Comparative Effectiveness Research Translation Research Articles

Impact of comparative effectiveness research on Medicare coverage of direct oral anticoagulants.

Aim: To evaluate the association of comparative effectiveness research with Medicare coverage of direct oral anticoagulants. Materials & methods: A literature review for direct oral anticoagulants was conducted from 2011 to 2017. Monthly prescription drugplan and formularyfiles (n =28) were used to conduct change-point analysis and assess each outcome variable. Results: Up to 2013, studies showed that dabigatran was more effective than rivaroxaban. In 2015, apixaban was shown to be the safest and most effective drug in comparison with all direct oral anticoagulants. In 2016-2017, dabigatran and apixaban were shown to have similar efficacy. Approximately 75% of plans covered dabigatran under tier 3until 2015. From 2011 to 2017, less than 30% of plans required prior authorizations, 50% imposed quantity limits and mean copayment was lowest for rivaroxaban. Conclusion: Consistent with comparative effectiveness research, Medicare plans covered apixaban more favorably and edoxaban less favorably. However, discrepancies in comparative effectiveness research translation were found for rivaroxaban and dabigatran.

Understanding Source-Related Influences on Physicians’ Translating Comparative Effectiveness Research into Patient Care: Results from a Study of Cardiologists

Comparative effectiveness research (CER), which refers to an evaluation of the clinical effectiveness of two or more medical interventions that are used to treat the same condition, has the potential to inform decision-making in both policy circles and physicians’ exam rooms. The ability of stakeholders to translate that research into practice has important implications for health outcomes, but the impact of information sources on physicians in translating CER remains understudied. This project examines the source-related influences on and motivations of cardiologists with respect to willingness to make changes in their practice based on emerging CER results. The results from this survey of cardiologists (N = 42) indicate that the source of information (including perceived credibility of those sources) matters greatly to cardiologists when deciding whether to make a change in practice. These findings suggest data-based implications for researchers and practitioners that are engaged in closing the CER translation gap.

Increasing adoption of comparative effectiveness research in community behavioral health: methodology.

Increased efforts in comparative effectiveness research (CER) (comparing various health care intervention and treatment options) are being used to inform health care delivery. While CER research itself is an important step in developing best practices in health care, it is not enough to ensure success. The knowledge must also be successfully disseminated to increase adoption and implementation of practices. To ensure the greatest benefits of successful interventions, it is essential to understand which dissemination strategies are effective and under what conditions. This article provides the background and methodology used in a large-scale, 2-year study aimed at determining how knowledge gained from CER research may be most effectively disseminated to those responsible for delivering behavioral health services. The study takes an important step toward addressing the gaps in dissemination and translation of CER.