Rosuvastatin calcium is a low solubility containing anti-lipidemic drug and provides only 20% of oral bioavailability. Following a different route of administration can overcome the first pass metabolism and may improve the bioavailability. Therefore the present study aimed to design and characterize a transdermal patch containing rosuvastatn calcium nanospoges (RST-NSP) to enhance the drug dissolution. Emulsion solvent diffusion method was used in the preparation of (RST-NSP) employing β-cyclodextrin and poly vinyl alcohol as solubility enhancers. Design Expert® 13 was employed to design twenty formulations in which concentration of β-Cyclodextrin in mg (A), ethylcellulose in mg (B) and reaction time in hrs (C) were taken as independent factors, where as entrapment efficiency (%) and particle size were considered two responses. Triple fold increase in solubility, 86 % of entrapment efficiency, 200 nm particle size containing NSP were loaded in transdermal patch by solvent casting method, with hydroxypropyl methyl cellulose and cabopol as polymers in 3:1 ratio. SEM analysis showed the uniform distribution of nanosponges and its morphology. The transdermal patch loaded NSP released the drug up to 10 h. Kinetic modeling on release data showed that the best fitted model was Higuchi model and release mechanism was by Fickian diffusion.