The article deals with the European aspects of the US foreign policy in the 2nd half of the 20th century. It also includes studies of the transatlantic relations of the described period and the exploration of an American influence on European integration processes. It is determined that the United States has demonstrated itself as a partner of the Western governments in the post-war reconstruction and further creation of an area of US security and prosperity. At the same time, it is noted that the American presidents have differently shaped their administrations’ policies towards Europe. The greatest supporter of the European integration processes was President Eisenhower. Among other things, the US President believed that Europe would become a key ally of the United States, thus, he considered the union of Sweden, Greece, Spain and Yugoslavia as a solid foundation for building a “United States of Europe”. After Eisenhower administration, European affairs, to a lesser extent, were taken up by such Presidents as Johnson, Carter, Reagan and Clinton. Showing no personal interest, Kennedy, Nixon and Bush-Sr. were forced to support the transatlantic dialogue, understanding the inevitability of European integration and the need for the United States to cooperate with the new consolidated actor. The United States aimed to strengthen its position in the European space, moving to that purpose by using NATO mechanisms and applying the policies of American protectionism against the communist threat. The main competitor of the United States for strengthening national positions in Europe was France led by General de Gaulle, who believed that the affairs of Europe should be resolved by European governments without the American intervention. However, NATO continued to serve as a springboard for the U.S. involvement in European affairs. At the end of the 20th century, through the close links between the EU and NATO, the USA received new allies from Central and Eastern European countries. It is concluded that after the end of World War II, Europe needed an assistance that the United States willingly provided in exchange for the ability to participate in European issues, solving and partly controlling the integration processes. The study found that, despite the varying degree of the American interest in transatlantic affairs, Europe has consistently been remaining a zone of national interest for the United States.