Aim. The problems of cooperation between the Russian Federation and the Republic of Kazakhstan in the field of nature management and environmental safety are considered. Possible directions for the development of cooperation both at the interstate and interregional levels of border territories are presented. Purpose is to analyse the current state of cooperation between the Russian Federation and the Republic of Kazakhstan in the field of environmental management and environmental safety. Material and Methods. The main results were obtained using a systematic approach through field geographical research, comparative historical and comparative typological analysis, etc. Materials regarding water resources, reservoirs and statistical indicators of the dynamics and structure of water use were used. Results. The main problems in the field of nature management and environmental safety of the two countries were identified. The prospects of interstate cooperation between Russia and Kazakhstan at the interstate and regional levels on transboundary environmental problems and sustainable use of land and water resources, protection of wildlife are identified and substantiated. Based on a retrospective analysis of the experience of interaction between the two countries and possible prospects for cooperation, concepts and directions for the development of strategic partnership in field of cross‐border nature management and environmental safety of transboundary water bodies, and the conservation of migratory species of wildlife are proposed. Conclusions. The modern post–virgin space is confidently transforming into an agro‐export one – an analogue of the virgin one at a new technological and climatic stage with an export orientation in the face of new challenges. The further development of this space should be based on the optimisation of agriculture and water use, taking into account the preservation of natural diversity.