The failure mechanism and structural behavior of transfer beams supporting in-plane loaded shear walls have received added emphasis owing to their importance in connection with tall building construction. This paper presents an analysis of and investigation of the structural behavior of two-span transfer beam-shear wall systems in tall buildings. The interaction between the transfer girders and the shear wall has been investigated considering interior and exterior column interaction effects. The upper structural form has a significant effect on the failure mechanism of the transfer girders, which can act as full tension members or behave as ordinary flexural beams. Stress distributions in the shear wall interactive zone are presented. The relevant parameters that significantly influence the force transfer mechanism and structural behavior, such as the span/depth ratio of the transfer beam, the span of the shear wall and the stiffness of the support columns, are highlighted. The present paper provides a very useful reference for the design of continuous transfer girders supporting in-plane loaded shear walls in tall buildings.