

Cancer stands as a prominent global cause of mortality, with chemotherapy using synthetic drugs being the predominant treatment method. Despite its high success rate, this approach is constrained by substantial side effects. Herbal medicines, known for their diverse bioactive components, exhibit promising anticancer attributes. The drug delivery systems can improve the precision of delivering these herbal compounds, enhancing efficacy while minimizing potential side effects. Various platforms, such as nanoparticle-based carriers, liposomes, and polymeric micelles, are investigated for encapsulating and delivering herbal components to cancer cells. These systems not only enhance the bioavailability of herbal compounds but also facilitate controlled release, sustained drug circulation, and improved cellular uptake. This comprehensive review focuses on the recent advancement in the field of drug delivery systems employed in the delivery of plant-derived anticancer compounds. It categorizes carriers into organic and inorganic nanoparticles, addressing their application in enhancing the safety and efficacy of plant-derived anticancer compounds alongside associated challenges. The review concludes by outlining recent investigations into drug delivery systems aimed at increasing the efficacy of plant-derived anticancer compounds. Future research in this field should emphasize experiments in animal models and potential clinical translation.

Cross-gender hijacking of high achievers by translation students: English to Polish

ABSTRACT In Polish, where different inflectional paradigms apply to female and male names, attributing male gender to female referents such as eminent scientists and authors that pass unnoticed in English becomes visible in scholarly as well as popular scientific texts, exposing the society’s gender bias. While gender bias in machine translation has been widely observed and criticised, it is believed that human translation would eliminate factual mistakes of this type. Yet false attributions of male gender to eminent female linguists found in Polish scholarly texts suggest the contrary. A translation experiment conducted with a group of graduate students of translation was conducted in order to test the presence and strength of the bias, differences between male and female student translators, and the impact of earlier teaching on assigning gender in translation from English to Polish. Both male and female students frequently attributed the male gender to linguistic scholars even in the presence of strong evidence to the contrary, and after prior learning. Male students’ choices were slightly but significantly more biased. The conclusions pertain to the social consequences of the bias and the need to include this topic in translation training while attending more strongly to students’ research and sociocultural competence.

Mitochondrial Control of Proteasomal Psmb5 Drives the Differentiation of Tissue-Resident Memory T Cells in Patients with Rheumatoid Arthritis.

To explore T cell-intrinsic mechanisms underpinning the mal-differentiation of tissue-resident memory T (Trm) cells in patients with rheumatoid arthritis (RA). Circulating T cells from patient with RA and healthy individuals were used for Trm cell differentiation. The role of Hobit in Trm differentiation was investigated through targeted silencing experiments. Psmb5 expression regulation was explored by identifying BRD2 as a key transcription factor, with the interaction validated through chromatin immunoprecipitation-quantitative polymerase chain reaction. The impact of BRD2 succinylation on Trm differentiation was examined by manipulating succinyl-CoA levels in T cells. Humanized NSG chimeras representing synovitis provided insights into Trm infiltration in RA synovitis and were used for translational experiments. In patients with RA, a notable predisposition of CD4+ T cells toward differentiation into Trm cells was observed, demonstrating a positive correlation with the disease activity score 28. Remarkably, Hobit was a pivotal facilitator in the formation of RA CD4+ Trm cells. Mechanistic studies unveiled the dysregulation of proteasomal Psmb5 in T cells of patients with RA as the key factor contributing to elevated Hobit protein levels. The deficiency of proteasomal Psmb5 was intricately linked to BRD2, with succinylation exerting a significant impact on Psmb5 transcription and Trm cell differentiation. This heightened BRD2 succinylation was attributed to elevated levels of mitochondrial succinyl-CoA in RA T cells. Consequently, targeting succinyl-CoA within CD4+ T cells controlled the inflammation of synovial tissues in humanized chimeras. Mitochondrial succinyl-CoA fosters the succinylation of BRD2, resulting in compromised transcription of proteasomal Psmb5 and the differentiation of Trm cells in RA.

An RNA pseudoknot mediates toxin translation and antitoxin inhibition

Type I toxin-antitoxin systems (T1TAs) are bipartite bacterial loci encoding a growth-inhibitory toxin and an antitoxin small RNA (sRNA). In many of these systems, the transcribed toxin mRNA is translationally inactive, but becomes translation-competent upon ribonucleolytic processing. The antitoxin sRNA targets the processed mRNA to inhibit its translation. This two-level control mechanism prevents cotranscriptional translation of the toxin and allows its synthesis only when the antitoxin is absent. Contrary to this, we found that the timP mRNA of the timPR T1TA locus does not undergo enzymatic processing. Instead, the full-length timP transcript is both translationally active and can be targeted by the antitoxin TimR. Thus, tight control in this system relies on a noncanonical mechanism. Based on the results from in vitro binding assays, RNA structure probing, and cell-free translation experiments, we suggest that timP mRNA adopts mutually exclusive structural conformations. The active form uniquely possesses an RNA pseudoknot structure which is essential for translation initiation. TimR preferentially binds to the active conformation, which leads to pseudoknot destabilization and inhibited translation. Based on this, we propose a model in which "structural processing" of timP mRNA enables tight inhibition by TimR in nonpermissive conditions, and TimP synthesis only upon TimR depletion.

Overcoming Communication Barriers in Clinical Care: A Digital Translation Platform.

Language barriers in healthcare can lead to misdiagnosis, inappropriate treatment, and increased medical errors. Efforts to mitigate these include using interpreters and translation tools, but these measures often fall short, particularly when cultural nuances are overlooked. Consequently, medical professionals may have to rely on their staff or patients' relatives for interpretation, compromising the quality of care. This formative pilot study aims to assess the feasibility of Translatly, a digital translation platform, in clinical practice. Specifically, the study focuses on evaluating: 1. how healthcare professionals overcome language barriers and their acceptance of an on-demand video telephony platform, 2. the feasibility of the platform during medical consultations, and 3. identifying potential challenges for future development. The study included ethnographic interviews with healthcare professionals and an observational pilot to assess the use of the Tranlatly platform in clinical practice. Translatly was developed to make real-time translation easy and accessible on both Android and iOS devices. The system's backend architecture uses Java-based services hosted on DigitalOcean. The app securely exchanges data between mobile devices and servers, with user information and call records stored in a MySQL database. An admin panel helps manage the system, and Firebase integration enables fast push notifications to ensure that healthcare professionals can connect with translators whenever they need to. The platform was piloted in a German university hospital with 170 volunteer non-professional translators, mainly medical students, supporting translation in over 20 languages, including Farsi, Dari and Arabic. Ethnographic research conducted by interviewing healthcare professionals in Frankfurt am Main and other German cities revealed that current practices for overcoming language barriers often rely on family members or digital tools like Google Translate, raising concerns about accuracy and emotional distress. Respondents preferred an on-demand translation service staffed by medically experienced translators, such as medical students, who understand medical terminology and can empathize with patients. The observational pilot study recorded 39 requests for translation services, 16 (41%) of which were successfully completed. The translations covered 6 different languages and were carried out by a team of 10 translators. Most requests came from departments such as infectious diseases (5, 31.25%) and emergency (4, 25%). Challenges were identified around translator availability, with 23 (59%) of requests going unanswered, which was further evidenced by user feedback. The pilot study demonstrates the feasibility of the Translatly platform in real-world healthcare settings. It shows potential to improve communication and patient outcomes by addressing language barriers. Despite its potential, challenges such as translator availability highlight the need for further development.

Standardized Protocols for Clinical and Histopathological Characterization of Hidradenitis Suppurativa Tissue Specimens

Methods for describing and reporting the clinical and histological characteristics of cutaneous tissue samples from patients with hidradenitis suppurativa (HS) are not currently standardized, limiting clinicians' and scientists' ability to uniformly record, report, and communicate about the characteristics of tissue used in translational experiments. A recently published consensus statement outlined morphological definitions of typical HS lesions, but no consensus has been reached regarding clinical characterization and examination of HS tissue samples. Here we aimed to establish a protocol for reporting histopathologic and clinical characteristics of HS tissue specimens. This study was conducted from May 2023 to August 2023. Experts in clinical care, dermatopathology, and translational research were recruited, and a modified Delphi technique was used to develop a protocol for histologic reporting and clinical characterization of submitted tissue specimens from HS patients. A total of 27 experts participated (14 dermatologists, 3 fellowship-trained dermatopathologists, 3 plastic surgeons, 3 general surgeons, and 4 research scientists) in creating and reviewing protocols for the clinical and histopathological examination of HS tissue specimens. The protocols were formatted as a synoptic report and will help consistently classify specimens in biobanks based on histological features and more accurately report and select samples used in translational research projects.

SINXRON TАRJIMАDА STRАTEGIYA VА TАKTIKАLАR

The role and characteristics of simultaneous translation (ST) in the general system of translation are very wide, and deeper knowledge and skills are required from simultaneous translator. The translator uses simultaneous interpretation of different types of interpretation, in particular, semantic translation from serial translation and different forms and methods. Translation is also a unique bridge which connects these cultures. Whether it is a written translation or an oral translation, at a certain degree it creates an exchange and acquaintance of cultures. Every language reflects the worldview, psyche and identity of that nation. It gives a heavier task for the translator when performing the translation. Today, simultaneous translation is widely used in meetings of heads of state and international conferences. It is natural that the main topic of such simultaneous translation processes is about politics, the political environment in the neighboring and international arena. In carrying out political translation, an experienced translator always takes into account the hidden ambiguity in the speaker’s speech. This is because in the political context of a country, a word that has a positive meaning often has a negative meaning when it is simultaneously translated into another language. It is no coincidence that "Politics is an art." After all, various political metaphors and euphemisms are often used in politics.

Perceptions of Novice and Experienced Translators toward the Role of High-quality Translated Tourism Promotional Materials (TPMs) in Promoting the Tourism Industry in Saudi Arabia

In today’s world, high-quality translated tourism promotional materials (TPMs) play a leading role in developing business sectors in general and the tourism sector in particular because TPMs are the most often used forms of media targeting actual tourists and other audiences. This study explored the perceptions of novice and experienced translators about the role of high-quality translated TPMs in promoting the tourism industry in Saudi Arabia. Fifty novice and experienced translators in Saudi Arabia participated in this study. Data gathering comprised quantitative data. The findings of the study revealed that a lot of participants (57.00%) had positive perceptions toward the role played by high-quality translated TPMs in promoting the tourism industry in Saudi Arabia. The findings also demonstrated that many of the respondents (60.85%) perceive that the main challenge in the translation of TPMs is culture-specific items that may be comparatively prevalent to the native population but unfamiliar to people outside that certain community.

How external and internal factors affect translators’ source preferences – survey results

ABSTRACT Existing studies on translators’ information-seeking behavior (ISB) have either investigated translators in general or a selected group of translators (e.g. legal translators). The aim of this study was to investigate whether there were differences in the source preferences of translators according to selected factors, such as age, experience, direction of translation, use of CAT tools, post-editing practice, working language, and translation speed. The data were collected through a survey of 226 Polish professional translators. In order to examine the possible differences, we compared the answers of the selected translator subgroups (divided according to the above factors) to one question: ‘On a scale of 1–5, how often do you use the following sources when translating?’ The results were tested for statistical significance. It was found that the authorless online sources were used more often by younger and less experienced translators. MT and CAT technologies do not relieve translators of information research (no drastic differences in the frequency of source use). Translation into the mother tongue generally requires more source consultation than translation into the L2. Translators using technology rely more on non-traditional information sources.

Roundtable Discussion: Translation in Creativity

This Forum, appearing in each issue of the Journal of Literary Multilingualism, aims to continue the conversation started in the very first issue, where we collected articles which assessed and debated the field of literary multilingualism studies. The Forum is a space for shorter, more informal reflections on the field and its future: position papers, dialogues between scholars, roundtable discussions, responses to articles within the journal, and responses to recent multilingualism conferences or events. We welcome proposals for contributions, particularly from marginalized perspectives or on neglected aspects of literary multilingualism. Please contact us directly to discuss ideas. For this Forum, we present a roundtable discussion, organized and moderated by Eugenia Kelbert, in which Vesna Goldsworthy, Matthew Reynolds, and Douglas Robinson share some of their ideas around the relationship between translation and multilingual writing, particularly in relation to their intersecting roles as writers, translators, and academics. — Juliette Batty-Taylor and Till Dembeck, Forum Moderators The study of literary multilingualism exists within the context of recent attempts, by several scholars in comparative literature, to make sense of multilingual and/or global literary practices. From the translation zone (Apter) to born-translated (Walkowitz) or untranslatable fiction, these attempts have almost invariably involved translation, as a concept if not as a practice. What is, then, the place of translation when it comes to understanding multilingual and translingual writing? How does this theoretical debate relate to the actual practice of literary translation? And what happens to literary style when theorists of translation and translators experiment with multilingual writing or when translingual writers translate? The present discussion explores the hitherto undefined zone of creative interaction between translation and multilingual writing in the hope of contributing to the more conceptual debates from a hands-on perspective. It is based on the roundtable entitled “Stylistic Border Crossings in Multilingual and Translated (Con)texts” that was part of the Stylistic Border Crossings In and Beyond Translation conference held on March 9–10, 2023.1 The conference and the roundtable were organized by Eugenia Kelbert with the British Centre for Literary Translation and the East Centre, University of East Anglia. Each of the three guests wears a combination of multiple hats that bridge theory and practice and include “translingual writer,” “literary translator,” “translation studies scholar,” “writer,” and “literary scholar.” — Eugenia Kelbert

Mesenchymal Stem Cell Engagement Modulates Neuroma Microenviroment in Rats and Humans and Prevents Postamputation Pain

Postamputation pain is currently managed unsatisfactorily with neuron-targeted pharmacological and interventional therapies. Non-neuronal pain mechanisms have emerged as crucial factors in the development and persistence of postamputation pain. Consequently, these mechanisms offer exciting prospects as innovative therapeutic targets. We examined the hypothesis that engaging mesenchymal stem cells (MSCs) would foster local neuroimmune interactions, leading to a potential reduction in postamputation pain. We utilized an ex vivo neuroma model from a phantom limb pain patient to uncover that the oligodeoxynucleotide IMT504 engaged human primary MSCs to promote an anti-inflammatory microenvironment. Reverse translation experiments recapitulated these effects. Thus, in an in vivo rat model, IMT504 exhibited strong efficacy in preventing autotomy (self-mutilation) behaviors. This effect was linked to a substantial accumulation of MSCs in the neuroma and associated dorsal root ganglia and the establishment of an anti-inflammatory phenotype in these compartments. Centrally, this intervention reduced glial reactivity in the dorsal horn spinal cord, demonstrating diminished nociceptive activity. Accordingly, the exogenous systemic administration of MSCs phenocopied the behavioral effects of IMT504. Our findings underscore the mechanistic relevance of MSCs and the translational therapeutic potential of IMT504 to engage non-neuronal cells for the prevention of postamputation pain. PerspectiveThe present study suggests that IMT504-dependent recruitment of endogenous MSCs within severely injured nerves may prevent post-amputation pain by modifying the inflammatory scenario at relevant sites in the pain pathway. Reinforcing data in rat and human tissues supports the potential therapeutic value of IMT504 in patients suffering postamputation pain.

Meeting report of the fifth annual workshop on Principles and Techniques for Improving Preclinical to Clinical Translation in Alzheimer's Disease Research.

The fifth annual workshop on Principles and Techniques for Improving Preclinical Translation of Alzheimer's Disease Research was held in May 2023 at The Jackson Laboratory in Bar Harbor, Maine, USA. The workshop was established in 2018 to address training gaps in preclinical translational studies for Alzheimer's disease (AD). In addition to providing fundamental knowledge and hands-on skills essential for executing rigorous in vivo studies that are designed to facilitate translation, each year the workshop aims to provide insight on state-of-the-field technological advances and new resources including novel animal models, publicly available datasets, novel biomarkers, and new medical imaging tracers. This innovative and comprehensive workshop continues to deliver training for the greater AD research community in order to provide investigators and trainees with the knowledge and skillsets essential for enabling improved preclinical to clinical translation and accelerate the process of advancing safe and effective therapeutic interventions for AD. HIGHLIGHTS: Translational research is not typically available as a course of study at academic institutions, yet there are fundamental skillsets and knowledge required to enable successful translation from preclinical experiments to clinical efficacy. It is important that there are resources and opportunities available to researchers planning preclinical translational experiments. Here we present proceedings from the fifth annual NIA-sponsored workshop focused on enabling improved preclinical to clinical translation for Alzheimer's disease research that includes didactic lectures on state-of-the-field approaches and hands-on practicums for acquiring essential translational laboratory techniques.

Gsα Regulates Macrophage Foam Cell Formation During Atherosclerosis.

Many cardiovascular pathologies are induced by signaling through G-protein-coupled receptors via Gsα (G protein stimulatory α subunit) proteins. However, the specific cellular mechanisms that are driven by Gsα and contribute to the development of atherosclerosis remain unclear. High-throughput screening involving data from single-cell and bulk sequencing were used to explore the expression of Gsα in atherosclerosis. The differentially expression and activity of Gsα were analyzed by immunofluorescence and cAMP measurements. Macrophage-specific Gsα knockout (Mac-GsαKO) mice were generated to study the effect on atherosclerosis. The role of Gsα was determined by transplanting bone marrow and performing assays for foam cell formation, Dil-ox-LDL (oxidized low-density lipoprotein) uptake, chromatin immunoprecipitation, and luciferase reporter assays. ScRNA-seq showed elevated Gnas in atherosclerotic mouse aorta's cholesterol metabolism macrophage cluster, while bulk sequencing confirmed increased GNAS expression in human plaque macrophage content. A significant upregulation of Gsα and active Gsα occurred in macrophages from human and mouse plaques. Ox-LDL could translocate Gsα from macrophage lipid rafts in short-term and promote Gnas transcription through ERK1/2 activation and C/EBPβ phosphorylation via oxidative stress in long-term. Atherosclerotic lesions from Mac-GsαKO mice displayed decreased lipid deposition compared with those from control mice. Additionally, Gsα deficiency alleviated lipid uptake and foam cell formation. Mechanistically, Gsα increased the levels of cAMP and transcriptional activity of the cAMP response element binding protein, which resulted in increased expression of CD36 and SR-A1. In the translational experiments, inhibiting Gsα activation with suramin or cpGN13 reduced lipid uptake, foam cell formation, and the progression of atherosclerotic plaques in mice in vivo. Gsα activation is enhanced during atherosclerotic progression and increases lipid uptake and foam cell formation. The genetic or chemical inactivation of Gsα inhibit the development of atherosclerosis in mice, suggesting that drugs targeting Gsα may be useful in the treatment of atherosclerosis.

A target-free vision-based method for out-of-plane vibration measurement using projection speckle and camera self-calibration technology

In recent decades, computer vision-based methods have been introduced into engineering structures to provide full-field, non-contact vibration measurement. However, the vision-based vibration measurement method is challenging to measure the targetless structures. This paper proposed a target-free out-of-plane vibration measurement method using projection speckle and camera self-calibration technology. In this method, the camera extrinsic parameter estimation result based on the direct method is used as the initial value in the proposed method. Then, a nonlinear inequality constraint on the extrinsic parameters is established regarding the epipolar condition to minimize the reprojection error. Furthermore, the projection relationship between the projection speckle displacement and the actual displacement of the structure is studied so that the deviation of the out-of-plane vibration displacement is corrected. In the experimental verification, 3D reconstruction and rigid translation experiments are designed, respectively. The results show that the self-calibration accuracy of the binocular camera proposed in this paper is notably improved compared with the existing methods. At the same time, the deviation correction effect of the vibration displacement is significant. Finally, the typical flat plate structure and composite wing structure are taken as vibration measurement cases to demonstrate that the proposed approach is reliable and accurate in measuring the dynamic responses of engineering structures.

From Text to Action: NLP Techniques for Washing Machine Manual Processing

This scientific research study focuses on the advancements in Natural Language Processing (NLP) driven by large-scale parallel corpora and presents a comprehensive methodology for creating a parallel, multilingual corpus using NLP techniques and semantic technologies, with a particular focus on washing machine manuals. The study highlights the significant progress made in NLP through the utilization of large-scale parallel corpora and advanced NLP techniques. The successful creation of a parallel, multilingual corpus for washing machine manuals, coupled with the integration of semantic technologies and ontology modeling, demonstrates the broad applicability and potential of NLP in diverse domains.The research covers various aspects, including text extraction, segmentation, and the development of specialized pipelines for question-answering, translation, and text summarization tailored for washing machine manuals. Translation experiments using fine-tuned models demonstrated the feasibility of providing washing machine manuals in local languages, expanding accessibility and understanding for users worldwide. Additionally, the study explored text summarization using a powerful transformer-based model, which exhibited remarkable proficiency in generating concise and coherent summaries from complex input texts. The implementation of a question-answering pipeline showcased the effectiveness of various language models in handling question-answering tasks with high accuracy and effectiveness.Additionally, the article discusses the processes of data collection, information preparation, ontology creation, alignment strategies, and text analytics. Furthermore, the study addresses the challenges and potential future developments in this field, offering insights into the promising applications of NLP in the context of washing machine manuals.

The Construction of “Interactive” English Translation Teaching Mode in the Background of Internet

Abstract This paper discusses the construction of “interactive” English translation teaching mode in the background of the Internet, and analyzes the application of neural machine translation model in improving the effect of translation teaching. The research adopts Word2vec algorithm to train word vectors, combines neural network language model and encoder-decoder structure, and constructs Transformer model and CNN+Transformer model to improve translation efficiency and quality. The translation experiments on sentences of different lengths show that the models perform better in short sentence translation. The experimental results show that the proposed model outperforms the traditional model in terms of BLEU value, and the best translation effect is found in test set 1, where the BLEU value is improved by 10.6 and 11.7 compared with that of the baseline model and the CNN model, respectively. The “interactive” teaching mode designed with POA theory significantly outperforms the traditional teaching mode regarding students’ lexical, grammatical and semantic translation quality. The “interactive” English translation teaching with neural translation model can effectively improve the quality of translation teaching and students’ learning effect.