Batch or semi-batch chemical reaction units often requires multiple operational phases to convert reactants to valuable products. In various chemical production facilities, the switching decision of such operational phases has to be confirmed and registered by the operating personnel. Imprecise switching of phases can waste a significant amount of time and energy for the reaction unit, which gives negative plant sustainability and costs. Additionally, automation for phase switching is rarely used due to the challenges of batch-to-batch variance, sensor instability, and various process uncertainties. Here, we demonstrate that by using a machine learning approach which includes optimized noise removal methods and a neural network (that was neural architecture searched), the real-time reaction completion could be precisely tracked (R2 > 0.98). Furthermore, we show that the latent space of the evolved neural network could be transferred from predicting reaction completion to classifying the reaction operational phase via optimal transfer learning. From the optimally transfer learned network, a novel phase switch index is proposed to act as a digital phase switch and is shown to be capable of reducing total reactor operation time, with the verification of an operator. These intelligent analytics was studied on a reactive distillation unit for a reaction of monomers and acids to polyester in the Netherlands. The combined analytics gave a potential of 5.4% reaction batch time saving, 10.6% reaction energy savings, and 10.5% carbon emissions reduction. For the operator, this method also saves up to 6 h during the end discharge of the reaction.