The Sierra Nevada de Santa Marta (Santa Marta) in Colombia and Nevado del Famatina (Famatina) in Argentina are two isolated peaks within the Andes of South America, having elevations of about 5,500 and 6,000 m, respectively. Both massifs are bounded by major wrench faults of opposite kinematics but comparable magnitude in their lateral displacement. Despite the volumes of research available, little has been said in the literature about the tectonics surrounding these particular systems. In this context, digital terrain elevation (DEM), regional geology, satellite imagery and geophysical data were analysed to illustrate how a network of transcurrent faults uplifted the peaks. We propose a model to account for topography by the opposed movement of faults operating in two compartments: internal (acute) and external (obtuse). Fault motion caused uplift of the internal compartments: a) the Santa Marta tectonic syntaxis is generated by the sinistral Santa Marta-Bucaramanga Fault on the west and the dextral Oca-Pilar Fault to the north whilst, b) the Famatina tectonic syntaxis is caused by the Valle Fértil sinistral fault on the western side and the dextral Tucumán lineament to the north. Elevation maps documenting the lateral displacement of modern alluvial fans provide evidence of the existence and kinematics of these faults. Active since the Neogene, the transcurrent faults resulted in displacements in the order of 25–60 km, with velocities of approximately 1–2 cm/year. Seismic records suggest that the syntaxis occurred after reactivation of oblique discontinuities in the basement due to the convergence of the Nazca, Caribbean, and South American plates. This tectonic framework led to the formation of a remarkable positive relief and the development of internal positive compartments subject to constrictive forces. Simultaneously, external distensive and negative compartments controlled the syntectonic deposition of thick sedimentary sequences. The significant topographic difference between the internal positive compartments and their external negative counterparts triggered high rates of erosion, transport, and ultimately sedimentation. Regional subsurface surveys indicate strong anomalies of the underlying bedrock influenced by tectonic syntaxis.